fibromyalgia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. (Experimental Factor Ontology, EFO_0005687)
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Genes

205 genes co-occuring with the disease fibromyalgia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.79751
TAC1 tachykinin, precursor 1 1.67457
SIK1 salt-inducible kinase 1 1.36379
COMT catechol-O-methyltransferase 1.31624
NPS neuropeptide S 1.23299
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.21348
IGF1 insulin-like growth factor 1 (somatomedin C) 1.21262
TSKU tsukushi, small leucine rich proteoglycan 1.20959
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.16264
POMC proopiomelanocortin 1.12445
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 1.06774
CRH corticotropin releasing hormone 1.06732
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.977165
CIDEC cell death-inducing DFFA-like effector c 0.948269
NCAM1 neural cell adhesion molecule 1 0.93497
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.915963
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.862228
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.849126
MRPL49 mitochondrial ribosomal protein L49 0.843802
CYHR1 cysteine/histidine-rich 1 0.807718
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.805257
CRP C-reactive protein, pentraxin-related 0.752898
CD68 CD68 molecule 0.745578
PRF1 perforin 1 (pore forming protein) 0.741517
NPY neuropeptide Y 0.730976
TACR1 tachykinin receptor 1 0.686291
FLT3LG fms-related tyrosine kinase 3 ligand 0.678302
VASN vasorin 0.678302
TSC22D3 TSC22 domain family, member 3 0.677504
OPRM1 opioid receptor, mu 1 0.667947
LEP leptin 0.664372
BDNF brain-derived neurotrophic factor 0.661197
IFNB1 interferon, beta 1, fibroblast 0.658818
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.65565
PNLIP pancreatic lipase 0.640251
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.634742
CALCA calcitonin-related polypeptide alpha 0.630813
CD4 CD4 molecule 0.6214
IL1B interleukin 1, beta 0.6214
NGF nerve growth factor (beta polypeptide) 0.621008
EDC3 enhancer of mRNA decapping 3 0.617094
FMR1 fragile X mental retardation 1 0.612011
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.607714
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.60069
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.589779
IL6 interleukin 6 0.588222
MGAM maltase-glucoamylase 0.587444
PTRF polymerase I and transcript release factor 0.583941
PLIN1 perilipin 1 0.561392
IL2 interleukin 2 0.560616
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.559062
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.558674
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.548583
MYT1L myelin transcription factor 1-like 0.53928
SST somatostatin 0.538893
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.535022
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.530768
CCL16 chemokine (C-C motif) ligand 16 0.522659
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.520731
ELP2 elongator acetyltransferase complex subunit 2 0.51919
PRSS21 protease, serine, 21 (testisin) 0.518034
GATA2 GATA binding protein 2 0.495793
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.493122
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.48893
PGAM1 phosphoglycerate mutase 1 (brain) 0.484364
TNF tumor necrosis factor 0.482084
MAOA monoamine oxidase A 0.470332
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.469954
CD79A CD79a molecule, immunoglobulin-associated alpha 0.468819
INS insulin 0.467306
PTH parathyroid hormone 0.463527
ORM2 orosomucoid 2 0.463149
MYDGF myeloid-derived growth factor 0.461639
TK2 thymidine kinase 2, mitochondrial 0.460129
ASIC3 acid sensing (proton gated) ion channel 3 0.457487
TAAR1 trace amine associated receptor 1 0.453716
GCH1 GTP cyclohydrolase 1 0.442795
GHRH growth hormone releasing hormone 0.441666
CROCC ciliary rootlet coiled-coil, rootletin 0.439786
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.435651
LYZ lysozyme 0.428891
IL1RN interleukin 1 receptor antagonist 0.419892
PREP prolyl endopeptidase 0.419517
SPAG1 sperm associated antigen 1 0.419142
NAV1 neuron navigator 1 0.418768
C11ORF40 chromosome 11 open reading frame 40 0.416147
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.411657
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.404931
RTN1 reticulon 1 0.402318
CD7 CD7 molecule 0.401572
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.396725
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.393374
CD5 CD5 molecule 0.393001
GHRL ghrelin/obestatin prepropeptide 0.391885
TPH1 tryptophan hydroxylase 1 0.386308
FICD FIC domain containing 0.378143
PEPD peptidase D 0.368888
NRXN3 neurexin 3 0.360395
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.358551
ZMPSTE24 zinc metallopeptidase STE24 0.356709
CS citrate synthase 0.35082
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.349349
PNOC prepronociceptin 0.347511
TRH thyrotropin-releasing hormone 0.346777
ALPPL2 alkaline phosphatase, placental-like 2 0.344574
ALPP alkaline phosphatase, placental 0.344207
ALPL alkaline phosphatase, liver/bone/kidney 0.34384
GPR135 G protein-coupled receptor 135 0.343473
RECQL5 RecQ protein-like 5 0.340906
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.339073
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.335412
TKT transketolase 0.331391
ICK intestinal cell (MAK-like) kinase 0.328469
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.316456
TOLLIP toll interacting protein 0.313552
AMT aminomethyltransferase 0.312827
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.305587
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.304864
SNAP25 synaptosomal-associated protein, 25kDa 0.304503
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.302698
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.299812
IGFBP3 insulin-like growth factor binding protein 3 0.299452
CXCL8 chemokine (C-X-C motif) ligand 8 0.290821
GBP1 guanylate binding protein 1, interferon-inducible 0.287952
PRL prolactin 0.277227
ELANE elastase, neutrophil expressed 0.27153
IL2RA interleukin 2 receptor, alpha 0.270819
LIPC lipase, hepatic 0.269516
DRD4 dopamine receptor D4 0.267977
IGLV5-52 immunoglobulin lambda variable 5-52 0.266203
KAT8 K(lysine) acetyltransferase 8 0.26514
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.263368
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.261952
FBXW2 F-box and WD repeat domain containing 2 0.260891
TRIM25 tripartite motif containing 25 0.257005
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.255594
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.253831
POLB polymerase (DNA directed), beta 0.253831
STX11 syntaxin 11 0.252422
AADACL3 arylacetamide deacetylase-like 3 0.251015
POMP proteasome maturation protein 0.247501
CAT catalase 0.245396
PRKG1 protein kinase, cGMP-dependent, type I 0.243295
MEFV Mediterranean fever 0.233183
HECA headcase homolog (Drosophila) 0.232142
CCL2 chemokine (C-C motif) ligand 2 0.230755
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.228679
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.228333
PRRC2A proline-rich coiled-coil 2A 0.226607
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.222822
PRKCA protein kinase C, alpha 0.219057
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.211597
HOPX HOP homeobox 0.210253
LSP1 lymphocyte-specific protein 1 0.208579
MED28 mediator complex subunit 28 0.207912
WDFY2 WD repeat and FYVE domain containing 2 0.205254
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.204263
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.20229
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.196139
BPGM 2,3-bisphosphoglycerate mutase 0.194865
PGAM2 phosphoglycerate mutase 2 (muscle) 0.192657
SCG2 secretogranin II 0.190476
ICAM1 intercellular adhesion molecule 1 0.190476
MRS2 MRS2 magnesium transporter 0.187113
TRIM21 tripartite motif containing 21 0.185612
VPREB1 pre-B lymphocyte 1 0.180937
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.180652
SCN10A sodium channel, voltage gated, type X alpha subunit 0.178126
TALDO1 transaldolase 1 0.173057
RBMS1 RNA binding motif, single stranded interacting protein 1 0.171535
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.170789
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.165655
S100A8 S100 calcium binding protein A8 0.165217
GPX1 glutathione peroxidase 1 0.163523
RETN resistin 0.163111
APLP1 amyloid beta (A4) precursor-like protein 1 0.162505
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.161331
GAL galanin/GMAP prepropeptide 0.159838
AMPD1 adenosine monophosphate deaminase 1 0.158778
CFP complement factor properdin 0.145022
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.143155
IRS1 insulin receptor substrate 1 0.142175
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.141962
MX1 MX dynamin-like GTPase 1 0.141899
PLAUR plasminogen activator, urokinase receptor 0.141828
TARP TCR gamma alternate reading frame protein 0.141742
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 0.141716
DYNLT1 dynein, light chain, Tctex-type 1 0.141481
LPL lipoprotein lipase 0.14141
S100A9 S100 calcium binding protein A9 0.14121
ALK anaplastic lymphoma receptor tyrosine kinase 0.140601
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.140148
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.139934
CD2 CD2 molecule 0.139915
BANF1 barrier to autointegration factor 1 0.139577
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.139492
FRZB frizzled-related protein 0.139339
CAV1 caveolin 1, caveolae protein, 22kDa 0.138737
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.138564
ASRGL1 asparaginase like 1 0.13845
INSR insulin receptor 0.138136
LMNA lamin A/C 0.137933
SUMF2 sulfatase modifying factor 2 0.135605
C1S complement component 1, s subcomponent 0.134874
FOXL2 forkhead box L2 0.134729