fulvestrant-1043 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fulvestrant-1043 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP35 Rho GTPase activating protein 35
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARL4C ADP-ribosylation factor-like 4C
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9A ATPase, class II, type 9A
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BBS4 Bardet-Biedl syndrome 4
BIK BCL2-interacting killer (apoptosis-inducing)
BMP5 bone morphogenetic protein 5
BTG2 BTG family, member 2
BTN2A2 butyrophilin, subfamily 2, member A2
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CFLAR CASP8 and FADD-like apoptosis regulator
COBLL1 cordon-bleu WH2 repeat protein-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM149B1 family with sequence similarity 149, member B1
FGD6 FYVE, RhoGEF and PH domain containing 6
GAS6 growth arrest-specific 6
GUSBP3 glucuronidase, beta pseudogene 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
INO80B INO80 complex subunit B
INSR insulin receptor
ITM2B integral membrane protein 2B
JUND jun D proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LONP2 lon peptidase 2, peroxisomal
LPIN1 lipin 1
LPPR2 lipid phosphate phosphatase-related protein type 2
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPD3 LY6/PLAUR domain containing 3
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MCL1 myeloid cell leukemia 1
METTL7A methyltransferase like 7A
MKNK2 MAP kinase interacting serine/threonine kinase 2
NBEAL2 neurobeachin-like 2
NCOA1 nuclear receptor coactivator 1
NEBL nebulette
NEK3 NIMA-related kinase 3
PDCD6 programmed cell death 6
PHKB phosphorylase kinase, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKP2 plakophilin 2
PLA2G10 phospholipase A2, group X
PNRC1 proline-rich nuclear receptor coactivator 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTPRF protein tyrosine phosphatase, receptor type, F
PTTG3P pituitary tumor-transforming 3, pseudogene
RABGAP1L RAB GTPase activating protein 1-like
RPS2 ribosomal protein S2
SASH1 SAM and SH3 domain containing 1
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SEC24A SEC24 family member A
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD6 SMAD family member 6
SNORA21 small nucleolar RNA, H/ACA box 21
SRSF8 serine/arginine-rich splicing factor 8
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUGP1 SURP and G patch domain containing 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYCP2 synaptonemal complex protein 2
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLDC1 TBC/LysM-associated domain containing 1
TMC6 transmembrane channel-like 6
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TRAF4 TNF receptor-associated factor 4
TRIM2 tripartite motif containing 2
TRIM33 tripartite motif containing 33
TTC9 tetratricopeptide repeat domain 9
TXNIP thioredoxin interacting protein
VAMP4 vesicle-associated membrane protein 4
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WSB1 WD repeat and SOCS box containing 1
WWTR1 WW domain containing transcription regulator 1
ZBTB10 zinc finger and BTB domain containing 10
ZNF24 zinc finger protein 24
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
AMPD2 adenosine monophosphate deaminase 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ASB13 ankyrin repeat and SOCS box containing 13
ATAD5 ATPase family, AAA domain containing 5
BYSL bystin-like
C1ORF109 chromosome 1 open reading frame 109
C1ORF216 chromosome 1 open reading frame 216
C4ORF19 chromosome 4 open reading frame 19
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CCNE1 cyclin E1
CCNJ cyclin J
CD3EAP CD3e molecule, epsilon associated protein
CDC37L1 cell division cycle 37-like 1
CDT1 chromatin licensing and DNA replication factor 1
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHMP7 charged multivesicular body protein 7
CINP cyclin-dependent kinase 2 interacting protein
CNPY3 canopy FGF signaling regulator 3
COA7 cytochrome c oxidase assembly factor 7 (putative)
COCH cochlin
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CPTP ceramide-1-phosphate transfer protein
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DVL1 dishevelled segment polarity protein 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGR3 early growth response 3
FAM86B1 family with sequence similarity 86, member B1
FHL2 four and a half LIM domains 2
FHOD1 formin homology 2 domain containing 1
FOXC1 forkhead box C1
FPGS folylpolyglutamate synthase
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPB8 heat shock 22kDa protein 8
HYAL2 hyaluronoglucosaminidase 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIAA0020 KIAA0020
KIFC1 kinesin family member C1
MAP6D1 MAP6 domain containing 1
MDN1 MDN1, midasin homolog (yeast)
MED22 mediator complex subunit 22
METTL16 methyltransferase like 16
METTL8 methyltransferase like 8
MICALL2 MICAL-like 2
MSL1 male-specific lethal 1 homolog (Drosophila)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCS1 neuronal calcium sensor 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMRK1 nicotinamide riboside kinase 1
NOP2 NOP2 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
PAQR4 progestin and adipoQ receptor family member IV
PDZK1 PDZ domain containing 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PTCD2 pentatricopeptide repeat domain 2
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYGB phosphorylase, glycogen; brain
RAI14 retinoic acid induced 14
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBBP8 retinoblastoma binding protein 8
RBM38 RNA binding motif protein 38
RCL1 RNA terminal phosphate cyclase-like 1
REV1 REV1, polymerase (DNA directed)
RHOBTB1 Rho-related BTB domain containing 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF44 ring finger protein 44
RPP25 ribonuclease P/MRP 25kDa subunit
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SNIP1 Smad nuclear interacting protein 1
STC2 stanniocalcin 2
TCOF1 Treacher Collins-Franceschetti syndrome 1
TET3 tet methylcytosine dioxygenase 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THOP1 thimet oligopeptidase 1
TMEM115 transmembrane protein 115
TMEM164 transmembrane protein 164
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TPBG trophoblast glycoprotein
TSKU tsukushi, small leucine rich proteoglycan
TTLL12 tubulin tyrosine ligase-like family member 12
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
YBX2 Y box binding protein 2
ZNF239 zinc finger protein 239