flunarizine-2381 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the flunarizine-2381 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRD2 adhesion G protein-coupled receptor D2
ADORA1 adenosine A1 receptor
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMN amnion associated transmembrane protein
ANXA2P3 annexin A2 pseudogene 3
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BMP8B bone morphogenetic protein 8b
CCDC28B coiled-coil domain containing 28B
CCL16 chemokine (C-C motif) ligand 16
CCL23 chemokine (C-C motif) ligand 23
CD79A CD79a molecule, immunoglobulin-associated alpha
CLIP2 CAP-GLY domain containing linker protein 2
CLPS colipase, pancreatic
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNTN5 contactin 5
COL15A1 collagen, type XV, alpha 1
CORO1B coronin, actin binding protein, 1B
CRISP2 cysteine-rich secretory protein 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCT dopachrome tautomerase
DDR1 discoidin domain receptor tyrosine kinase 1
DMWD dystrophia myotonica, WD repeat containing
DRAM1 DNA-damage regulated autophagy modulator 1
DSC3 desmocollin 3
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GYG2 glycogenin 2
HCFC1 host cell factor C1
HIST1H2BH histone cluster 1, H2bh
HIST1H3G histone cluster 1, H3g
HNF1B HNF1 homeobox B
HNMT histamine N-methyltransferase
HOMER2 homer scaffolding protein 2
HOXD11 homeobox D11
HPS1 Hermansky-Pudlak syndrome 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
ITPK1 inositol-tetrakisphosphate 1-kinase
KAZN kazrin, periplakin interacting protein
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT8P12 keratin 8 pseudogene 12
LAMP1 lysosomal-associated membrane protein 1
LARGE like-glycosyltransferase
LRRC31 leucine rich repeat containing 31
MAPK8 mitogen-activated protein kinase 8
MED16 mediator complex subunit 16
MNMIP1 manchette microtubule inner protein 1
MNX1 motor neuron and pancreas homeobox 1
MRPL41 mitochondrial ribosomal protein L41
MYOF myoferlin
NCKIPSD NCK interacting protein with SH3 domain
NR6A1 nuclear receptor subfamily 6, group A, member 1
OLFML2A olfactomedin-like 2A
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PER1 period circadian clock 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PHOX2A paired-like homeobox 2a
PIP prolactin-induced protein
PIPOX pipecolic acid oxidase
PPARA peroxisome proliferator-activated receptor alpha
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRLR prolactin receptor
PRUNE2 prune homolog 2 (Drosophila)
PTAFR platelet-activating factor receptor
PTCRA pre T-cell antigen receptor alpha
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RYK receptor-like tyrosine kinase
SAFB scaffold attachment factor B
SGK2 serum/glucocorticoid regulated kinase 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SP140 SP140 nuclear body protein
SPTBN4 spectrin, beta, non-erythrocytic 4
SSBP2 single-stranded DNA binding protein 2
STAT2 signal transducer and activator of transcription 2, 113kDa
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TAPBP TAP binding protein (tapasin)
TCF3 transcription factor 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF3IP2 TRAF3 interacting protein 2
TSC22D4 TSC22 domain family, member 4
TXK TXK tyrosine kinase
USB1 U6 snRNA biogenesis 1
VPRBP Vpr (HIV-1) binding protein
WNT10B wingless-type MMTV integration site family, member 10B
WSCD1 WSC domain containing 1
ZFX zinc finger protein, X-linked
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
AKTIP AKT interacting protein
ANO10 anoctamin 10
AOAH acyloxyacyl hydrolase (neutrophil)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APH1B APH1B gamma secretase subunit
ATAD2B ATPase family, AAA domain containing 2B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAK1 BCL2-antagonist/killer 1
C17ORF75 chromosome 17 open reading frame 75
CA11 carbonic anhydrase XI
CCDC176 coiled-coil domain containing 176
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CDC37L1 cell division cycle 37-like 1
CLSPN claspin
CPNE1 copine I
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSF1R colony stimulating factor 1 receptor
CXCR2 chemokine (C-X-C motif) receptor 2
DKK2 dickkopf WNT signaling pathway inhibitor 2
DMTF1 cyclin D binding myb-like transcription factor 1
DYM dymeclin
ELMO3 engulfment and cell motility 3
FAM114A1 family with sequence similarity 114, member A1
FAM222B family with sequence similarity 222, member B
FAM63A family with sequence similarity 63, member A
FBRS fibrosin
FBXL14 F-box and leucine-rich repeat protein 14
FOXN2 forkhead box N2
FURIN furin (paired basic amino acid cleaving enzyme)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GEMIN8 gem (nuclear organelle) associated protein 8
GIPC1 GIPC PDZ domain containing family, member 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GRIP2 glutamate receptor interacting protein 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HP haptoglobin
IL4R interleukin 4 receptor
IRF7 interferon regulatory factor 7
KAT2B K(lysine) acetyltransferase 2B
KIAA1024 KIAA1024
KLK5 kallikrein-related peptidase 5
LAX1 lymphocyte transmembrane adaptor 1
LIG4 ligase IV, DNA, ATP-dependent
LRRC20 leucine rich repeat containing 20
MANEA mannosidase, endo-alpha
MAP6D1 MAP6 domain containing 1
METTL21B methyltransferase like 21B
MFSD11 major facilitator superfamily domain containing 11
MGAM maltase-glucoamylase
MICA MHC class I polypeptide-related sequence A
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
PADI1 peptidyl arginine deiminase, type I
PAQR6 progestin and adipoQ receptor family member VI
PGM3 phosphoglucomutase 3
PKN1 protein kinase N1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLS1 plastin 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PRKG2 protein kinase, cGMP-dependent, type II
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTDSS2 phosphatidylserine synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB33B RAB33B, member RAS oncogene family
RNF121 ring finger protein 121
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL23AP7 ribosomal protein L23a pseudogene 7
SCAMP4 secretory carrier membrane protein 4
SFMBT1 Scm-like with four mbt domains 1
SLC22A14 solute carrier family 22, member 14
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STXBP1 syntaxin binding protein 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM159 transmembrane protein 159
TMEM209 transmembrane protein 209
TMEM8A transmembrane protein 8A
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRIM5 tripartite motif containing 5
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP19 ubiquitin specific peptidase 19
ZNF232 zinc finger protein 232
ZNF324 zinc finger protein 324
ZNF37BP zinc finger protein 37B, pseudogene
ZNF665 zinc finger protein 665
ZNF816 zinc finger protein 816