finasteride-3641 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the finasteride-3641 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMPD1 adenosine monophosphate deaminase 1
ANGPT4 angiopoietin 4
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP10B ATPase, class V, type 10B
BIN1 bridging integrator 1
C3 complement component 3
CA4 carbonic anhydrase IV
CA9 carbonic anhydrase IX
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD5 CD5 molecule
CDON cell adhesion associated, oncogene regulated
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
COL4A2 collagen, type IV, alpha 2
CTSO cathepsin O
CYLD cylindromatosis (turban tumor syndrome)
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DNASE1 deoxyribonuclease I
ELOVL2 ELOVL fatty acid elongase 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GJA8 gap junction protein, alpha 8, 50kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
HIF3A hypoxia inducible factor 3, alpha subunit
HR hair growth associated
HRASLS HRAS-like suppressor
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL1RN interleukin 1 receptor antagonist
ING2 inhibitor of growth family, member 2
IRF4 interferon regulatory factor 4
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLHL29 kelch-like family member 29
KMT2A lysine (K)-specific methyltransferase 2A
LAMB4 laminin, beta 4
LPPR2 lipid phosphate phosphatase-related protein type 2
LTC4S leukotriene C4 synthase
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MARK4 MAP/microtubule affinity-regulating kinase 4
MKL1 megakaryoblastic leukemia (translocation) 1
MOGAT2 monoacylglycerol O-acyltransferase 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NECAB2 N-terminal EF-hand calcium binding protein 2
NEUROD4 neuronal differentiation 4
NFIB nuclear factor I/B
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PGAP3 post-GPI attachment to proteins 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAC1 placenta-specific 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRDM1 PR domain containing 1, with ZNF domain
PRKG2 protein kinase, cGMP-dependent, type II
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RAP1GAP RAP1 GTPase activating protein
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SARM1 sterile alpha and TIR motif containing 1
SASH3 SAM and SH3 domain containing 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SGK2 serum/glucocorticoid regulated kinase 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SPTBN2 spectrin, beta, non-erythrocytic 2
SRPK2 SRSF protein kinase 2
STAT2 signal transducer and activator of transcription 2, 113kDa
STS steroid sulfatase (microsomal), isozyme S
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBX10 T-box 10
THRB thyroid hormone receptor, beta
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRPA1 transient receptor potential cation channel, subfamily A, member 1
USP2 ubiquitin specific peptidase 2
WNT10B wingless-type MMTV integration site family, member 10B
WNT16 wingless-type MMTV integration site family, member 16
WSCD1 WSC domain containing 1
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAMTSL3 ADAMTS-like 3
AHSP alpha hemoglobin stabilizing protein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANO2 anoctamin 2, calcium activated chloride channel
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AUTS2 autism susceptibility candidate 2
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALML5 calmodulin-like 5
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC134 coiled-coil domain containing 134
CCNO cyclin O
CD53 CD53 molecule
CD83 CD83 molecule
CEND1 cell cycle exit and neuronal differentiation 1
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLGN calmegin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DLL3 delta-like 3 (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK2 docking protein 2, 56kDa
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV7 ets variant 7
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM76A family with sequence similarity 76, member A
FBXO4 F-box protein 4
FER fer (fps/fes related) tyrosine kinase
FRMD1 FERM domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRTP1 growth hormone regulated TBC protein 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HLA-DMB major histocompatibility complex, class II, DM beta
HOXA4 homeobox A4
HOXB2 homeobox B2
HPN hepsin
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA17 interferon, alpha 17
IFT22 intraflagellar transport 22
IL2RB interleukin 2 receptor, beta
INHA inhibin, alpha
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK2 potassium channel, two pore domain subfamily K, member 2
KLHL25 kelch-like family member 25
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LSP1 lymphocyte-specific protein 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGEA5 melanoma antigen family A5
MMP13 matrix metallopeptidase 13
MORN1 MORN repeat containing 1
MRPL41 mitochondrial ribosomal protein L41
NCALD neurocalcin delta
NKX2-8 NK2 homeobox 8
NME5 NME/NM23 family member 5
NNAT neuronatin
NPFFR1 neuropeptide FF receptor 1
NPY4R neuropeptide Y receptor Y4
NR3C2 nuclear receptor subfamily 3, group C, member 2
PCDHB13 protocadherin beta 13
PRPH peripherin
RASL11B RAS-like, family 11, member B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFPL1S RFPL1 antisense RNA 1
RNF122 ring finger protein 122
RNF208 ring finger protein 208
RPL23AP32 ribosomal protein L23a pseudogene 32
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC35G2 solute carrier family 35, member G2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLPI secretory leukocyte peptidase inhibitor
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNCAIP synuclein, alpha interacting protein
SND1-IT1 SND1 intronic transcript 1
ST5 suppression of tumorigenicity 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBKBP1 TBK1 binding protein 1
TCTN2 tectonic family member 2
TFDP3 transcription factor Dp family, member 3
TMEM8B transmembrane protein 8B
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TUBA3C tubulin, alpha 3c
TYRP1 tyrosinase-related protein 1