fluspirilene-5008 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the fluspirilene-5008 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTSL4 ADAMTS-like 4
ARTN artemin
ATF3 activating transcription factor 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBS9 Bardet-Biedl syndrome 9
BHLHE40 basic helix-loop-helix family, member e40
C10ORF12 chromosome 10 open reading frame 12
C3ORF18 chromosome 3 open reading frame 18
CAMK1 calcium/calmodulin-dependent protein kinase I
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN17 claudin 17
CLEC7A C-type lectin domain family 7, member A
CXCL8 chemokine (C-X-C motif) ligand 8
DCAF4 DDB1 and CUL4 associated factor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND5B DENN/MADD domain containing 5B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC3 desmocollin 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPHB6 EPH receptor B6
EXPH5 exophilin 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FLJ42627 uncharacterized LOC645644
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GEM GTP binding protein overexpressed in skeletal muscle
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HCAR3 hydroxycarboxylic acid receptor 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BJ histone cluster 1, H2bj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB3 heat shock 27kDa protein 3
HYAL1 hyaluronoglucosaminidase 1
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBA inhibin, beta A
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIZ kizuna centrosomal protein
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LEPR leptin receptor
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP13 matrix metallopeptidase 13
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRG2 neuregulin 2
OASL 2'-5'-oligoadenylate synthetase-like
PCDHB13 protocadherin beta 13
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RNASE4 ribonuclease, RNase A family, 4
RND1 Rho family GTPase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SETBP1 SET binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRY4 sprouty homolog 4 (Drosophila)
TBC1D22A TBC1 domain family, member 22A
TEX14 testis expressed 14
TIMP3 TIMP metallopeptidase inhibitor 3
TLR5 toll-like receptor 5
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
VIPR2 vasoactive intestinal peptide receptor 2
VN1R1 vomeronasal 1 receptor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XYLB xylulokinase homolog (H. influenzae)
ZNF165 zinc finger protein 165
ZNF224 zinc finger protein 224
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D2 B9 protein domain 2
BGLAP bone gamma-carboxyglutamate (gla) protein
C10ORF88 chromosome 10 open reading frame 88
C11ORF30 chromosome 11 open reading frame 30
C1ORF35 chromosome 1 open reading frame 35
C22ORF29 chromosome 22 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CDADC1 cytidine and dCMP deaminase domain containing 1
CEP97 centrosomal protein 97kDa
CHEK2 checkpoint kinase 2
CHST10 carbohydrate sulfotransferase 10
CIDEC cell death-inducing DFFA-like effector c
COCH cochlin
CUL9 cullin 9
CXADR coxsackie virus and adenovirus receptor
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DGKE diacylglycerol kinase, epsilon 64kDa
DUSP2 dual specificity phosphatase 2
DYSF dysferlin
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ENO2 enolase 2 (gamma, neuronal)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FAM53B family with sequence similarity 53, member B
FAM86C1 family with sequence similarity 86, member C1
FANCC Fanconi anemia, complementation group C
FBXL2 F-box and leucine-rich repeat protein 2
FLT4 fms-related tyrosine kinase 4
FRMD1 FERM domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNL1 guanine nucleotide binding protein-like 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFNAR1 interferon (alpha, beta and omega) receptor 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KREMEN2 kringle containing transmembrane protein 2
LIN7A lin-7 homolog A (C. elegans)
LMBR1L limb development membrane protein 1-like
LYPD1 LY6/PLAUR domain containing 1
LYRM9 LYR motif containing 9
MALL mal, T-cell differentiation protein-like
MAMLD1 mastermind-like domain containing 1
MANSC1 MANSC domain containing 1
MAP1S microtubule-associated protein 1S
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NES nestin
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
P3H1 prolyl 3-hydroxylase 1
PAIP2B poly(A) binding protein interacting protein 2B
PAQR6 progestin and adipoQ receptor family member VI
PCDHGB5 protocadherin gamma subfamily B, 5
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZRN3 PDZ domain containing ring finger 3
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLXNA3 plexin A3
POMT2 protein-O-mannosyltransferase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PYCRL pyrroline-5-carboxylate reductase-like
RAB30 RAB30, member RAS oncogene family
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RPAP1 RNA polymerase II associated protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL13P5 ribosomal protein L13 pseudogene 5
SCML2 sex comb on midleg-like 2 (Drosophila)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2D4A SH2 domain containing 4A
SIX1 SIX homeobox 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLIT2 slit homolog 2 (Drosophila)
SLN sarcolipin
SMTN smoothelin
SNTA1 syntrophin, alpha 1
SP1 Sp1 transcription factor
STK16 serine/threonine kinase 16
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TEX40 testis expressed 40
TGFBR3 transforming growth factor, beta receptor III
TICAM1 toll-like receptor adaptor molecule 1
TK1 thymidine kinase 1, soluble
TTLL12 tubulin tyrosine ligase-like family member 12
TUBA4A tubulin, alpha 4a
VGF VGF nerve growth factor inducible
WDR18 WD repeat domain 18
ZBED1 zinc finger, BED-type containing 1
ZBTB25 zinc finger and BTB domain containing 25
ZNF286A zinc finger protein 286A
ZNF34 zinc finger protein 34
ZNF862 zinc finger protein 862
ZNRD1-AS1 ZNRD1 antisense RNA 1