fto Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description fat mass and obesity associated|This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 79068)
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Genes

44 genes co-occuring with the biological term fto in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
BDNF brain-derived neurotrophic factor
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
ESR1 estrogen receptor 1
FAIM2 Fas apoptotic inhibitory molecule 2
FAM71F1 family with sequence similarity 71, member F1
FOXA2 forkhead box A2
FTO fat mass and obesity associated
GHRL ghrelin/obestatin prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
HHEX hematopoietically expressed homeobox
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
INSIG2 insulin induced gene 2
IRX3 iroquois homeobox 3
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LEP leptin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MC4R melanocortin 4 receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTMR9 myotubularin related protein 9
NAMPT nicotinamide phosphoribosyltransferase
NEGR1 neuronal growth regulator 1
NPC1 Niemann-Pick disease, type C1
NPFFR2 neuropeptide FF receptor 2
NPY2R neuropeptide Y receptor Y2
NRXN3 neurexin 3
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRRC2A proline-rich coiled-coil 2A
PTER phosphotriesterase related
RBL2 retinoblastoma-like 2
SCG3 secretogranin III
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SH2B1 SH2B adaptor protein 1
SLC30A8 solute carrier family 30 (zinc transporter), member 8
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM18 transmembrane protein 18
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)