flucloxacillin-5527 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the flucloxacillin-5527 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALOXE3 arachidonate lipoxygenase 3
ANGPTL2 angiopoietin-like 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOE apolipoprotein E
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
ATG13 autophagy related 13
BAX BCL2-associated X protein
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF63 chromosome 11 open reading frame 63
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CYHR1 cysteine/histidine-rich 1
DHODH dihydroorotate dehydrogenase (quinone)
ECEL1 endothelin converting enzyme-like 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDRF1 erythroid differentiation regulatory factor 1
ELOVL2 ELOVL fatty acid elongase 2
ETAA1 Ewing tumor-associated antigen 1
F5 coagulation factor V (proaccelerin, labile factor)
FGF16 fibroblast growth factor 16
FGFR4 fibroblast growth factor receptor 4
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GP5 glycoprotein V (platelet)
GPC3 glypican 3
GREB1L growth regulation by estrogen in breast cancer-like
GRM6 glutamate receptor, metabotropic 6
GSAP gamma-secretase activating protein
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HIRA histone cell cycle regulator
HNF1A HNF1 homeobox A
HSPG2 heparan sulfate proteoglycan 2
IFNA17 interferon, alpha 17
KANK1 KN motif and ankyrin repeat domains 1
KLF2 Kruppel-like factor 2
KRIT1 KRIT1, ankyrin repeat containing
KRT75 keratin 75, type II
LMNB1 lamin B1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MBD1 methyl-CpG binding domain protein 1
MBD2 methyl-CpG binding domain protein 2
MBNL2 muscleblind-like splicing regulator 2
N4BP3 NEDD4 binding protein 3
NHLH2 nescient helix loop helix 2
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUCB1 nucleobindin 1
NUP214 nucleoporin 214kDa
OSMR oncostatin M receptor
PAIP2B poly(A) binding protein interacting protein 2B
PER3 period circadian clock 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
POFUT1 protein O-fucosyltransferase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRB1 proline-rich protein BstNI subfamily 1
PRB4 proline-rich protein BstNI subfamily 4
QTRT1 queuine tRNA-ribosyltransferase 1
RAD51 RAD51 recombinase
RORC RAR-related orphan receptor C
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIDT2 SID1 transmembrane family, member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMAD4 SMAD family member 4
SNX29 sorting nexin 29
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRSF1 serine/arginine-rich splicing factor 1
SYBU syntabulin (syntaxin-interacting)
TBC1D22A TBC1 domain family, member 22A
TBX1 T-box 1
TCF20 transcription factor 20 (AR1)
TCP11L1 t-complex 11, testis-specific-like 1
TK2 thymidine kinase 2, mitochondrial
TMEM259 transmembrane protein 259
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX3 TOX high mobility group box family member 3
TREM2 triggering receptor expressed on myeloid cells 2
UNC119 unc-119 homolog (C. elegans)
VCAN versican
VIPR1 vasoactive intestinal peptide receptor 1
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB43 zinc finger and BTB domain containing 43
ZC3H7B zinc finger CCCH-type containing 7B
ZNF419 zinc finger protein 419
ZYX zyxin

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BTF3P12 basic transcription factor 3 pseudogene 12
C10ORF95 chromosome 10 open reading frame 95
C8ORF60 chromosome 8 open reading frame 60
CBR4 carbonyl reductase 4
CCDC130 coiled-coil domain containing 130
CCDC85C coiled-coil domain containing 85C
CCDC94 coiled-coil domain containing 94
CENPC centromere protein C
CFD complement factor D (adipsin)
CHKB choline kinase beta
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CTAGE5 CTAGE family, member 5
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DENND5A DENN/MADD domain containing 5A
DNAL4 dynein, axonemal, light chain 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERO1L ERO1-like (S. cerevisiae)
ETNK2 ethanolamine kinase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOC2 exocyst complex component 2
FAM189A2 family with sequence similarity 189, member A2
FANCE Fanconi anemia, complementation group E
FUZ fuzzy planar cell polarity protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPX2 glutathione peroxidase 2
GSTT1 glutathione S-transferase theta 1
HIST1H2AJ histone cluster 1, H2aj
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA1L heat shock 70kDa protein 1-like
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INTS9 integrator complex subunit 9
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA0513 KIAA0513
LAX1 lymphocyte transmembrane adaptor 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMO2 LIM domain only 2 (rhombotin-like 1)
LPXN leupaxin
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MGC12488
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5DC3 5'-nucleotidase domain containing 3
P3H1 prolyl 3-hydroxylase 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PGBD5 piggyBac transposable element derived 5
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKN1 protein kinase N1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
POM121 POM121 transmembrane nucleoporin
PPT2 palmitoyl-protein thioesterase 2
PRPH peripherin
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
R3HCC1L R3H domain and coiled-coil containing 1-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RANGRF RAN guanine nucleotide release factor
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A9 solute carrier family 12, member 9
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMG9 SMG9 nonsense mediated mRNA decay factor
SP140L SP140 nuclear body protein-like
SRPX sushi-repeat containing protein, X-linked
STARD13 StAR-related lipid transfer (START) domain containing 13
TAGLN transgelin
TLR5 toll-like receptor 5
TMEM183A transmembrane protein 183A
TMEM62 transmembrane protein 62
TNRC6B trinucleotide repeat containing 6B
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC30A tetratricopeptide repeat domain 30A
VAV1 vav 1 guanine nucleotide exchange factor
WDR62 WD repeat domain 62
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFHX2 zinc finger homeobox 2
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF350 zinc finger protein 350
ZNF365 zinc finger protein 365
ZNF586 zinc finger protein 586
ZNF668 zinc finger protein 668
ZNF8 zinc finger protein 8
ZSCAN31 zinc finger and SCAN domain containing 31