folic acid metabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. (Gene Ontology, GO_0046655)
External Link http://amigo.geneontology.org/amigo/term/GO:0046655
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Genes

12 genes participating in the folic acid metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
DHFR dihydrofolate reductase
DHFR2 dihydrofolate reductase 2
FPGS folylpolyglutamate synthase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
PM20D2 peptidase M20 domain containing 2
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC46A1 solute carrier family 46 (folate transporter), member 1
ST20-MTHFS ST20-MTHFS readthrough