fluphenazine-1237 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fluphenazine-1237 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AMDHD2 amidohydrolase domain containing 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
ARTN artemin
C19ORF60 chromosome 19 open reading frame 60
C1ORF54 chromosome 1 open reading frame 54
CAPN10 calpain 10
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNT2 cyclin T2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHMP6 charged multivesicular body protein 6
CIDEB cell death-inducing DFFA-like effector b
CLEC2B C-type lectin domain family 2, member B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTAGE5 CTAGE family, member 5
CTNS cystinosin, lysosomal cystine transporter
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS12 dehydrogenase/reductase (SDR family) member 12
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EFNB3 ephrin-B3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERAP1 endoplasmic reticulum aminopeptidase 1
FABP3 fatty acid binding protein 3, muscle and heart
FAM174B family with sequence similarity 174, member B
FGF6 fibroblast growth factor 6
FOS FBJ murine osteosarcoma viral oncogene homolog
GPR137 G protein-coupled receptor 137
HDAC11 histone deacetylase 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHIPL2 HHIP-like 2
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HOXC5 homeobox C5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1A interleukin 1, alpha
IL24 interleukin 24
ING2 inhibitor of growth family, member 2
ING4 inhibitor of growth family, member 4
INSIG1 insulin induced gene 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KRT16 keratin 16, type I
LMF1 lipase maturation factor 1
LMF2 lipase maturation factor 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1S microtubule-associated protein 1S
MAP3K7CL MAP3K7 C-terminal like
MEGF9 multiple EGF-like-domains 9
METTL5 methyltransferase like 5
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MLYCD malonyl-CoA decarboxylase
MORN1 MORN repeat containing 1
MRAS muscle RAS oncogene homolog
MTA1 metastasis associated 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCAPH2 non-SMC condensin II complex, subunit H2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBP2 oxysterol binding protein 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCM1 pericentriolar material 1
PDGFB platelet-derived growth factor beta polypeptide
PILRA paired immunoglobin-like type 2 receptor alpha
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PNMA2 paraneoplastic Ma antigen 2
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTAFR platelet-activating factor receptor
RGS14 regulator of G-protein signaling 14
RPS17P5 ribosomal protein S17 pseudogene 5
RTEL1 regulator of telomere elongation helicase 1
SBF1 SET binding factor 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
TBXA2R thromboxane A2 receptor
TIMELESS timeless circadian clock
TJP3 tight junction protein 3
TLE2 transducin-like enhancer of split 2
TLR2 toll-like receptor 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM212 transmembrane protein 212
TMEM231 transmembrane protein 231
TMEM259 transmembrane protein 259
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS4 tensin 4
TRABD TraB domain containing
TRIM29 tripartite motif containing 29
USB1 U6 snRNA biogenesis 1
VWA1 von Willebrand factor A domain containing 1
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACBD4 acyl-CoA binding domain containing 4
AFAP1 actin filament associated protein 1
ANOS1 anosmin 1
ANXA2P3 annexin A2 pseudogene 3
APOLD1 apolipoprotein L domain containing 1
ARRB2 arrestin, beta 2
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BMP4 bone morphogenetic protein 4
C17ORF53 chromosome 17 open reading frame 53
CA11 carbonic anhydrase XI
CADPS2 Ca++-dependent secretion activator 2
CAMTA2 calmodulin binding transcription activator 2
CCNT1 cyclin T1
CEP72 centrosomal protein 72kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHST10 carbohydrate sulfotransferase 10
CLCN5 chloride channel, voltage-sensitive 5
CNTNAP3B contactin associated protein-like 3B
COBL cordon-bleu WH2 repeat protein
CUL9 cullin 9
DENND4A DENN/MADD domain containing 4A
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP8 dual specificity phosphatase 8
E2F8 E2F transcription factor 8
EFNA3 ephrin-A3
ERF Ets2 repressor factor
FAM120C family with sequence similarity 120C
FAM169A family with sequence similarity 169, member A
GPR1 G protein-coupled receptor 1
GRWD1 glutamate-rich WD repeat containing 1
HIRIP3 HIRA interacting protein 3
HOMER2 homer scaffolding protein 2
HOXA2 homeobox A2
HOXC10 homeobox C10
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA0753 KIAA0753
KIAA1107 KIAA1107
LPAR3 lysophosphatidic acid receptor 3
LRP5L low density lipoprotein receptor-related protein 5-like
LYPD1 LY6/PLAUR domain containing 1
MAGEF1 melanoma antigen family F1
MANBA mannosidase, beta A, lysosomal
MATN3 matrilin 3
MED15 mediator complex subunit 15
MEIS1 Meis homeobox 1
MFSD6 major facilitator superfamily domain containing 6
MILR1 mast cell immunoglobulin-like receptor 1
MMP9 matrix metallopeptidase 9
MNS1 meiosis-specific nuclear structural 1
MOB3B MOB kinase activator 3B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL28 mitochondrial ribosomal protein L28
MRPL44 mitochondrial ribosomal protein L44
MTERF4 mitochondrial transcription termination factor 4
NDP Norrie disease (pseudoglioma)
NOL12 nucleolar protein 12
OLFML2A olfactomedin-like 2A
PALMD palmdelphin
PARD6A par-6 family cell polarity regulator alpha
PARN poly(A)-specific ribonuclease
PARP16 poly (ADP-ribose) polymerase family, member 16
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRPH peripherin
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
PTGFR prostaglandin F receptor (FP)
RAB33B RAB33B, member RAS oncogene family
RNF2 ring finger protein 2
RNF31 ring finger protein 31
SCRN3 secernin 3
SERTAD3 SERTA domain containing 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SPAG16 sperm associated antigen 16
SPEG SPEG complex locus
STAG3 stromal antigen 3
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TGFB3 transforming growth factor, beta 3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM132A transmembrane protein 132A
TMEM62 transmembrane protein 62
TXLNG taxilin gamma
UBA5 ubiquitin-like modifier activating enzyme 5
USP18 ubiquitin specific peptidase 18
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6 ubiquitin specific peptidase 6
ZBTB48 zinc finger and BTB domain containing 48
ZNF669 zinc finger protein 669
ZNF770 zinc finger protein 770
ZNF8 zinc finger protein 8
ZSCAN5A zinc finger and SCAN domain containing 5A