filopodium Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. (Gene Ontology, GO_0030175)
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Genes

334 proteins co-occuring with the filopodium cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDC42 cell division cycle 42 2.35448
FSCN1 fascin actin-bundling protein 1 1.74701
MYO10 myosin X 1.74193
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.69706
BAIAP2 BAI1-associated protein 2 1.69706
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 1.69522
VASP vasodilator-stimulated phosphoprotein 1.64793
FSCN3 fascin actin-bundling protein 3, testicular 1.60651
FSCN2 fascin actin-bundling protein 2, retinal 1.60069
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.36747
DIAPH3 diaphanous-related formin 3 1.36692
FMN1 formin 1 1.19777
WAS Wiskott-Aldrich syndrome 1.19006
MSN moesin 1.18286
EZR ezrin 1.14597
FN1 fibronectin 1 1.09594
VCL vinculin 1.08069
RHOF ras homolog family member F (in filopodia) 1.07714
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.06044
RDX radixin 1.05842
MYO3A myosin IIIA 1.05488
ICAM5 intercellular adhesion molecule 5, telencephalin 1.03479
DBN1 drebrin 1 1.01536
EPS8 epidermal growth factor receptor pathway substrate 8 0.974198
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.95305
NTN1 netrin 1 0.944007
PXN paxillin 0.933129
NGF nerve growth factor (beta polypeptide) 0.907855
DLL4 delta-like 4 (Drosophila) 0.89672
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.85388
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene) 0.85388
WASL Wiskott-Aldrich syndrome-like 0.846532
LY6G5C lymphocyte antigen 6 complex, locus G5C 0.832761
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.829548
CTTN cortactin 0.799728
PLXND1 plexin D1 0.797895
GPM6A glycoprotein M6A 0.794229
VEGFA vascular endothelial growth factor A 0.793313
MCF2 MCF.2 cell line derived transforming sequence 0.788733
NEXN nexilin (F actin binding protein) 0.775014
PALM paralemmin 0.774101
FRMD1 FERM domain containing 1 0.769083
FMNL3 formin-like 3 0.762707
PKN1 protein kinase N1 0.746833
NCKIPSD NCK interacting protein with SH3 domain 0.742769
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.698223
BDNF brain-derived neurotrophic factor 0.697344
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.69164
PLEK pleckstrin 0.68508
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.683771
PFN1 profilin 1 0.682899
PFN2 profilin 2 0.668559
BAIAP2L1 BAI1-associated protein 2-like 1 0.657757
PALM3 paralemmin 3 0.64915
PALM2 paralemmin 2 0.64915
PALM2-AKAP2 PALM2-AKAP2 readthrough 0.64915
WIPF3 WAS/WASL interacting protein family, member 3 0.648291
PFN4 profilin family, member 4 0.647003
GSN gelsolin 0.643144
FGD3 FYVE, RhoGEF and PH domain containing 3 0.632451
VAV2 vav 2 guanine nucleotide exchange factor 0.632451
CLEC14A C-type lectin domain family 14, member A 0.629039
CD44 CD44 molecule (Indian blood group) 0.624355
ARHGAP1 Rho GTPase activating protein 1 0.61968
MYO3B myosin IIIB 0.617133
SDC3 syndecan 3 0.613318
RHOBTB1 Rho-related BTB domain containing 1 0.612895
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.603596
SDC2 syndecan 2 0.601909
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.596435
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.587199
ACTB actin, beta 0.584686
FAM21C family with sequence similarity 21, member C 0.578416
ZYX zyxin 0.577581
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.569664
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.568416
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.567169
ESPN espin 0.564262
PRRX2 paired related homeobox 2 0.563432
TENM2 teneurin transmembrane protein 2 0.563017
ACTG1 actin gamma 1 0.558457
FMNL1 formin-like 1 0.554732
NF2 neurofibromin 2 (merlin) 0.54936
EFNB2 ephrin-B2 0.545236
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.543587
GAS7 growth arrest-specific 7 0.535772
RHOQ ras homolog family member Q 0.535361
RHOU ras homolog family member U 0.534951
WWC2 WW and C2 domain containing 2 0.531668
CD302 CD302 molecule 0.528388
ESM1 endothelial cell-specific molecule 1 0.527569
VAV3 vav 3 guanine nucleotide exchange factor 0.522659
WASF3 WAS protein family, member 3 0.521023
SCN4B sodium channel, voltage gated, type IV beta subunit 0.514493
TIAM1 T-cell lymphoma invasion and metastasis 1 0.505944
MAP1B microtubule-associated protein 1B 0.501881
MYLK myosin light chain kinase 0.50107
IQGAP1 IQ motif containing GTPase activating protein 1 0.482064
FAM110C family with sequence similarity 110, member C 0.480453
MYH10 myosin, heavy chain 10, non-muscle 0.479647
THSD7A thrombospondin, type I, domain containing 7A 0.476027
FYN FYN proto-oncogene, Src family tyrosine kinase 0.468401
ARHGAP31 Rho GTPase activating protein 31 0.466399
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.464397
DIAPH2 diaphanous-related formin 2 0.460401
INSR insulin receptor 0.456012
F2R coagulation factor II (thrombin) receptor 0.455214
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.454816
ARF6 ADP-ribosylation factor 6 0.454418
CRMP1 collapsin response mediator protein 1 0.454418
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.452825
SYNE2 spectrin repeat containing, nuclear envelope 2 0.452029
FGD1 FYVE, RhoGEF and PH domain containing 1 0.444482
LIN7A lin-7 homolog A (C. elegans) 0.441708
NCAM1 neural cell adhesion molecule 1 0.438146
WASF1 WAS protein family, member 1 0.433407
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.432224
ABI1 abl-interactor 1 0.431435
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.428678
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.427891
SYK spleen tyrosine kinase 0.420036
KNG1 kininogen 1 0.418077
CSF1 colony stimulating factor 1 (macrophage) 0.416511
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.412992
AKAP12 A kinase (PRKA) anchor protein 12 0.402859
VAV1 vav 1 guanine nucleotide exchange factor 0.402081
NOTCH1 notch 1 0.401304
MARCKS myristoylated alanine-rich protein kinase C substrate 0.401304
RAB17 RAB17, member RAS oncogene family 0.399363
MYO15A myosin XVA 0.399363
MYO1A myosin IA 0.393549
LIMK1 LIM domain kinase 1 0.392775
ADAP1 ArfGAP with dual PH domains 1 0.390068
CDH5 cadherin 5, type 2 (vascular endothelium) 0.389682
KIRREL2 kin of IRRE like 2 (Drosophila) 0.386979
EPB41 erythrocyte membrane protein band 4.1 0.386593
CXCL12 chemokine (C-X-C motif) ligand 12 0.386593
RALGDS ral guanine nucleotide dissociation stimulator 0.385822
LIMK2 LIM domain kinase 2 0.385436
SH2D3A SH2 domain containing 3A 0.379276
RND1 Rho family GTPase 1 0.379276
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.377354
CDCP1 CUB domain containing protein 1 0.376586
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.375818
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.374283
SEBOX SEBOX homeobox 0.369684
ARHGAP33 Rho GTPase activating protein 33 0.368536
FLT4 fms-related tyrosine kinase 4 0.366623
GAP43 growth associated protein 43 0.363185
MMP9 matrix metallopeptidase 9 0.362804
HAS3 hyaluronan synthase 3 0.362422
WIPF2 WAS/WASL interacting protein family, member 2 0.357467
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.356324
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.356324
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.355944
BVES blood vessel epicardial substance 0.354422
TENM1 teneurin transmembrane protein 1 0.354422
OLIG3 oligodendrocyte transcription factor 3 0.353282
OPHN1 oligophrenin 1 0.352522
RAP1GAP RAP1 GTPase activating protein 0.351762
STMN2 stathmin 2 0.34645
DCC DCC netrin 1 receptor 0.345314
AMPH amphiphysin 0.342664
VANGL2 VANGL planar cell polarity protein 2 0.338128
EGFR epidermal growth factor receptor 0.337373
CD47 CD47 molecule 0.336996
MYO5A myosin VA (heavy chain 12, myoxin) 0.332848
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.332472
FZD3 frizzled class receptor 3 0.332095
PALMD palmdelphin 0.329461
TNNT1 troponin T type 1 (skeletal, slow) 0.327956
IQGAP2 IQ motif containing GTPase activating protein 2 0.324951
NDP Norrie disease (pseudoglioma) 0.324576
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.318953
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.311105
TTYH1 tweety family member 1 0.310358
NOTUM notum pectinacetylesterase homolog (Drosophila) 0.30924
MYL9 myosin, light chain 9, regulatory 0.306632
AMOT angiomotin 0.304399
TJP1 tight junction protein 1 0.303655
WASH7P WAS protein family homolog 7 pseudogene 0.30254
SMPX small muscle protein, X-linked 0.301054
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.299569
WASH6P WAS protein family homolog 6 pseudogene 0.299197
SYN1 synapsin I 0.298084
TSPAN12 tetraspanin 12 0.296972
WASH1 WAS protein family homolog 1 0.296601
RRAS related RAS viral (r-ras) oncogene homolog 0.295119
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.294748
CD9 CD9 molecule 0.294378
EMCN endomucin 0.292157
EFNB3 ephrin-B3 0.291417
PARM1 prostate androgen-regulated mucin-like protein 1 0.289569
CD151 CD151 molecule (Raph blood group) 0.288829
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 0.286983
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.286983
FKBP15 FK506 binding protein 15, 133kDa 0.286614
FGF2 fibroblast growth factor 2 (basic) 0.284769
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.282926
MOB1B MOB kinase activator 1B 0.281453
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.280349
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.277406
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.276304
EFS embryonal Fyn-associated substrate 0.273
FAM65B family with sequence similarity 65, member B 0.2719
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.271533
PFN3 profilin 3 0.270434
DOCK1 dedicator of cytokinesis 1 0.269701
DPYSL3 dihydropyrimidinase-like 3 0.268237
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.268237
GPM6B glycoprotein M6B 0.267139
EPHA8 EPH receptor A8 0.266774
DNM2 dynamin 2 0.266774
NRP1 neuropilin 1 0.264946
DAAM1 dishevelled associated activator of morphogenesis 1 0.263485
CDC42SE1 CDC42 small effector 1 0.26312
RHOJ ras homolog family member J 0.257289
DAAM2 dishevelled associated activator of morphogenesis 2 0.254017
FAT3 FAT atypical cadherin 3 0.252202
PLS1 plastin 1 0.252202
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.249664
FMN2 formin 2 0.248578
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.247854
ARHGAP18 Rho GTPase activating protein 18 0.247492
PARD6A par-6 family cell polarity regulator alpha 0.247492
EXOC7 exocyst complex component 7 0.24713
STARD13 StAR-related lipid transfer (START) domain containing 13 0.245685
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.244962
DIAPH1 diaphanous-related formin 1 0.244962
AQP9 aquaporin 9 0.242076
CLASP1 cytoplasmic linker associated protein 1 0.242076
SH2B1 SH2B adaptor protein 1 0.240636
NGDN neuroguidin, EIF4E binding protein 0.239916
LHX8 LIM homeobox 8 0.239557
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 0.239197
PSD pleckstrin and Sec7 domain containing 0.235966
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.235249
RHOB ras homolog family member B 0.234174
CDON cell adhesion associated, oncogene regulated 0.233459
MAP1S microtubule-associated protein 1S 0.232029
NCK2 NCK adaptor protein 2 0.230958
EPHB2 EPH receptor B2 0.228464
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.228108
ASTN1 astrotactin 1 0.227752
FZD1 frizzled class receptor 1 0.227397
PLS3 plastin 3 0.227041
PTCH1 patched 1 0.226331
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.225267
TMOD4 tropomodulin 4 (muscle) 0.224913
EVL Enah/Vasp-like 0.224558
PLAU plasminogen activator, urokinase 0.224204
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.22173
NEBL nebulette 0.221025
ESAM endothelial cell adhesion molecule 0.219969
FGFR1 fibroblast growth factor receptor 1 0.217861
CDC42SE2 CDC42 small effector 2 0.217511
TPM1 tropomyosin 1 (alpha) 0.21716
FLNA filamin A, alpha 0.215761
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.214017
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.209858
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.208481
SARM1 sterile alpha and TIR motif containing 1 0.208137
SYP synaptophysin 0.207794
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.206082
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.204039
NCK1 NCK adaptor protein 1 0.201335
SPAST spastin 0.200999
FLT1 fms-related tyrosine kinase 1 0.200328
MOB1A MOB kinase activator 1A 0.199659
HLX H2.0-like homeobox 0.199325
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.198991
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.197662
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.197662
SCN3A sodium channel, voltage gated, type III alpha subunit 0.195025
TENM4 teneurin transmembrane protein 4 0.194698
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.194045
ALPPL2 alkaline phosphatase, placental-like 2 0.193719
SDCBP syndecan binding protein (syntenin) 0.193394
SEPT6 septin 6 0.193394
ALPL alkaline phosphatase, liver/bone/kidney 0.19307
ARHGAP35 Rho GTPase activating protein 35 0.19307
GRB7 growth factor receptor-bound protein 7 0.192746
ALPP alkaline phosphatase, placental 0.192746
SGSM3 small G protein signaling modulator 3 0.190814
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.189222
GFRA2 GDNF family receptor alpha 2 0.18859
BOC BOC cell adhesion associated, oncogene regulated 0.188274
NET1 neuroepithelial cell transforming 1 0.18796
VWF von Willebrand factor 0.187333
NTS neurotensin 0.185469
FMNL2 formin-like 2 0.184853
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.184241
SIRPA signal-regulatory protein alpha 0.183935
TUBA1A tubulin, alpha 1a 0.183025
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.182422
ACPP acid phosphatase, prostate 0.181524
HOXA4 homeobox A4 0.18093
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.18093
ACTA1 actin, alpha 1, skeletal muscle 0.178877
AQR aquarius intron-binding spliceosomal factor 0.178299
NOSTRIN nitric oxide synthase trafficking 0.178011
TGFB3 transforming growth factor, beta 3 0.17687
NEO1 neogenin 1 0.176305
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.176024
SORT1 sortilin 1 0.176024
FAT2 FAT atypical cadherin 2 0.175745
TIAM2 T-cell lymphoma invasion and metastasis 2 0.172468
FAT4 FAT atypical cadherin 4 0.171673
CD81 CD81 molecule 0.169604
PDCL3 phosducin-like 3 0.16935
MMP2 matrix metallopeptidase 2 0.168349
PUM2 pumilio RNA-binding family member 2 0.168101
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.167856
EFNA1 ephrin-A1 0.167366
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.166643
DOCK7 dedicator of cytokinesis 7 0.166643
MET MET proto-oncogene, receptor tyrosine kinase 0.165463
RAB5A RAB5A, member RAS oncogene family 0.165463
TWF2 twinfilin actin binding protein 2 0.165
FAT1 FAT atypical cadherin 1 0.16477
CNTN2 contactin 2 (axonal) 0.164542
DLL3 delta-like 3 (Drosophila) 0.163641
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.16342
ARHGAP6 Rho GTPase activating protein 6 0.1632
CDV3 CDV3 homolog (mouse) 0.16298
RTN4 reticulon 4 0.162763
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.16233
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.161693
NLGN1 neuroligin 1 0.160053
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.159268
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.158129
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.15776
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.15776
SHH sonic hedgehog 0.157397