flunarizine-7412 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the flunarizine-7412 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ACOT11 acyl-CoA thioesterase 11
ADAP2 ArfGAP with dual PH domains 2
AIM1L absent in melanoma 1-like
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APOLD1 apolipoprotein L domain containing 1
AR androgen receptor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATP11A ATPase, class VI, type 11A
AURKA aurora kinase A
BCAM basal cell adhesion molecule (Lutheran blood group)
BIN1 bridging integrator 1
C5ORF45 chromosome 5 open reading frame 45
CBX7 chromobox homolog 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CHPF2 chondroitin polymerizing factor 2
CREBZF CREB/ATF bZIP transcription factor
CTAGE9 CTAGE family, member 9
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUL9 cullin 9
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DLX2 distal-less homeobox 2
DOK4 docking protein 4
DST dystonin
ESRRA estrogen-related receptor alpha
FADS3 fatty acid desaturase 3
FAM49B family with sequence similarity 49, member B
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GADD45B growth arrest and DNA-damage-inducible, beta
GPATCH2L G patch domain containing 2-like
GRTP1 growth hormone regulated TBC protein 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HFE hemochromatosis
HPS4 Hermansky-Pudlak syndrome 4
IL4R interleukin 4 receptor
INHBE inhibin, beta E
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
KAT2A K(lysine) acetyltransferase 2A
LOC730101 uncharacterized LOC730101
LRRC37A3 leucine rich repeat containing 37, member A3
LTK leukocyte receptor tyrosine kinase
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MPZL1 myelin protein zero-like 1
MTMR3 myotubularin related protein 3
MXD4 MAX dimerization protein 4
MZF1 myeloid zinc finger 1
N4BP3 NEDD4 binding protein 3
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPH2 non-SMC condensin II complex, subunit H2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OTUD3 OTU deubiquitinase 3
OVOL2 ovo-like zinc finger 2
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PTPRF protein tyrosine phosphatase, receptor type, F
RAB36 RAB36, member RAS oncogene family
RANBP3 RAN binding protein 3
RBM34 RNA binding motif protein 34
REPS2 RALBP1 associated Eps domain containing 2
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS12 regulator of G-protein signaling 12
RNF19B ring finger protein 19B
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
RUFY3 RUN and FYVE domain containing 3
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX7 syntaxin 7
SYNGR1 synaptogyrin 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBX19 T-box 19
THBD thrombomodulin
TLE4 transducin-like enhancer of split 4
TMEM62 transmembrane protein 62
TMEM63A transmembrane protein 63A
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTLL5 tubulin tyrosine ligase-like family member 5
UPP1 uridine phosphorylase 1
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP34 ubiquitin specific peptidase 34
UTRN utrophin
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VLDLR very low density lipoprotein receptor
WSB1 WD repeat and SOCS box containing 1
YY2 YY2 transcription factor
ZBTB7B zinc finger and BTB domain containing 7B
ZNF571 zinc finger protein 571
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACYP1 acylphosphatase 1, erythrocyte (common) type
ALDOC aldolase C, fructose-bisphosphate
ATG4A autophagy related 4A, cysteine peptidase
BAGE B melanoma antigen
BAHD1 bromo adjacent homology domain containing 1
BCORL1 BCL6 corepressor-like 1
BIN3 bridging integrator 3
C19ORF40 chromosome 19 open reading frame 40
C6ORF47 chromosome 6 open reading frame 47
CARD8 caspase recruitment domain family, member 8
CBX8 chromobox homolog 8
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CINP cyclin-dependent kinase 2 interacting protein
CRTAP cartilage associated protein
CTSV cathepsin V
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DHDDS dehydrodolichyl diphosphate synthase
DSCAM Down syndrome cell adhesion molecule
EDC3 enhancer of mRNA decapping 3
EFHD1 EF-hand domain family, member D1
EMD emerin
FA2H fatty acid 2-hydroxylase
FAIM Fas apoptotic inhibitory molecule
FAM63A family with sequence similarity 63, member A
FANCC Fanconi anemia, complementation group C
FHOD1 formin homology 2 domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FPGS folylpolyglutamate synthase
FURIN furin (paired basic amino acid cleaving enzyme)
GALE UDP-galactose-4-epimerase
GLTP glycolipid transfer protein
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GRB7 growth factor receptor-bound protein 7
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HHLA3 HERV-H LTR-associating 3
HIRA histone cell cycle regulator
HLA-J major histocompatibility complex, class I, J (pseudogene)
HSPA2 heat shock 70kDa protein 2
HYAL2 hyaluronoglucosaminidase 2
KCTD20 potassium channel tetramerization domain containing 20
KRI1 KRI1 homolog (S. cerevisiae)
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MBNL3 muscleblind-like splicing regulator 3
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCMBP minichromosome maintenance complex binding protein
METTL16 methyltransferase like 16
MICALL2 MICAL-like 2
MMD monocyte to macrophage differentiation-associated
MPI mannose phosphate isomerase
MTG1 mitochondrial ribosome-associated GTPase 1
MYO1E myosin IE
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
ODF2 outer dense fiber of sperm tails 2
OSMR oncostatin M receptor
PADI2 peptidyl arginine deiminase, type II
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGP phosphoglycolate phosphatase
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRICKLE3 prickle homolog 3 (Drosophila)
PRR3 proline rich 3
PYCRL pyrroline-5-carboxylate reductase-like
RBM41 RNA binding motif protein 41
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SCD5 stearoyl-CoA desaturase 5
SETD6 SET domain containing 6
SETMAR SET domain and mariner transposase fusion gene
SH2D4A SH2 domain containing 4A
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC41A3 solute carrier family 41, member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TBC1D17 TBC1 domain family, member 17
TBCCD1 TBCC domain containing 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR4 WD repeat domain 4
ZBED1 zinc finger, BED-type containing 1
ZMAT5 zinc finger, matrin-type 5
ZNF226 zinc finger protein 226
ZNF510 zinc finger protein 510
ZNF611 zinc finger protein 611