flurbiprofen-6472 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the flurbiprofen-6472 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKAP8L A kinase (PRKA) anchor protein 8-like
ANXA2P3 annexin A2 pseudogene 3
AQP1 aquaporin 1 (Colton blood group)
ART1 ADP-ribosyltransferase 1
AXL AXL receptor tyrosine kinase
C17ORF53 chromosome 17 open reading frame 53
CA5B carbonic anhydrase VB, mitochondrial
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK3 cyclin-dependent kinase 3
CEMP1 cementum protein 1
CEP162 centrosomal protein 162kDa
CIDEB cell death-inducing DFFA-like effector b
CLCA2 chloride channel accessory 2
CLTA clathrin, light chain A
COL9A3 collagen, type IX, alpha 3
CPNE7 copine VII
CTH cystathionine gamma-lyase
CXORF21 chromosome X open reading frame 21
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DFNB31 deafness, autosomal recessive 31
DHODH dihydroorotate dehydrogenase (quinone)
DIO2 deiodinase, iodothyronine, type II
DKFZP434L187 uncharacterized LOC26082
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DOK3 docking protein 3
EMC3 ER membrane protein complex subunit 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERO1LB ERO1-like beta (S. cerevisiae)
FBLN1 fibulin 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FNTB farnesyltransferase, CAAX box, beta
FOSL2 FOS-like antigen 2
FPR1 formyl peptide receptor 1
G6PC2 glucose-6-phosphatase, catalytic, 2
GALC galactosylceramidase
GALR2 galanin receptor 2
GDF10 growth differentiation factor 10
GPR15 G protein-coupled receptor 15
HHAT hedgehog acyltransferase
HIST1H4F histone cluster 1, H4f
IGL immunoglobulin lambda locus
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0509 uncharacterized LOC57242
KIF25 kinesin family member 25
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LBP lipopolysaccharide binding protein
MAL mal, T-cell differentiation protein
MAP1A microtubule-associated protein 1A
MVK mevalonate kinase
MYLK myosin light chain kinase
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NEU3 sialidase 3 (membrane sialidase)
NEURL1 neuralized E3 ubiquitin protein ligase 1
NRG1 neuregulin 1
PACRG PARK2 co-regulated
PCDHGA3 protocadherin gamma subfamily A, 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PITX1 paired-like homeodomain 1
PLAT plasminogen activator, tissue
PLCE1 phospholipase C, epsilon 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POMT2 protein-O-mannosyltransferase 2
PRB1 proline-rich protein BstNI subfamily 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11B RAB11B, member RAS oncogene family
RGS14 regulator of G-protein signaling 14
RIMS2 regulating synaptic membrane exocytosis 2
RNF39 ring finger protein 39
RNF43 ring finger protein 43
RUSC2 RUN and SH3 domain containing 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC8 sialic acid binding Ig-like lectin 8
SIRT5 sirtuin 5
SLA Src-like-adaptor
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SSTR4 somatostatin receptor 4
SSX3 synovial sarcoma, X breakpoint 3
SVIL supervillin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR8 toll-like receptor 8
TMEM144 transmembrane protein 144
TPMT thiopurine S-methyltransferase
TSC2 tuberous sclerosis 2
TSC22D2 TSC22 domain family, member 2
TTC39A tetratricopeptide repeat domain 39A
WNT6 wingless-type MMTV integration site family, member 6
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX15 arachidonate 15-lipoxygenase
ARC activity-regulated cytoskeleton-associated protein
ASPN asporin
ATAD5 ATPase family, AAA domain containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
C4ORF29 chromosome 4 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CAPN15 calpain 15
CCP110 centriolar coiled coil protein 110kDa
CDH10 cadherin 10, type 2 (T2-cadherin)
CLCF1 cardiotrophin-like cytokine factor 1
CLDN17 claudin 17
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CORO2A coronin, actin binding protein, 2A
CRLF1 cytokine receptor-like factor 1
CUL9 cullin 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DNAH17 dynein, axonemal, heavy chain 17
DOK5 docking protein 5
EGFL7 EGF-like-domain, multiple 7
FAM114A2 family with sequence similarity 114, member A2
FBXO31 F-box protein 31
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GALK1 galactokinase 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H1B histone cluster 1, H1b
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXB2 homeobox B2
IL12RB1 interleukin 12 receptor, beta 1
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
KIAA0754 KIAA0754
KRT13 keratin 13, type I
LAMP3 lysosomal-associated membrane protein 3
LOC100131532 uncharacterized LOC100131532
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MED9 mediator complex subunit 9
MUC3A mucin 3A, cell surface associated
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NELL2 NEL-like 2 (chicken)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PADI1 peptidyl arginine deiminase, type I
PCSK7 proprotein convertase subtilisin/kexin type 7
PGPEP1 pyroglutamyl-peptidase I
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRDM14 PR domain containing 14
PROL1 proline rich, lacrimal 1
PRPH peripherin
PRSS16 protease, serine, 16 (thymus)
PRSS50 protease, serine, 50
PTPRU protein tyrosine phosphatase, receptor type, U
PVRL3 poliovirus receptor-related 3
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB23 RAB23, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPS17P5 ribosomal protein S17 pseudogene 5
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SFRP5 secreted frizzled-related protein 5
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SNIP1 Smad nuclear interacting protein 1
SSPN sarcospan
STON1 stonin 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TCTN1 tectonic family member 1
TESK1 testis-specific kinase 1
TMCC2 transmembrane and coiled-coil domain family 2
TOM1 target of myb1 (chicken)
UNC119 unc-119 homolog (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
VASH2 vasohibin 2
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
WLS wntless Wnt ligand secretion mediator
ZFHX3 zinc finger homeobox 3
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF442 zinc finger protein 442
ZNF623 zinc finger protein 623
ZNF768 zinc finger protein 768
ZSWIM1 zinc finger, SWIM-type containing 1