flecainide-3761 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the flecainide-3761 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM22 ADAM metallopeptidase domain 22
AFP alpha-fetoprotein
AGRN agrin
ALOXE3 arachidonate lipoxygenase 3
AMH anti-Mullerian hormone
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BMP10 bone morphogenetic protein 10
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
CA5B carbonic anhydrase VB, mitochondrial
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL21 chemokine (C-C motif) ligand 21
CLTA clathrin, light chain A
CNGB3 cyclic nucleotide gated channel beta 3
CREBZF CREB/ATF bZIP transcription factor
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DES desmin
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
ERO1LB ERO1-like beta (S. cerevisiae)
F9 coagulation factor IX
FHL3 four and a half LIM domains 3
FLJ11292
FLRT2 fibronectin leucine rich transmembrane protein 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJB5 gap junction protein, beta 5, 31.1kDa
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GP5 glycoprotein V (platelet)
GPC3 glypican 3
GRAP GRB2-related adaptor protein
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
IFT27 intraflagellar transport 27
IGHA1 immunoglobulin heavy constant alpha 1
ITGB8 integrin, beta 8
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0319L KIAA0319-like
MAPK14 mitogen-activated protein kinase 14
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MUC16 mucin 16, cell surface associated
MXD4 MAX dimerization protein 4
NCDN neurochondrin
NKX3-2 NK3 homeobox 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRAP nebulin-related anchoring protein
OBSL1 obscurin-like 1
PARVA parvin, alpha
PGAP3 post-GPI attachment to proteins 3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRB4 proline-rich protein BstNI subfamily 4
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCI protein kinase C, iota
PRPH2 peripherin 2 (retinal degeneration, slow)
PSG4 pregnancy specific beta-1-glycoprotein 4
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTPRO protein tyrosine phosphatase, receptor type, O
PYY peptide YY
RAB5C RAB5C, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RND1 Rho family GTPase 1
RRAD Ras-related associated with diabetes
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHOX2 short stature homeobox 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRPB1 signal-regulatory protein beta 1
SLC17A4 solute carrier family 17, member 4
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
TAC3 tachykinin 3
TADA3 transcriptional adaptor 3
TBC1D22B TBC1 domain family, member 22B
TBCD tubulin folding cofactor D
TCP10 t-complex 10
TFDP3 transcription factor Dp family, member 3
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TOX thymocyte selection-associated high mobility group box
TRAF2 TNF receptor-associated factor 2
TRIM36 tripartite motif containing 36
TSGA10 testis specific, 10
WIZ widely interspaced zinc finger motifs
ZNF3 zinc finger protein 3
ZNF780B zinc finger protein 780B
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM23 ADAM metallopeptidase domain 23
ANXA10 annexin A10
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOL6 apolipoprotein L, 6
ARC activity-regulated cytoskeleton-associated protein
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASAP1-IT1 ASAP1 intronic transcript 1
ATF7IP2 activating transcription factor 7 interacting protein 2
CA11 carbonic anhydrase XI
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC132 coiled-coil domain containing 132
CHM choroideremia (Rab escort protein 1)
CHRM3 cholinergic receptor, muscarinic 3
CINP cyclin-dependent kinase 2 interacting protein
CORT cortistatin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSRNP3 cysteine-serine-rich nuclear protein 3
CUZD1 CUB and zona pellucida-like domains 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYB5R2 cytochrome b5 reductase 2
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCAF4 DDB1 and CUL4 associated factor 4
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS9 dehydrogenase/reductase (SDR family) member 9
ECM1 extracellular matrix protein 1
ELSPBP1 epididymal sperm binding protein 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FBXO31 F-box protein 31
FGL1 fibrinogen-like 1
GAS8 growth arrest-specific 8
GDAP1 ganglioside induced differentiation associated protein 1
GPR19 G protein-coupled receptor 19
GRAMD1C GRAM domain containing 1C
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAUS2 HAUS augmin-like complex, subunit 2
HIST1H2AB histone cluster 1, H2ab
HIST1H2AI histone cluster 1, H2ai
HIST1H4D histone cluster 1, H4d
HIST2H2AA3 histone cluster 2, H2aa3
HOXC11 homeobox C11
IFT81 intraflagellar transport 81
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD17 potassium channel tetramerization domain containing 17
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP4 low density lipoprotein receptor-related protein 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY86 lymphocyte antigen 86
MAGEF1 melanoma antigen family F1
NBEAL2 neurobeachin-like 2
NPFFR1 neuropeptide FF receptor 1
OGDHL oxoglutarate dehydrogenase-like
OVOL1 ovo-like zinc finger 1
PCBP4 poly(rC) binding protein 4
PGP phosphoglycolate phosphatase
PGPEP1 pyroglutamyl-peptidase I
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PITX2 paired-like homeodomain 2
PODXL2 podocalyxin-like 2
PRPH peripherin
PRR15L proline rich 15-like
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRS protein tyrosine phosphatase, receptor type, S
QSER1 glutamine and serine rich 1
RFPL3 ret finger protein-like 3
RNF25 ring finger protein 25
S100A3 S100 calcium binding protein A3
SARS2 seryl-tRNA synthetase 2, mitochondrial
SAYSD1 SAYSVFN motif domain containing 1
SCG2 secretogranin II
SCIN scinderin
SCUBE3 signal peptide, CUB domain, EGF-like 3
SELL selectin L
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNTA1 syntrophin, alpha 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STK16 serine/threonine kinase 16
STXBP5L syntaxin binding protein 5-like
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBX19 T-box 19
THRB thyroid hormone receptor, beta
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TSKU tsukushi, small leucine rich proteoglycan
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YPEL1 yippee-like 1 (Drosophila)
ZNF140 zinc finger protein 140
ZNF385D zinc finger protein 385D
ZNF573 zinc finger protein 573