fisetin-579 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fisetin-579 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AOX1 aldehyde oxidase 1
APP amyloid beta (A4) precursor protein
AVEN apoptosis, caspase activation inhibitor
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
CAPN1 calpain 1, (mu/I) large subunit
CD248 CD248 molecule, endosialin
CD80 CD80 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFAP74 cilia and flagella associated protein 74
CHMP4A charged multivesicular body protein 4A
CIZ1 CDKN1A interacting zinc finger protein 1
CKLF chemokine-like factor
CLIC4 chloride intracellular channel 4
CLTB clathrin, light chain B
CRTAP cartilage associated protein
CTSF cathepsin F
CTSZ cathepsin Z
DKC1 dyskeratosis congenita 1, dyskerin
EGR4 early growth response 4
EMC1 ER membrane protein complex subunit 1
EMD emerin
ERCC2 excision repair cross-complementation group 2
FAM131B family with sequence similarity 131, member B
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
FOCAD focadhesin
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GAS7 growth arrest-specific 7
GLP1R glucagon-like peptide 1 receptor
GM2A GM2 ganglioside activator
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPATCH4 G patch domain containing 4
GPR137 G protein-coupled receptor 137
GRK6 G protein-coupled receptor kinase 6
GUK1 guanylate kinase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H4H histone cluster 1, H4h
HP1BP3 heterochromatin protein 1, binding protein 3
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB4 integrin, beta 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0894 KIAA0894 protein
KLK1 kallikrein 1
KRT86 keratin 86, type II
LMNA lamin A/C
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MBTPS1 membrane-bound transcription factor peptidase, site 1
MINK1 misshapen-like kinase 1
MRPL33 mitochondrial ribosomal protein L33
MRPS34 mitochondrial ribosomal protein S34
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NAAA N-acylethanolamine acid amidase
NADK NAD kinase
NECAB3 N-terminal EF-hand calcium binding protein 3
NPAS2 neuronal PAS domain protein 2
NPDC1 neural proliferation, differentiation and control, 1
NPTXR neuronal pentraxin receptor
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
ORAI2 ORAI calcium release-activated calcium modulator 2
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PADI1 peptidyl arginine deiminase, type I
PBX1 pre-B-cell leukemia homeobox 1
PI3 peptidase inhibitor 3, skin-derived
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR3 phospholipid scramblase 3
PLTP phospholipid transfer protein
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PYGB phosphorylase, glycogen; brain
RECQL4 RecQ protein-like 4
S100A11 S100 calcium binding protein A11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIDT1 SID1 transmembrane family, member 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STEAP3 STEAP family member 3, metalloreductase
TCF3 transcription factor 3
TGFA transforming growth factor, alpha
TMEM8B transmembrane protein 8B
TRAF3 TNF receptor-associated factor 3
TRBC1 T cell receptor beta constant 1
TRIO trio Rho guanine nucleotide exchange factor
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
TSTA3 tissue specific transplantation antigen P35B
TUBA3C tubulin, alpha 3c
TXNL4A thioredoxin-like 4A
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USP39 ubiquitin specific peptidase 39
WDR1 WD repeat domain 1
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANKRD17 ankyrin repeat domain 17
ARF6 ADP-ribosylation factor 6
BAG3 BCL2-associated athanogene 3
BCL10 B-cell CLL/lymphoma 10
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C11ORF68 chromosome 11 open reading frame 68
C14ORF169 chromosome 14 open reading frame 169
C2CD2 C2 calcium-dependent domain containing 2
CCNB1 cyclin B1
CDC42SE1 CDC42 small effector 1
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFAP20 cilia and flagella associated protein 20
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN4 claudin 4
CLP1 cleavage and polyadenylation factor I subunit 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP4 dual specificity phosphatase 4
EIF1B eukaryotic translation initiation factor 1B
EPHA2 EPH receptor A2
FADD Fas (TNFRSF6)-associated via death domain
FAM102A family with sequence similarity 102, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GCLM glutamate-cysteine ligase, modifier subunit
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMNN geminin, DNA replication inhibitor
GOLPH3 golgi phosphoprotein 3 (coat-protein)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HJURP Holliday junction recognition protein
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD1C jumonji domain containing 1C
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KLF10 Kruppel-like factor 10
KRCC1 lysine-rich coiled-coil 1
LRRC47 leucine rich repeat containing 47
LTN1 listerin E3 ubiquitin protein ligase 1
MAPK6 mitogen-activated protein kinase 6
MFAP1 microfibrillar-associated protein 1
MID1IP1 MID1 interacting protein 1
MTCL1 microtubule crosslinking factor 1
MTERF3 mitochondrial transcription termination factor 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA6 nuclear receptor coactivator 6
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PAPD7 PAP associated domain containing 7
PEX11B peroxisomal biogenesis factor 11 beta
PHC2 polyhomeotic homolog 2 (Drosophila)
PITPNB phosphatidylinositol transfer protein, beta
PNRC2 proline-rich nuclear receptor coactivator 2
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PTRH2 peptidyl-tRNA hydrolase 2
QRICH1 glutamine-rich 1
RBM7 RNA binding motif protein 7
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RIPK4 receptor-interacting serine-threonine kinase 4
RND3 Rho family GTPase 3
RNF103 ring finger protein 103
RNF139 ring finger protein 139
RNF4 ring finger protein 4
RPP14 ribonuclease P/MRP 14kDa subunit
SAC3D1 SAC3 domain containing 1
SERTAD2 SERTA domain containing 2
SETD1B SET domain containing 1B
SLC38A2 solute carrier family 38, member 2
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX9 SRY (sex determining region Y)-box 9
SRP19 signal recognition particle 19kDa
SRSF4 serine/arginine-rich splicing factor 4
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF672 zinc finger protein 672