fluphenazine-490 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the fluphenazine-490 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADD2 adducin 2 (beta)
ADH6 alcohol dehydrogenase 6 (class V)
AIM2 absent in melanoma 2
ANK2 ankyrin 2, neuronal
ARHGAP35 Rho GTPase activating protein 35
ATG12 autophagy related 12
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATXN2 ataxin 2
C1QTNF1 C1q and tumor necrosis factor related protein 1
CARD14 caspase recruitment domain family, member 14
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD28 CD28 molecule
CD300C CD300c molecule
CD44 CD44 molecule (Indian blood group)
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CFAP70 cilia and flagella associated protein 70
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCN5 chloride channel, voltage-sensitive 5
COL1A2 collagen, type I, alpha 2
CREM cAMP responsive element modulator
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPEP1 dipeptidase 1 (renal)
DSC2 desmocollin 2
DSCAM Down syndrome cell adhesion molecule
EFNB3 ephrin-B3
ELAVL4 ELAV like neuron-specific RNA binding protein 4
FRS3 fibroblast growth factor receptor substrate 3
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GDF3 growth differentiation factor 3
GLRX glutaredoxin (thioltransferase)
GPR173 G protein-coupled receptor 173
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAP1 huntingtin-associated protein 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMX1 H6 family homeobox 1
IDI2-AS1 IDI2 antisense RNA 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL12RB1 interleukin 12 receptor, beta 1
INSIG1 insulin induced gene 1
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF6 Kruppel-like factor 6
KLHL25 kelch-like family member 25
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
NELL2 NEL-like 2 (chicken)
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NNAT neuronatin
NPPA natriuretic peptide A
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OBSL1 obscurin-like 1
PDZD7 PDZ domain containing 7
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
PSG6 pregnancy specific beta-1-glycoprotein 6
PTPRT protein tyrosine phosphatase, receptor type, T
RBL2 retinoblastoma-like 2
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RHOQ ras homolog family member Q
RPS2 ribosomal protein S2
RUNDC3A RUN domain containing 3A
SALL2 spalt-like transcription factor 2
SCARA3 scavenger receptor class A, member 3
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SEZ6L seizure related 6 homolog (mouse)-like
SGK2 serum/glucocorticoid regulated kinase 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SOD2 superoxide dismutase 2, mitochondrial
SPN sialophorin
STAB1 stabilin 1
STARD5 StAR-related lipid transfer (START) domain containing 5
STX2 syntaxin 2
SUSD4 sushi domain containing 4
TCF3 transcription factor 3
THBS3 thrombospondin 3
TNNT3 troponin T type 3 (skeletal, fast)
TNS2 tensin 2
TPT1 tumor protein, translationally-controlled 1
TSPAN32 tetraspanin 32
TTR transthyretin
UBE4B ubiquitination factor E4B
UNC93B1 unc-93 homolog B1 (C. elegans)
USP2 ubiquitin specific peptidase 2
WDR48 WD repeat domain 48
WIPF1 WAS/WASL interacting protein family, member 1
WISP1 WNT1 inducible signaling pathway protein 1
ZFR zinc finger RNA binding protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AKTIP AKT interacting protein
ALX3 ALX homeobox 3
AMDHD2 amidohydrolase domain containing 2
AMPD1 adenosine monophosphate deaminase 1
APOLD1 apolipoprotein L domain containing 1
ARRB2 arrestin, beta 2
AXIN1 axin 1
BCL7B B-cell CLL/lymphoma 7B
BMS1 BMS1 ribosome biogenesis factor
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C16ORF59 chromosome 16 open reading frame 59
CA11 carbonic anhydrase XI
CAMTA2 calmodulin binding transcription activator 2
CD5 CD5 molecule
CENPE centromere protein E, 312kDa
CLCN2 chloride channel, voltage-sensitive 2
CORO1A coronin, actin binding protein, 1A
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DTWD1 DTW domain containing 1
DUSP22 dual specificity phosphatase 22
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EFNA1 ephrin-A1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELP3 elongator acetyltransferase complex subunit 3
ESRP2 epithelial splicing regulatory protein 2
EVPL envoplakin
EXOSC10 exosome component 10
EXOSC9 exosome component 9
FAN1 FANCD2/FANCI-associated nuclease 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALR3 galanin receptor 3
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GLTSCR1 glioma tumor suppressor candidate region gene 1
GOLM1 golgi membrane protein 1
HINFP histone H4 transcription factor
HIRIP3 HIRA interacting protein 3
HIST1H1C histone cluster 1, H1c
HOXA4 homeobox A4
HOXC4 homeobox C4
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
JMJD4 jumonji domain containing 4
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMAN2L lectin, mannose-binding 2-like
LMTK1 lemur tail kinase 1
LRP3 low density lipoprotein receptor-related protein 3
METTL8 methyltransferase like 8
MFAP2 microfibrillar-associated protein 2
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTRF1 mitochondrial translational release factor 1
NES nestin
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NXF2 nuclear RNA export factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHOX2B paired-like homeobox 2b
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G12A phospholipase A2, group XIIA
PMM1 phosphomannomutase 1
PODXL2 podocalyxin-like 2
POMT2 protein-O-mannosyltransferase 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCD protein kinase C, delta
RNF220 ring finger protein 220
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SACS sacsin molecular chaperone
SLC16A6 solute carrier family 16, member 6
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SNX6 sorting nexin 6
SOX12 SRY (sex determining region Y)-box 12
SOX21 SRY (sex determining region Y)-box 21
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAB2 stabilin 2
TKFC triokinase/FMN cyclase
TMEM176A transmembrane protein 176A
TMSB4Y thymosin beta 4, Y-linked
TTC26 tetratricopeptide repeat domain 26
TTC4 tetratricopeptide repeat domain 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC13B unc-13 homolog B (C. elegans)
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
WDR13 WD repeat domain 13
ZFP30 ZFP30 zinc finger protein
ZFP36 ZFP36 ring finger protein
ZIC1 Zic family member 1
ZNF286A zinc finger protein 286A
ZNF580 zinc finger protein 580
ZNF84 zinc finger protein 84
ZNHIT2 zinc finger, HIT-type containing 2
ZNRF4 zinc and ring finger 4