fluticasone-2928 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fluticasone-2928 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACSL1 acyl-CoA synthetase long-chain family member 1
ACVR1B activin A receptor, type IB
ADORA3 adenosine A3 receptor
ANGPTL4 angiopoietin-like 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKEF1 ankyrin repeat and EF-hand domain containing 1
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
BIN1 bridging integrator 1
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CECR1 cat eye syndrome chromosome region, candidate 1
CES3 carboxylesterase 3
CLCF1 cardiotrophin-like cytokine factor 1
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DUSP1 dual specificity phosphatase 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM13A family with sequence similarity 13, member A
FBXO31 F-box protein 31
FGR FGR proto-oncogene, Src family tyrosine kinase
FKBP5 FK506 binding protein 5
FLT3 fms-related tyrosine kinase 3
FPR1 formyl peptide receptor 1
GSN gelsolin
GTDC1 glycosyltransferase-like domain containing 1
GVINP1 GTPase, very large interferon inducible pseudogene 1
HMOX2 heme oxygenase 2
IDS iduronate 2-sulfatase
IL1R2 interleukin 1 receptor, type II
IL24 interleukin 24
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4B lysine (K)-specific demethylase 4B
KLF9 Kruppel-like factor 9
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIMD1 LIM domains containing 1
LTBP1 latent transforming growth factor beta binding protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MMP19 matrix metallopeptidase 19
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTAP methylthioadenosine phosphorylase
MUC1 mucin 1, cell surface associated
NAP1L2 nucleosome assembly protein 1-like 2
NCF1C neutrophil cytosolic factor 1C pseudogene
NINJ2 ninjurin 2
NPTX1 neuronal pentraxin I
NTF3 neurotrophin 3
OGFR opioid growth factor receptor
OLAH oleoyl-ACP hydrolase
OLFM1 olfactomedin 1
PDE4DIP phosphodiesterase 4D interacting protein
PER1 period circadian clock 1
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGAP3 post-GPI attachment to proteins 3
PLSCR3 phospholipid scramblase 3
PORCN porcupine homolog (Drosophila)
POU5F1B POU class 5 homeobox 1B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RCAN1 regulator of calcineurin 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOB ras homolog family member B
RHOH ras homolog family member H
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SOCS1 suppressor of cytokine signaling 1
STARD13 StAR-related lipid transfer (START) domain containing 13
THBS1 thrombospondin 1
TMOD1 tropomodulin 1
TNC tenascin C
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPST1 tyrosylprotein sulfotransferase 1
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
USP53 ubiquitin specific peptidase 53
WDR60 WD repeat domain 60
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20
ZHX3 zinc fingers and homeoboxes 3

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADA adenosine deaminase
ADAM23 ADAM metallopeptidase domain 23
ADGRA3 adhesion G protein-coupled receptor A3
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
BCL7C B-cell CLL/lymphoma 7C
CCL2 chemokine (C-C motif) ligand 2
CHKB choline kinase beta
CHST10 carbohydrate sulfotransferase 10
CLDN15 claudin 15
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
DIXDC1 DIX domain containing 1
DOLK dolichol kinase
EGR2 early growth response 2
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA4 EPH receptor A4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM188A family with sequence similarity 188, member A
FBXL15 F-box and leucine-rich repeat protein 15
FOSL1 FOS-like antigen 1
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH2 G patch domain containing 2
GPR65 G protein-coupled receptor 65
GUSBP3 glucuronidase, beta pseudogene 3
IL1B interleukin 1, beta
IMPACT impact RWD domain protein
IRF1 interferon regulatory factor 1
ITGB7 integrin, beta 7
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDM7A lysine (K)-specific demethylase 7A
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMP5 lysosomal-associated membrane protein family, member 5
LIMD2 LIM domain containing 2
LOC157562 uncharacterized LOC157562
LRP6 low density lipoprotein receptor-related protein 6
LRRK1 leucine-rich repeat kinase 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP2 matrix metallopeptidase 2
MYBPH myosin binding protein H
MYH9 myosin, heavy chain 9, non-muscle
MYL5 myosin, light chain 5, regulatory
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NFE2 nuclear factor, erythroid 2
NLRX1 NLR family member X1
NOL12 nucleolar protein 12
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARP12 poly (ADP-ribose) polymerase family, member 12
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZD7 PDZ domain containing 7
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PNOC prepronociceptin
PRR14L proline rich 14-like
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNF126P1 ring finger protein 126 pseudogene 1
RNF44 ring finger protein 44
RPL23AP7 ribosomal protein L23a pseudogene 7
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC38A6 solute carrier family 38, member 6
SLC41A3 solute carrier family 41, member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAP1 signal transducing adaptor family member 1
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TBC1D17 TBC1 domain family, member 17
TEC tec protein tyrosine kinase
TEP1 telomerase-associated protein 1
TERT telomerase reverse transcriptase
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMOD3 tropomodulin 3 (ubiquitous)
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM25 tripartite motif containing 25
TRIM36 tripartite motif containing 36
ULK1 unc-51 like autophagy activating kinase 1
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
ZBTB39 zinc finger and BTB domain containing 39
ZC3H12A zinc finger CCCH-type containing 12A
ZC4H2 zinc finger, C4H2 domain containing
ZDHHC24 zinc finger, DHHC-type containing 24