fluphenazine-1662 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fluphenazine-1662 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AAGAB alpha- and gamma-adaptin binding protein
ACTL8 actin-like 8
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKMY1 ankyrin repeat and MYND domain containing 1
ANKRD11 ankyrin repeat domain 11
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARHGAP35 Rho GTPase activating protein 35
ATF3 activating transcription factor 3
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BHLHE40 basic helix-loop-helix family, member e40
BICD1 bicaudal D homolog 1 (Drosophila)
CA4 carbonic anhydrase IV
CASZ1 castor zinc finger 1
CD47 CD47 molecule
CDK3 cyclin-dependent kinase 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DDIT4 DNA-damage-inducible transcript 4
DMC1 DNA meiotic recombinase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP13 dual specificity phosphatase 13
DUSP4 dual specificity phosphatase 4
EPOR erythropoietin receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FDPS farnesyl diphosphate synthase
FKBP8 FK506 binding protein 8, 38kDa
FLCN folliculin
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GUSBP3 glucuronidase, beta pseudogene 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST2H2AA3 histone cluster 2, H2aa3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1L hematological and neurological expressed 1-like
HOMER3 homer scaffolding protein 3
HOXC10 homeobox C10
INSIG1 insulin induced gene 1
IQSEC2 IQ motif and Sec7 domain 2
IRF5 interferon regulatory factor 5
JUND jun D proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KIF13B kinesin family member 13B
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LOC157562 uncharacterized LOC157562
LPIN1 lipin 1
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAX MYC associated factor X
METTL5 methyltransferase like 5
MSMO1 methylsterol monooxygenase 1
MTERF4 mitochondrial transcription termination factor 4
MVK mevalonate kinase
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDE1 nudE neurodevelopment protein 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OLFML2A olfactomedin-like 2A
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLD2 phospholipase D2
PLEKHS1 pleckstrin homology domain containing, family S member 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRODH proline dehydrogenase (oxidase) 1
PVT1 Pvt1 oncogene (non-protein coding)
RAD52 RAD52 homolog (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOQ ras homolog family member Q
SH3BP2 SH3-domain binding protein 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD5 SMAD family member 5
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STXBP6 syntaxin binding protein 6 (amisyn)
SUGP1 SURP and G patch domain containing 1
TBC1D2B TBC1 domain family, member 2B
TCP11L1 t-complex 11, testis-specific-like 1
TMEM259 transmembrane protein 259
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM2 tripartite motif containing 2
TUBA3C tubulin, alpha 3c
UPK3B uroplakin 3B
VAC14 Vac14 homolog (S. cerevisiae)
VASH2 vasohibin 2
VEGFA vascular endothelial growth factor A
VGF VGF nerve growth factor inducible
VPS9D1 VPS9 domain containing 1
WLS wntless Wnt ligand secretion mediator
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSF2 acyl-CoA synthetase family member 2
ALG9 ALG9, alpha-1,2-mannosyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID4A AT rich interactive domain 4A (RBP1-like)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD2B ATPase family, AAA domain containing 2B
AUP1 ancient ubiquitous protein 1
AXIN1 axin 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRD9 bromodomain containing 9
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF80 chromosome 11 open reading frame 80
C1ORF115 chromosome 1 open reading frame 115
C2ORF44 chromosome 2 open reading frame 44
CAPN15 calpain 15
CCDC186 coiled-coil domain containing 186
CCNO cyclin O
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC7 cell division cycle 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COPS7B COP9 signalosome subunit 7B
CRNKL1 crooked neck pre-mRNA splicing factor 1
CRY2 cryptochrome circadian clock 2
CTNNBIP1 catenin, beta interacting protein 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND4B DENN/MADD domain containing 4B
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EIF5A2 eukaryotic translation initiation factor 5A2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EVPL envoplakin
FANCC Fanconi anemia, complementation group C
FANCF Fanconi anemia, complementation group F
FBXL6 F-box and leucine-rich repeat protein 6
FBXO22 F-box protein 22
FOXJ2 forkhead box J2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GMIP GEM interacting protein
GTF2I general transcription factor IIi
HELZ helicase with zinc finger
HSPA2 heat shock 70kDa protein 2
INCENP inner centromere protein antigens 135/155kDa
ITPKB inositol-trisphosphate 3-kinase B
KLC2 kinesin light chain 2
KLHL12 kelch-like family member 12
KLHL26 kelch-like family member 26
LOC100287590 uncharacterized LOC100287590
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC730101 uncharacterized LOC730101
LRP3 low density lipoprotein receptor-related protein 3
LRRC61 leucine rich repeat containing 61
METTL8 methyltransferase like 8
MGA MGA, MAX dimerization protein
MRPL17 mitochondrial ribosomal protein L17
MRPL46 mitochondrial ribosomal protein L46
MYO19 myosin XIX
NAP1L2 nucleosome assembly protein 1-like 2
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
PC pyruvate carboxylase
PECR peroxisomal trans-2-enoyl-CoA reductase
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PTDSS2 phosphatidylserine synthase 2
PTPRU protein tyrosine phosphatase, receptor type, U
RABL6 RAB, member RAS oncogene family-like 6
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAP1GAP2 RAP1 GTPase activating protein 2
RPAP2 RNA polymerase II associated protein 2
RPUSD2 RNA pseudouridylate synthase domain containing 2
SALL2 spalt-like transcription factor 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC22A18 solute carrier family 22, member 18
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
STK16 serine/threonine kinase 16
SUN2 Sad1 and UNC84 domain containing 2
TACC3 transforming, acidic coiled-coil containing protein 3
TBCCD1 TBCC domain containing 1
TCTN1 tectonic family member 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM183A transmembrane protein 183A
TMEM222 transmembrane protein 222
TNNT1 troponin T type 1 (skeletal, slow)
TRIM5 tripartite motif containing 5
TUBA3D tubulin, alpha 3d
UBQLN4 ubiquilin 4
ZC3H3 zinc finger CCCH-type containing 3
ZNF205 zinc finger protein 205
ZNF239 zinc finger protein 239
ZSCAN26 zinc finger and SCAN domain containing 26