fluphenazine-1075 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the fluphenazine-1075 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APAF1 apoptotic peptidase activating factor 1
AQP3 aquaporin 3 (Gill blood group)
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ASPH aspartate beta-hydroxylase
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATG13 autophagy related 13
ATP9A ATPase, class II, type 9A
ATXN3 ataxin 3
BHLHE40 basic helix-loop-helix family, member e40
CAPN15 calpain 15
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD6 CD6 molecule
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCF1 cardiotrophin-like cytokine factor 1
CLK1 CDC-like kinase 1
CPD carboxypeptidase D
CXORF56 chromosome X open reading frame 56
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSE dermatan sulfate epimerase
DSPP dentin sialophosphoprotein
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELF4 E74-like factor 4 (ets domain transcription factor)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FKBP14 FK506 binding protein 14, 22 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LINC00339 long intergenic non-protein coding RNA 339
LPIN1 lipin 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC40 leucine rich repeat containing 40
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MIR22HG MIR22 host gene
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSMO1 methylsterol monooxygenase 1
MTCL1 microtubule crosslinking factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVK mevalonate kinase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PHC3 polyhomeotic homolog 3 (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB5B RAB5B, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RPGR retinitis pigmentosa GTPase regulator
RPLP2 ribosomal protein, large, P2
RXRB retinoid X receptor, beta
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPAG8 sperm associated antigen 8
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SUGP1 SURP and G patch domain containing 1
SUGP2 SURP and G patch domain containing 2
TOP3A topoisomerase (DNA) III alpha
TRIM2 tripartite motif containing 2
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBXN6 UBX domain protein 6
USP36 ubiquitin specific peptidase 36
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMYM5 zinc finger, MYM-type 5

decreased expression

Symbol Name
AKIP1 A kinase (PRKA) interacting protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
APIP APAF1 interacting protein
ARHGAP11A Rho GTPase activating protein 11A
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
BMS1 BMS1 ribosome biogenesis factor
BRD9 bromodomain containing 9
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C14ORF169 chromosome 14 open reading frame 169
C1ORF115 chromosome 1 open reading frame 115
C3ORF52 chromosome 3 open reading frame 52
C4ORF19 chromosome 4 open reading frame 19
C9ORF91 chromosome 9 open reading frame 91
CBR4 carbonyl reductase 4
CCDC91 coiled-coil domain containing 91
CCNE1 cyclin E1
CDT1 chromatin licensing and DNA replication factor 1
CEP83 centrosomal protein 83kDa
CEPT1 choline/ethanolamine phosphotransferase 1
CPOX coproporphyrinogen oxidase
CTPS1 CTP synthase 1
CTSV cathepsin V
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCK deoxycytidine kinase
DHDDS dehydrodolichyl diphosphate synthase
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
ECHDC3 enoyl CoA hydratase domain containing 3
EPS8L2 EPS8-like 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM188A family with sequence similarity 188, member A
FAM86B1 family with sequence similarity 86, member B1
FOXC1 forkhead box C1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GHR growth hormone receptor
GRB2 growth factor receptor-bound protein 2
GRWD1 glutamate-rich WD repeat containing 1
HEATR3 HEAT repeat containing 3
ICE2 interactor of little elongation complex ELL subunit 2
JADE3 jade family PHD finger 3
KLHL21 kelch-like family member 21
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP6D1 MAP6 domain containing 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MINPP1 multiple inositol-polyphosphate phosphatase 1
MIS18BP1 MIS18 binding protein 1
MOCS3 molybdenum cofactor synthesis 3
MSRA methionine sulfoxide reductase A
MT1HL1 metallothionein 1H-like 1
MUT methylmalonyl CoA mutase
NABP2 nucleic acid binding protein 2
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCAPD3 non-SMC condensin II complex, subunit D3
NCSTN nicastrin
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NFS1 NFS1 cysteine desulfurase
NPY1R neuropeptide Y receptor Y1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NT5DC2 5'-nucleotidase domain containing 2
OXSR1 oxidative stress responsive 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCYOX1 prenylcysteine oxidase 1
PEX12 peroxisomal biogenesis factor 12
PHACTR4 phosphatase and actin regulator 4
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
PRMT7 protein arginine methyltransferase 7
RINT1 RAD50 interactor 1
RNMTL1 RNA methyltransferase like 1
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
SAV1 salvador family WW domain containing protein 1
SCAP SREBF chaperone
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SPAG1 sperm associated antigen 1
SPANXC SPANX family, member C
SUMO4 small ubiquitin-like modifier 4
TCTA T-cell leukemia translocation altered
TET3 tet methylcytosine dioxygenase 3
TGS1 trimethylguanosine synthase 1
THEM6 thioesterase superfamily member 6
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM132A transmembrane protein 132A
TMEM168 transmembrane protein 168
TOR3A torsin family 3, member A
TRAF5 TNF receptor-associated factor 5
TRIOBP TRIO and F-actin binding protein
TTC27 tetratricopeptide repeat domain 27
TTC31 tetratricopeptide repeat domain 31
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR18 WD repeat domain 18
WDR43 WD repeat domain 43
WDR46 WD repeat domain 46
ZNF33B zinc finger protein 33B
ZNF83 zinc finger protein 83