fluphenazine-6954 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fluphenazine-6954 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADGRE5 adhesion G protein-coupled receptor E5
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C16ORF45 chromosome 16 open reading frame 45
CCKAR cholecystokinin A receptor
CCNG2 cyclin G2
CEP164 centrosomal protein 164kDa
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSF1R colony stimulating factor 1 receptor
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DGKE diacylglycerol kinase, epsilon 64kDa
DIAPH2-AS1 DIAPH2 antisense RNA 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECE1 endothelin converting enzyme 1
EGR1 early growth response 1
EHD2 EH-domain containing 2
ELSPBP1 epididymal sperm binding protein 1
EMP1 epithelial membrane protein 1
ERCC4 excision repair cross-complementation group 4
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPC3 glypican 3
GRM1 glutamate receptor, metabotropic 1
GSTA3 glutathione S-transferase alpha 3
HBS1L HBS1-like translational GTPase
IER3 immediate early response 3
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARS methionyl-tRNA synthetase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPPE1 metallophosphoesterase 1
MYO1B myosin IB
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L3 nuclear factor, erythroid 2-like 3
NUPR1 nuclear protein, transcriptional regulator, 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OLFML2A olfactomedin-like 2A
OVGP1 oviductal glycoprotein 1, 120kDa
PARP11 poly (ADP-ribose) polymerase family, member 11
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAUR plasminogen activator, urokinase receptor
PRB4 proline-rich protein BstNI subfamily 4
PTMS parathymosin
RAB11B RAB11B, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
RGS12 regulator of G-protein signaling 12
RPGR retinitis pigmentosa GTPase regulator
SBF1 SET binding factor 1
SECISBP2L SECIS binding protein 2-like
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGSM2 small G protein signaling modulator 2
SGSM3 small G protein signaling modulator 3
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A17 solute carrier family 22, member 17
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPATA1 spermatogenesis associated 1
STC1 stanniocalcin 1
STX7 syntaxin 7
TDRKH tudor and KH domain containing
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TRAK1 trafficking protein, kinesin binding 1
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WDR62 WD repeat domain 62
WIPI1 WD repeat domain, phosphoinositide interacting 1
YLPM1 YLP motif containing 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
AARSD1 alanyl-tRNA synthetase domain containing 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BBS1 Bardet-Biedl syndrome 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C16ORF59 chromosome 16 open reading frame 59
CD3EAP CD3e molecule, epsilon associated protein
CDCA4 cell division cycle associated 4
CDR2L cerebellar degeneration-related protein 2-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CISH cytokine inducible SH2-containing protein
CIT citron rho-interacting serine/threonine kinase
CLDN9 claudin 9
COQ3 coenzyme Q3 methyltransferase
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECHDC3 enoyl CoA hydratase domain containing 3
EDC3 enhancer of mRNA decapping 3
EDC4 enhancer of mRNA decapping 4
EXO1 exonuclease 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAIM Fas apoptotic inhibitory molecule
FAM50B family with sequence similarity 50, member B
FAR2 fatty acyl CoA reductase 2
FASTKD5 FAST kinase domains 5
FZD3 frizzled class receptor 3
GHR growth hormone receptor
GLCE glucuronic acid epimerase
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HCFC2 host cell factor C2
HOXC11 homeobox C11
HPSE heparanase
HSPA2 heat shock 70kDa protein 2
ICK intestinal cell (MAK-like) kinase
IPP intracisternal A particle-promoted polypeptide
KIAA0125 KIAA0125
LINS lines homolog (Drosophila)
LYRM9 LYR motif containing 9
MAP6D1 MAP6 domain containing 1
MCM10 minichromosome maintenance complex component 10
MED15 mediator complex subunit 15
MMD monocyte to macrophage differentiation-associated
MTERF1 mitochondrial transcription termination factor 1
MTERF3 mitochondrial transcription termination factor 3
NECAP1 NECAP endocytosis associated 1
NFS1 NFS1 cysteine desulfurase
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NSD1 nuclear receptor binding SET domain protein 1
NT5C 5', 3'-nucleotidase, cytosolic
OXTR oxytocin receptor
PARD6A par-6 family cell polarity regulator alpha
PDZRN3 PDZ domain containing ring finger 3
PER3 period circadian clock 3
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PP14571 uncharacterized LOC100130449
PPAN peter pan homolog (Drosophila)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRODH proline dehydrogenase (oxidase) 1
PRR15L proline rich 15-like
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
RANGRF RAN guanine nucleotide release factor
RBL1 retinoblastoma-like 1
RBM14 RNA binding motif protein 14
S100PBP S100P binding protein
SALL2 spalt-like transcription factor 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SETMAR SET domain and mariner transposase fusion gene
SF3A3 splicing factor 3a, subunit 3, 60kDa
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC38A6 solute carrier family 38, member 6
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK4 serine peptidase inhibitor, Kazal type 4
STBD1 starch binding domain 1
TBCCD1 TBCC domain containing 1
TBL3 transducin (beta)-like 3
THOP1 thimet oligopeptidase 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM183A transmembrane protein 183A
TMSB15B thymosin beta 15B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TSPAN15 tetraspanin 15
TUBA4A tubulin, alpha 4a
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP18 ubiquitin specific peptidase 18
WFS1 Wolfram syndrome 1 (wolframin)
WRN Werner syndrome, RecQ helicase-like
XYLT2 xylosyltransferase II
ZMYM3 zinc finger, MYM-type 3
ZNF180 zinc finger protein 180
ZNF253 zinc finger protein 253
ZNF430 zinc finger protein 430