flap endonuclease activity Gene Set

Dataset	GO Molecular Function Annotations 2025
Category	structural or functional annotations
Type	molecular function
Description	Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. (Gene Ontology, GO_0048256)
External Link	http://amigo.geneontology.org/amigo/term/GO:0048256
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Genes

7 genes performing the flap endonuclease activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol	Name
DNA2	DNA replication helicase/nuclease 2
EXO1	exonuclease 1
FAN1	FANCD2/FANCI-associated nuclease 1
FEN1	flap structure-specific endonuclease 1
GEN1	GEN1 Holliday junction 5' flap endonuclease
MUS81	MUS81 structure-specific endonuclease subunit
SLX1A	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)