fluphenazine-1178 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the fluphenazine-1178 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACAN aggrecan
ADGRA2 adhesion G protein-coupled receptor A2
AIM1L absent in melanoma 1-like
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKFY1 ankyrin repeat and FYVE domain containing 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP1 Rho GTPase activating protein 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATN1 atrophin 1
ATP10A ATPase, class V, type 10A
C19ORF54 chromosome 19 open reading frame 54
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD180 CD180 molecule
CD59 CD59 molecule, complement regulatory protein
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNS cystinosin, lysosomal cystine transporter
CUX1 cut-like homeobox 1
CXCR3 chemokine (C-X-C motif) receptor 3
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DKK2 dickkopf WNT signaling pathway inhibitor 2
DOCK5 dedicator of cytokinesis 5
EHD1 EH-domain containing 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELSPBP1 epididymal sperm binding protein 1
EXOC7 exocyst complex component 7
FBP1 fructose-1,6-bisphosphatase 1
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLOT1 flotillin 1
GALK1 galactokinase 1
GDF5 growth differentiation factor 5
HIST1H2BC histone cluster 1, H2bc
HLA-DOA major histocompatibility complex, class II, DO alpha
HSPA1L heat shock 70kDa protein 1-like
IL3RA interleukin 3 receptor, alpha (low affinity)
IL6R interleukin 6 receptor
INHBA inhibin, beta A
INPP5K inositol polyphosphate-5-phosphatase K
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0753 KIAA0753
KRAS Kirsten rat sarcoma viral oncogene homolog
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LGALS4 lectin, galactoside-binding, soluble, 4
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
METTL7A methyltransferase like 7A
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVK mevalonate kinase
MYO1E myosin IE
NEK9 NIMA-related kinase 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRP1 neuropilin 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP16 poly (ADP-ribose) polymerase family, member 16
PCNX pecanex homolog (Drosophila)
PDLIM7 PDZ and LIM domain 7 (enigma)
PEG3 paternally expressed 3
PEX1 peroxisomal biogenesis factor 1
PHTF2 putative homeodomain transcription factor 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTGDR2 prostaglandin D2 receptor 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PWAR5 Prader Willi/Angelman region RNA 5
REST RE1-silencing transcription factor
RNF126P1 ring finger protein 126 pseudogene 1
SCARB2 scavenger receptor class B, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SLAMF7 SLAM family member 7
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNX13 sorting nexin 13
SOX12 SRY (sex determining region Y)-box 12
SPHK1 sphingosine kinase 1
STS steroid sulfatase (microsomal), isozyme S
STX7 syntaxin 7
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TEP1 telomerase-associated protein 1
TMOD1 tropomodulin 1
TOX4 TOX high mobility group box family member 4
TPRA1 transmembrane protein, adipocyte asscociated 1
TUBA4B tubulin, alpha 4b
TULP3 tubby like protein 3
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAC14 Vac14 homolog (S. cerevisiae)
ZMYM5 zinc finger, MYM-type 5
ZNF606 zinc finger protein 606
ZNF609 zinc finger protein 609
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
AEN apoptosis enhancing nuclease
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP4 Rho GTPase activating protein 4
C11ORF68 chromosome 11 open reading frame 68
C17ORF70 chromosome 17 open reading frame 70
C1QTNF3 C1q and tumor necrosis factor related protein 3
C2CD2 C2 calcium-dependent domain containing 2
C9ORF3 chromosome 9 open reading frame 3
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN15 calpain 15
CARD9 caspase recruitment domain family, member 9
CCDC88C coiled-coil domain containing 88C
CCNJ cyclin J
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD320 CD320 molecule
CDC37L1 cell division cycle 37-like 1
CENPB centromere protein B, 80kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
CLEC4E C-type lectin domain family 4, member E
CLUH clustered mitochondria (cluA/CLU1) homolog
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CORO7 coronin 7
CRIP1 cysteine-rich protein 1 (intestinal)
CTSD cathepsin D
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND4C DENN/MADD domain containing 4C
ECSIT ECSIT signalling integrator
EFTUD1 elongation factor Tu GTP binding domain containing 1
ENO2 enolase 2 (gamma, neuronal)
ERCC8 excision repair cross-complementation group 8
ERI3 ERI1 exoribonuclease family member 3
ERO1LB ERO1-like beta (S. cerevisiae)
FAM53B family with sequence similarity 53, member B
FASTKD5 FAST kinase domains 5
FBXL7 F-box and leucine-rich repeat protein 7
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
GMEB1 glucocorticoid modulatory element binding protein 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPR27 G protein-coupled receptor 27
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HCFC2 host cell factor C2
HRAS Harvey rat sarcoma viral oncogene homolog
IL4R interleukin 4 receptor
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCTD15 potassium channel tetramerization domain containing 15
LINS lines homolog (Drosophila)
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAST3 microtubule associated serine/threonine kinase 3
MCTP2 multiple C2 domains, transmembrane 2
METTL8 methyltransferase like 8
MREG melanoregulin
MTERF4 mitochondrial transcription termination factor 4
MTG1 mitochondrial ribosome-associated GTPase 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NSD1 nuclear receptor binding SET domain protein 1
NSUN6 NOP2/Sun domain family, member 6
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDGFD platelet derived growth factor D
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNOC prepronociceptin
PRDM13 PR domain containing 13
PROS1 protein S (alpha)
RAB20 RAB20, member RAS oncogene family
RETN resistin
RGS19 regulator of G-protein signaling 19
RRP1 ribosomal RNA processing 1
SAMD9 sterile alpha motif domain containing 9
SEC31B SEC31 homolog B (S. cerevisiae)
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SPATA2L spermatogenesis associated 2-like
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STEAP3 STEAP family member 3, metalloreductase
TBXAS1 thromboxane A synthase 1 (platelet)
TERT telomerase reverse transcriptase
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM104 transmembrane protein 104
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSC22D1 TSC22 domain family, member 1
TUBA3C tubulin, alpha 3c
ULK1 unc-51 like autophagy activating kinase 1
USB1 U6 snRNA biogenesis 1
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VANGL1 VANGL planar cell polarity protein 1
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WBSCR16 Williams-Beuren syndrome chromosome region 16
ZBED1 zinc finger, BED-type containing 1
ZDHHC18 zinc finger, DHHC-type containing 18
ZMAT3 zinc finger, matrin-type 3
ZNF143 zinc finger protein 143
ZNF318 zinc finger protein 318
ZNF580 zinc finger protein 580