fli1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Fli-1 proto-oncogene, ETS transcription factor|This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] (NCBI Entrez Gene Database, 2313)
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Genes

31 genes co-occuring with the biological term fli1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BCL2 B-cell CLL/lymphoma 2
CD34 CD34 molecule
COL1A2 collagen, type I, alpha 2
CTGF connective tissue growth factor
CTSB cathepsin B
DNMT1 DNA (cytosine-5-)-methyltransferase 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EP300 E1A binding protein p300
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLII flightless I homolog (Drosophila)
GATA1 GATA binding protein 1 (globin transcription factor 1)
GP6 glycoprotein VI (platelet)
HDAC1 histone deacetylase 1
HOXB4 homeobox B4
IL10 interleukin 10
JAK2 Janus kinase 2
KAT2B K(lysine) acetyltransferase 2B
KLF1 Kruppel-like factor 1 (erythroid)
MYH10 myosin, heavy chain 10, non-muscle
PDPN podoplanin
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PIAS2 protein inhibitor of activated STAT, 2
PLD2 phospholipase D2
PRKCD protein kinase C, delta
RUNX1 runt-related transcription factor 1
SMAD6 SMAD family member 6
TGFB1 transforming growth factor, beta 1
THPO thrombopoietin