flunarizine-7013 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the flunarizine-7013 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ANKRD55 ankyrin repeat domain 55
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
C8A complement component 8, alpha polypeptide
CCNO cyclin O
CD302 CD302 molecule
CDC14A cell division cycle 14A
CDC25C cell division cycle 25C
CDK10 cyclin-dependent kinase 10
CHD3 chromodomain helicase DNA binding protein 3
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COPZ2 coatomer protein complex, subunit zeta 2
CYHR1 cysteine/histidine-rich 1
DDIT4 DNA-damage-inducible transcript 4
DESI2 desumoylating isopeptidase 2
DHRS12 dehydrogenase/reductase (SDR family) member 12
DMPK dystrophia myotonica-protein kinase
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPH5 diphthamide biosynthesis 5
EFNB3 ephrin-B3
EHD1 EH-domain containing 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FRMD4A FERM domain containing 4A
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS7 growth arrest-specific 7
GID4 GID complex subunit 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRB10 growth factor receptor-bound protein 10
HDGFRP3 hepatoma-derived growth factor, related protein 3
HPS1 Hermansky-Pudlak syndrome 1
IDS iduronate 2-sulfatase
IGHA1 immunoglobulin heavy constant alpha 1
IL6ST interleukin 6 signal transducer
INO80D INO80 complex subunit D
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA1107 KIAA1107
KLHL25 kelch-like family member 25
KRT15 keratin 15, type I
LIMCH1 LIM and calponin homology domains 1
LPPR2 lipid phosphate phosphatase-related protein type 2
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARK4 MAP/microtubule affinity-regulating kinase 4
MARS methionyl-tRNA synthetase
MAX MYC associated factor X
MGC12488
MTERF4 mitochondrial transcription termination factor 4
NDE1 nudE neurodevelopment protein 1
NF1 neurofibromin 1
NKX3-2 NK3 homeobox 2
NMT2 N-myristoyltransferase 2
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5DC3 5'-nucleotidase domain containing 3
PACS1 phosphofurin acidic cluster sorting protein 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PDCD6 programmed cell death 6
PDE4DIP phosphodiesterase 4D interacting protein
PHC1 polyhomeotic homolog 1 (Drosophila)
PHF20L1 PHD finger protein 20-like 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKNOX1 PBX/knotted 1 homeobox 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNPLA6 patatin-like phospholipase domain containing 6
PPAP2B phosphatidic acid phosphatase type 2B
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRB1 proline-rich protein BstNI subfamily 1
PRPF18 pre-mRNA processing factor 18
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPN6 protein tyrosine phosphatase, non-receptor type 6
QKI QKI, KH domain containing, RNA binding
RBM19 RNA binding motif protein 19
RER1 retention in endoplasmic reticulum sorting receptor 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SFRP4 secreted frizzled-related protein 4
SGSH N-sulfoglucosamine sulfohydrolase
SIK3 SIK family kinase 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SOWAHC sosondowah ankyrin repeat domain family member C
STAT5B signal transducer and activator of transcription 5B
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TTC9 tetratricopeptide repeat domain 9
UBXN1 UBX domain protein 1
UTRN utrophin
VAV1 vav 1 guanine nucleotide exchange factor
VEZT vezatin, adherens junctions transmembrane protein
ZBED1 zinc finger, BED-type containing 1
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ANAPC2 anaphase promoting complex subunit 2
APOO apolipoprotein O
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATAD5 ATPase family, AAA domain containing 5
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAK1 BCL2-antagonist/killer 1
BBS1 Bardet-Biedl syndrome 1
BCAS1 breast carcinoma amplified sequence 1
C16ORF45 chromosome 16 open reading frame 45
C3ORF52 chromosome 3 open reading frame 52
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CHMP6 charged multivesicular body protein 6
CLDN9 claudin 9
COBL cordon-bleu WH2 repeat protein
CUEDC1 CUE domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DSCAM Down syndrome cell adhesion molecule
EFNA3 ephrin-A3
FAM86C1 family with sequence similarity 86, member C1
FANCE Fanconi anemia, complementation group E
FBXW12 F-box and WD repeat domain containing 12
GALK1 galactokinase 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLCE glucuronic acid epimerase
GPHN gephyrin
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H2AG histone cluster 1, H2ag
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HPSE heparanase
HSPA4L heat shock 70kDa protein 4-like
IL10RB interleukin 10 receptor, beta
IPO13 importin 13
IREB2 iron-responsive element binding protein 2
IRF2 interferon regulatory factor 2
IRF7 interferon regulatory factor 7
JUNB jun B proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KIAA0125 KIAA0125
KLHL12 kelch-like family member 12
LARS leucyl-tRNA synthetase
LIN7B lin-7 homolog B (C. elegans)
LMCD1 LIM and cysteine-rich domains 1
LRRC61 leucine rich repeat containing 61
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARC2 mitochondrial amidoxime reducing component 2
METTL16 methyltransferase like 16
MFSD12 major facilitator superfamily domain containing 12
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTCL1 microtubule crosslinking factor 1
MTRF1 mitochondrial translational release factor 1
MYO19 myosin XIX
MYO9A myosin IXA
NARFL nuclear prelamin A recognition factor-like
NECAB3 N-terminal EF-hand calcium binding protein 3
NECAP2 NECAP endocytosis associated 2
NES nestin
NTHL1 nth endonuclease III-like 1 (E. coli)
OXTR oxytocin receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCDHB3 protocadherin beta 3
PEX26 peroxisomal biogenesis factor 26
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G10 phospholipase A2, group X
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB8B RAB8B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBL1 retinoblastoma-like 1
REEP4 receptor accessory protein 4
SALL2 spalt-like transcription factor 2
SETD1B SET domain containing 1B
SHPK sedoheptulokinase
SIRAL2 SIR2 antiphage like 2
SLC12A9 solute carrier family 12, member 9
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STBD1 starch binding domain 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TDRD3 tudor domain containing 3
TESK2 testis-specific kinase 2
TMEM184C transmembrane protein 184C
TMEM2 transmembrane protein 2
TNRC6B trinucleotide repeat containing 6B
TPST2 tyrosylprotein sulfotransferase 2
TWF2 twinfilin actin binding protein 2
URM1 ubiquitin related modifier 1
VWA1 von Willebrand factor A domain containing 1
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675
ZNF813 zinc finger protein 813
ZNHIT2 zinc finger, HIT-type containing 2