fipexide-1560 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fipexide-1560 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ACAA2 acetyl-CoA acyltransferase 2
ACAN aggrecan
ACO1 aconitase 1, soluble
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATG4B autophagy related 4B, cysteine peptidase
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BMP7 bone morphogenetic protein 7
BNC2 basonuclin 2
CD84 CD84 molecule
CDK6 cyclin-dependent kinase 6
CLCN7 chloride channel, voltage-sensitive 7
CTRC chymotrypsin C (caldecrin)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DOK2 docking protein 2, 56kDa
DPH2 DPH2 homolog (S. cerevisiae)
ELK1 ELK1, member of ETS oncogene family
EPHB2 EPH receptor B2
EPS8L1 EPS8-like 1
FAM49A family with sequence similarity 49, member A
FGFBP1 fibroblast growth factor binding protein 1
FH fumarate hydratase
FPGS folylpolyglutamate synthase
GFOD2 glucose-fructose oxidoreductase domain containing 2
GIMAP5 GTPase, IMAP family member 5
GLB1L2 galactosidase, beta 1-like 2
GLRX3 glutaredoxin 3
GMEB1 glucocorticoid modulatory element binding protein 1
GSK3A glycogen synthase kinase 3 alpha
H2AFY H2A histone family, member Y
HTRA1 HtrA serine peptidase 1
IFITM1 interferon induced transmembrane protein 1
IGSF6 immunoglobulin superfamily, member 6
IL6R interleukin 6 receptor
INO80D INO80 complex subunit D
KAT6B K(lysine) acetyltransferase 6B
KIZ kizuna centrosomal protein
MBD3 methyl-CpG binding domain protein 3
MCL1 myeloid cell leukemia 1
MED6 mediator complex subunit 6
MISP mitotic spindle positioning
N4BP1 NEDD4 binding protein 1
NADK NAD kinase
NDRG2 NDRG family member 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NFYA nuclear transcription factor Y, alpha
NPAP1 nuclear pore associated protein 1
OBSL1 obscurin-like 1
ORC4 origin recognition complex, subunit 4
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PCDHB6 protocadherin beta 6
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PICK1 protein interacting with PRKCA 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLIN2 perilipin 2
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PSG3 pregnancy specific beta-1-glycoprotein 3
RAB11B RAB11B, member RAS oncogene family
RAB22A RAB22A, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
RGS10 regulator of G-protein signaling 10
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIC8A RIC8 guanine nucleotide exchange factor A
SAMM50 SAMM50 sorting and assembly machinery component
SCAPER S-phase cyclin A-associated protein in the ER
SDC2 syndecan 2
SEC31B SEC31 homolog B (S. cerevisiae)
SH3BP2 SH3-domain binding protein 2
SIRT5 sirtuin 5
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SMAD3 SMAD family member 3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPR signal recognition particle receptor (docking protein)
STX2 syntaxin 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBXA2R thromboxane A2 receptor
TCP11L1 t-complex 11, testis-specific-like 1
TET3 tet methylcytosine dioxygenase 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMC6 transmembrane channel-like 6
TMEM161A transmembrane protein 161A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TP53I3 tumor protein p53 inducible protein 3
TRA T cell receptor alpha locus
TRAF1 TNF receptor-associated factor 1
TRAF3IP2 TRAF3 interacting protein 2
TRAIP TRAF interacting protein
TTC23 tetratricopeptide repeat domain 23
TUFT1 tuftelin 1
ZC3H13 zinc finger CCCH-type containing 13

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACOT9 acyl-CoA thioesterase 9
ALPK1 alpha-kinase 1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOBR apolipoprotein B receptor
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
C19ORF24 chromosome 19 open reading frame 24
CCNE2 cyclin E2
CCP110 centriolar coiled coil protein 110kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CLEC2B C-type lectin domain family 2, member B
CTR9 CTR9, Paf1/RNA polymerase II complex component
DAAM1 dishevelled associated activator of morphogenesis 1
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DIXDC1 DIX domain containing 1
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DPYD dihydropyrimidine dehydrogenase
DYSF dysferlin
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERO1L ERO1-like (S. cerevisiae)
FAM222B family with sequence similarity 222, member B
FAM3C family with sequence similarity 3, member C
FBRS fibrosin
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
GBP2 guanylate binding protein 2, interferon-inducible
GPATCH2 G patch domain containing 2
GPR137B G protein-coupled receptor 137B
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIRA histone cell cycle regulator
HIST3H2A histone cluster 3, H2a
INPP5F inositol polyphosphate-5-phosphatase F
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0922 KIAA0922
KPNA4 karyopherin alpha 4 (importin alpha 3)
LIG1 ligase I, DNA, ATP-dependent
LSP1 lymphocyte-specific protein 1
LYRM2 LYR motif containing 2
LZTR1 leucine-zipper-like transcription regulator 1
MAGEF1 melanoma antigen family F1
MAGOHB mago-nashi homolog B (Drosophila)
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEAF6 MYST/Esa1-associated factor 6
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
MSN moesin
MTG1 mitochondrial ribosome-associated GTPase 1
MUTYH mutY homolog
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
ORC6 origin recognition complex, subunit 6
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK1IP1 PAK1 interacting protein 1
PARG poly (ADP-ribose) glycohydrolase
PCNA proliferating cell nuclear antigen
PISD phosphatidylserine decarboxylase
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLIN3 perilipin 3
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RANBP6 RAN binding protein 6
RBBP5 retinoblastoma binding protein 5
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC4 syndecan 4
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEC61B Sec61 beta subunit
SETMAR SET domain and mariner transposase fusion gene
SHCBP1 SHC SH2-domain binding protein 1
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SREBF1 sterol regulatory element binding transcription factor 1
STK39 serine threonine kinase 39
SUCO SUN domain containing ossification factor
SYF2 SYF2 pre-mRNA-splicing factor
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TJP2 tight junction protein 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRIM22 tripartite motif containing 22
TTC4 tetratricopeptide repeat domain 4
TUBA1A tubulin, alpha 1a
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
WDR82 WD repeat domain 82
WDYHV1 WDYHV motif containing 1
ZEB2 zinc finger E-box binding homeobox 2
ZNF140 zinc finger protein 140
ZNF264 zinc finger protein 264
ZNF33B zinc finger protein 33B
ZNF430 zinc finger protein 430
ZNF529 zinc finger protein 529
ZNF652 zinc finger protein 652