flecainide-3418 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the flecainide-3418 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSF2 acyl-CoA synthetase family member 2
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAP1 ArfGAP with dual PH domains 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
APOM apolipoprotein M
ARHGAP1 Rho GTPase activating protein 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BHLHE41 basic helix-loop-helix family, member e41
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF95 chromosome 10 open reading frame 95
C14ORF79 chromosome 14 open reading frame 79
C21ORF2 chromosome 21 open reading frame 2
C3 complement component 3
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALB1 calbindin 1, 28kDa
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CCNJL cyclin J-like
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CERS4 ceramide synthase 4
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CTBP2 C-terminal binding protein 2
CTSF cathepsin F
DCAF8 DDB1 and CUL4 associated factor 8
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOC2A double C2-like domains, alpha
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ELAVL3 ELAV like neuron-specific RNA binding protein 3
FBXL6 F-box and leucine-rich repeat protein 6
FBXO2 F-box protein 2
FGFR1 fibroblast growth factor receptor 1
GAS2 growth arrest-specific 2
GIMAP5 GTPase, IMAP family member 5
GK glycerol kinase
GP6 glycoprotein VI (platelet)
GPATCH3 G patch domain containing 3
HIST1H4F histone cluster 1, H4f
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC5 homeobox C5
IQCK IQ motif containing K
ITM2C integral membrane protein 2C
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDM8 lysine (K)-specific demethylase 8
KIAA0040 KIAA0040
KIFC3 kinesin family member C3
LEPR leptin receptor
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPPE1 metallophosphoesterase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4DIP phosphodiesterase 4D interacting protein
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PMEL premelanosome protein
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PSD3 pleckstrin and Sec7 domain containing 3
RASL11B RAS-like, family 11, member B
RGS10 regulator of G-protein signaling 10
RND1 Rho family GTPase 1
RNF43 ring finger protein 43
RPL18 ribosomal protein L18
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
S100A8 S100 calcium binding protein A8
SCAMP1 secretory carrier membrane protein 1
SCAPER S-phase cyclin A-associated protein in the ER
SETD1A SET domain containing 1A
SOCS1 suppressor of cytokine signaling 1
SOCS6 suppressor of cytokine signaling 6
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBC1D22A TBC1 domain family, member 22A
TMEM242 transmembrane protein 242
TMOD1 tropomodulin 1
TPP1 tripeptidyl peptidase I
TRIM25 tripartite motif containing 25
UPK3B uroplakin 3B
VN1R1 vomeronasal 1 receptor 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF137P zinc finger protein 137, pseudogene
ZNF16 zinc finger protein 16
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ANKRD36 ankyrin repeat domain 36
ANKRD40 ankyrin repeat domain 40
ATF7IP2 activating transcription factor 7 interacting protein 2
BTBD2 BTB (POZ) domain containing 2
BTF3P12 basic transcription factor 3 pseudogene 12
C5 complement component 5
CAPN1 calpain 1, (mu/I) large subunit
CCDC25 coiled-coil domain containing 25
CDK3 cyclin-dependent kinase 3
CEP131 centrosomal protein 131kDa
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPPED1 calcineurin-like phosphoesterase domain containing 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DMXL1 Dmx-like 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DVL1 dishevelled segment polarity protein 1
EAF2 ELL associated factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOVL4 ELOVL fatty acid elongase 4
EPPK1 epiplakin 1
EVPL envoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM102A family with sequence similarity 102, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXW12 F-box and WD repeat domain containing 12
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
GDAP1 ganglioside induced differentiation associated protein 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIRA histone cell cycle regulator
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HOXC13 homeobox C13
HPS6 Hermansky-Pudlak syndrome 6
IFT81 intraflagellar transport 81
IL4R interleukin 4 receptor
IRX4 iroquois homeobox 4
KIAA0895 KIAA0895
KLHL36 kelch-like family member 36
KRI1 KRI1 homolog (S. cerevisiae)
LOC100287590 uncharacterized LOC100287590
LRP5 low density lipoprotein receptor-related protein 5
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC37A2 leucine rich repeat containing 37, member A2
LY6G5C lymphocyte antigen 6 complex, locus G5C
MANBA mannosidase, beta A, lysosomal
MATK megakaryocyte-associated tyrosine kinase
NMU neuromedin U
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
OGFRL1 opioid growth factor receptor-like 1
OSTF1 osteoclast stimulating factor 1
PCDHB3 protocadherin beta 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIBF1 progesterone immunomodulatory binding factor 1
POLH polymerase (DNA directed), eta
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRPH peripherin
PRR14L proline rich 14-like
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBM38 RNA binding motif protein 38
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIBC2 RIB43A domain with coiled-coils 2
RIN2 Ras and Rab interactor 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RRAGB Ras-related GTP binding B
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH2B3 SH2B adaptor protein 3
SIRT6 sirtuin 6
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMAD7 SMAD family member 7
SNHG3 small nucleolar RNA host gene 3
SPATA7 spermatogenesis associated 7
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TRABD TraB domain containing
TRAPPC11 trafficking protein particle complex 11
TTC30A tetratricopeptide repeat domain 30A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBED1 zinc finger, BED-type containing 1
ZBTB25 zinc finger and BTB domain containing 25
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFHX3 zinc finger homeobox 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF250 zinc finger protein 250
ZNF324 zinc finger protein 324
ZYX zyxin