fluvastatin-6691 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fluvastatin-6691 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRG1 adhesion G protein-coupled receptor G1
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD7 ankyrin repeat domain 7
APAF1 apoptotic peptidase activating factor 1
ARHGAP26 Rho GTPase activating protein 26
ARNT aryl hydrocarbon receptor nuclear translocator
ARRB1 arrestin, beta 1
BBC3 BCL2 binding component 3
BGN biglycan
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CARF calcium responsive transcription factor
CCL13 chemokine (C-C motif) ligand 13
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
COL6A1 collagen, type VI, alpha 1
CST1 cystatin SN
CTSG cathepsin G
DEPDC5 DEP domain containing 5
DGCR8 DGCR8 microprocessor complex subunit
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DTNB dystrobrevin, beta
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ETV6 ets variant 6
EYA1 EYA transcriptional coactivator and phosphatase 1
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FOXF1 forkhead box F1
GLI2 GLI family zinc finger 2
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPATCH4 G patch domain containing 4
GRB7 growth factor receptor-bound protein 7
GRIA3 glutamate receptor, ionotropic, AMPA 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFT27 intraflagellar transport 27
IL1B interleukin 1, beta
ING4 inhibitor of growth family, member 4
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB4 integrin, beta 4
ITGB6 integrin, beta 6
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LAMP5 lysosomal-associated membrane protein family, member 5
LIPG lipase, endothelial
LOC79999 uncharacterized LOC79999
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBL2 mannose-binding lectin (protein C) 2, soluble
MED25 mediator complex subunit 25
MEF2D myocyte enhancer factor 2D
MEG3 maternally expressed 3 (non-protein coding)
MFAP3L microfibrillar-associated protein 3-like
MLANA melan-A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRC2 mannose receptor, C type 2
MTCP1 mature T-cell proliferation 1
NEFH neurofilament, heavy polypeptide
NPC1 Niemann-Pick disease, type C1
NRG1 neuregulin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGDHL oxoglutarate dehydrogenase-like
OSBPL7 oxysterol binding protein-like 7
PCDHB3 protocadherin beta 3
PGAP3 post-GPI attachment to proteins 3
PLXNB3 plexin B3
PMEL premelanosome protein
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKCA protein kinase C, alpha
PSORS1C1 psoriasis susceptibility 1 candidate 1
RARG retinoic acid receptor, gamma
RGS14 regulator of G-protein signaling 14
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SOX21 SRY (sex determining region Y)-box 21
SP110 SP110 nuclear body protein
SV2B synaptic vesicle glycoprotein 2B
TADA3 transcriptional adaptor 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
TOX thymocyte selection-associated high mobility group box
TRAF2 TNF receptor-associated factor 2
TRIM2 tripartite motif containing 2
TUBA3C tubulin, alpha 3c
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZIC3 Zic family member 3

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMOTL2 angiomotin like 2
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ASAP1-IT1 ASAP1 intronic transcript 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BEX1 brain expressed, X-linked 1
BMP15 bone morphogenetic protein 15
C11ORF30 chromosome 11 open reading frame 30
C17ORF70 chromosome 17 open reading frame 70
C19ORF54 chromosome 19 open reading frame 54
C1ORF105 chromosome 1 open reading frame 105
CCL27 chemokine (C-C motif) ligand 27
CD79A CD79a molecule, immunoglobulin-associated alpha
CENPJ centromere protein J
CHPF chondroitin polymerizing factor
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COCH cochlin
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL6 chemokine (C-X-C motif) ligand 6
CYR61 cysteine-rich, angiogenic inducer, 61
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DMTN dematin actin binding protein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM204A family with sequence similarity 204, member A
FIP1L1 factor interacting with PAPOLA and CPSF1
FJX1 four jointed box 1 (Drosophila)
FKBP10 FK506 binding protein 10, 65 kDa
FLT4 fms-related tyrosine kinase 4
GAL3ST4 galactose-3-O-sulfotransferase 4
GID4 GID complex subunit 4
GPNMB glycoprotein (transmembrane) nmb
GRTP1 growth hormone regulated TBC protein 1
GSTA3 glutathione S-transferase alpha 3
HIST1H2BJ histone cluster 1, H2bj
HIST1H3I histone cluster 1, H3i
HIST2H2AA3 histone cluster 2, H2aa3
HOXC5 homeobox C5
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HTT huntingtin
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT140 intraflagellar transport 140
IL1R1 interleukin 1 receptor, type I
INHBB inhibin, beta B
JMJD4 jumonji domain containing 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA1456 KIAA1456
KIRREL kin of IRRE like (Drosophila)
KRT9 keratin 9, type I
LINC00472 long intergenic non-protein coding RNA 472
LRRK1 leucine-rich repeat kinase 1
MAGEA6 melanoma antigen family A6
MAP3K7CL MAP3K7 C-terminal like
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MMRN2 multimerin 2
MRPL44 mitochondrial ribosomal protein L44
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
OSR2 odd-skipped related transciption factor 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCDHGB5 protocadherin gamma subfamily B, 5
PLAC8 placenta-specific 8
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRR14L proline rich 14-like
PTX3 pentraxin 3, long
RAI2 retinoic acid induced 2
RBL1 retinoblastoma-like 1
RNF126P1 ring finger protein 126 pseudogene 1
ROM1 retinal outer segment membrane protein 1
RUNX1-IT1 RUNX1 intronic transcript 1
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SCEL sciellin
SFMBT1 Scm-like with four mbt domains 1
SLITRK5 SLIT and NTRK-like family, member 5
SNHG3 small nucleolar RNA host gene 3
SUGCT succinyl-CoA:glutarate-CoA transferase
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TMEM177 transmembrane protein 177
TMEM212 transmembrane protein 212
UBTD1 ubiquitin domain containing 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF14 zinc finger protein 14
ZNF239 zinc finger protein 239
ZNF280D zinc finger protein 280D
ZNF492 zinc finger protein 492
ZNF529 zinc finger protein 529
ZNF667 zinc finger protein 667
ZNF702P zinc finger protein 702, pseudogene
ZNF770 zinc finger protein 770
ZSCAN2 zinc finger and SCAN domain containing 2