fipexide-5737 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the fipexide-5737 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
ARID5A AT rich interactive domain 5A (MRF1-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP9B ATPase, class II, type 9B
ATXN7L1 ataxin 7-like 1
BMP7 bone morphogenetic protein 7
C14ORF79 chromosome 14 open reading frame 79
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CD4 CD4 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CIC capicua transcriptional repressor
COL9A3 collagen, type IX, alpha 3
CSF1 colony stimulating factor 1 (macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTIF CBP80/20-dependent translation initiation factor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDO D-aspartate oxidase
DNAI2 dynein, axonemal, intermediate chain 2
EFNA3 ephrin-A3
EGR1 early growth response 1
ERAP1 endoplasmic reticulum aminopeptidase 1
EXOSC2 exosome component 2
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FLOT1 flotillin 1
FOXG1 forkhead box G1
GHRHR growth hormone releasing hormone receptor
GLP1R glucagon-like peptide 1 receptor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPC3 glypican 3
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR17 G protein-coupled receptor 17
GRK4 G protein-coupled receptor kinase 4
GRTP1 growth hormone regulated TBC protein 1
HAP1 huntingtin-associated protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCTD14 potassium channel tetramerization domain containing 14
KIF5A kinesin family member 5A
KLHL25 kelch-like family member 25
KRT34 keratin 34, type I
LAMA4 laminin, alpha 4
LEFTY1 left-right determination factor 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOX lysyl oxidase
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAU2 MAU2 sister chromatid cohesion factor
MEFV Mediterranean fever
MEP1B meprin A, beta
MPPE1 metallophosphoesterase 1
MRPS18C mitochondrial ribosomal protein S18C
MST1L macrophage stimulating 1-like
MUC7 mucin 7, secreted
MVB12B multivesicular body subunit 12B
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NR2E3 nuclear receptor subfamily 2, group E, member 3
PDE4A phosphodiesterase 4A, cAMP-specific
PELI2 pellino E3 ubiquitin protein ligase family member 2
PEX11A peroxisomal biogenesis factor 11 alpha
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRDM2 PR domain containing 2, with ZNF domain
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RAB11B RAB11B, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SH3BP2 SH3-domain binding protein 2
SIRT5 sirtuin 5
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLA Src-like-adaptor
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMAD7 SMAD family member 7
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOCS3 suppressor of cytokine signaling 3
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRCAP Snf2-related CREBBP activator protein
SSTR5 somatostatin receptor 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN4 stathmin-like 4
SV2B synaptic vesicle glycoprotein 2B
TBR1 T-box, brain, 1
TCF4 transcription factor 4
TOX thymocyte selection-associated high mobility group box
TP53I11 tumor protein p53 inducible protein 11
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
ZFPL1 zinc finger protein-like 1
ZNF3 zinc finger protein 3
ZNF334 zinc finger protein 334
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
AFAP1 actin filament associated protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARL15 ADP-ribosylation factor-like 15
ASIC3 acid sensing (proton gated) ion channel 3
BTC betacellulin
C4ORF29 chromosome 4 open reading frame 29
CA8 carbonic anhydrase VIII
CAPN5 calpain 5
CASP8AP2 caspase 8 associated protein 2
CCDC186 coiled-coil domain containing 186
CCNJL cyclin J-like
CD70 CD70 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDON cell adhesion associated, oncogene regulated
CEMIP cell migration inducing protein, hyaluronan binding
CENPO centromere protein O
CGREF1 cell growth regulator with EF-hand domain 1
CHKB choline kinase beta
CIDEC cell death-inducing DFFA-like effector c
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPED1 cadherin-like and PC-esterase domain containing 1
CRYBA2 crystallin, beta A2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCLRE1A DNA cross-link repair 1A
DNAL4 dynein, axonemal, light chain 4
DTX2 deltex 2, E3 ubiquitin ligase
ERAP2 endoplasmic reticulum aminopeptidase 2
ERCC4 excision repair cross-complementation group 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM155A family with sequence similarity 155, member A
FAM184A family with sequence similarity 184, member A
FANCC Fanconi anemia, complementation group C
FGL1 fibrinogen-like 1
FRS3 fibroblast growth factor receptor substrate 3
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GRB7 growth factor receptor-bound protein 7
HIST1H2BM histone cluster 1, H2bm
HIST1H3G histone cluster 1, H3g
IFI6 interferon, alpha-inducible protein 6
IL20RA interleukin 20 receptor, alpha
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT31 keratin 31, type I
LOC257152 uncharacterized LOC257152
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYPD3 LY6/PLAUR domain containing 3
MAGEB2 melanoma antigen family B2
MAGEF1 melanoma antigen family F1
MANSC1 MANSC domain containing 1
MAPK3 mitogen-activated protein kinase 3
MILR1 mast cell immunoglobulin-like receptor 1
MTA2 metastasis associated 1 family, member 2
MVD mevalonate (diphospho) decarboxylase
MYL5 myosin, light chain 5, regulatory
NBEAL2 neurobeachin-like 2
NLK nemo-like kinase
NME5 NME/NM23 family member 5
OLFML2A olfactomedin-like 2A
PAIP2B poly(A) binding protein interacting protein 2B
PDGFRL platelet-derived growth factor receptor-like
PER3 period circadian clock 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB4B RAB4B, member RAS oncogene family
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCGB2A2 secretoglobin, family 2A, member 2
SECISBP2 SECIS binding protein 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SETBP1 SET binding protein 1
SLC35F6 solute carrier family 35, member F6
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STEAP4 STEAP family member 4
SULT4A1 sulfotransferase family 4A, member 1
TENM1 teneurin transmembrane protein 1
THRAP3 thyroid hormone receptor associated protein 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMSB15A thymosin beta 15a
TRIM45 tripartite motif containing 45
UGT8 UDP glycosyltransferase 8
ZFP30 ZFP30 zinc finger protein
ZNF350 zinc finger protein 350
ZNF442 zinc finger protein 442
ZNF671 zinc finger protein 671
ZNF768 zinc finger protein 768