fulvestrant-5202 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the fulvestrant-5202 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN2 actinin, alpha 2
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
ANXA2P3 annexin A2 pseudogene 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
BTG2 BTG family, member 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CCDC181 coiled-coil domain containing 181
CCNG2 cyclin G2
CDK6 cyclin-dependent kinase 6
CEND1 cell cycle exit and neuronal differentiation 1
DAGLA diacylglycerol lipase, alpha
DGCR2 DiGeorge syndrome critical region gene 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DTX2 deltex 2, E3 ubiquitin ligase
EHBP1L1 EH domain binding protein 1-like 1
ETAA1 Ewing tumor-associated antigen 1
EXOC7 exocyst complex component 7
FAM110B family with sequence similarity 110, member B
FAM214B family with sequence similarity 214, member B
FBN2 fibrillin 2
FGL1 fibrinogen-like 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPER1 G protein-coupled estrogen receptor 1
GPR157 G protein-coupled receptor 157
GRB7 growth factor receptor-bound protein 7
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM1 glutamate receptor, metabotropic 1
HCAR3 hydroxycarboxylic acid receptor 3
HFE hemochromatosis
HLA-C major histocompatibility complex, class I, C
HYAL3 hyaluronoglucosaminidase 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R1 interleukin 1 receptor, type I
KLHL25 kelch-like family member 25
KRT38 keratin 38, type I
LAMB4 laminin, beta 4
LBP lipopolysaccharide binding protein
LIN7A lin-7 homolog A (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
MBD2 methyl-CpG binding domain protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
METTL7A methyltransferase like 7A
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MID1 midline 1
MNMIP1 manchette microtubule inner protein 1
MTMR8 myotubularin related protein 8
MX1 MX dynamin-like GTPase 1
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NLRX1 NLR family member X1
NMT1 N-myristoyltransferase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTM neurotrimin
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PDGFA platelet-derived growth factor alpha polypeptide
PHF1 PHD finger protein 1
PIDD1 p53-induced death domain protein 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLD2 phospholipase D2
PLLP plasmolipin
PMEL premelanosome protein
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSCA prostate stem cell antigen
PTHLH parathyroid hormone-like hormone
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RPA4 replication protein A4, 30kDa
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC3 syndecan 3
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERHL2 serine hydrolase-like 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNX13 sorting nexin 13
SPRR1B small proline-rich protein 1B
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STON1 stonin 1
TBC1D2 TBC1 domain family, member 2
TLE2 transducin-like enhancer of split 2
TM4SF1 transmembrane 4 L six family member 1
TRA2A transformer 2 alpha homolog (Drosophila)
TUBA3C tubulin, alpha 3c
VAMP5 vesicle-associated membrane protein 5
ZCCHC24 zinc finger, CCHC domain containing 24
ZER1 zyg-11 related, cell cycle regulator
ZNF226 zinc finger protein 226
ZNF804A zinc finger protein 804A
ZNF821 zinc finger protein 821
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACTL8 actin-like 8
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BBS7 Bardet-Biedl syndrome 7
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC121 coiled-coil domain containing 121
CCDC47 coiled-coil domain containing 47
CCND1 cyclin D1
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CHML choroideremia-like (Rab escort protein 2)
CISH cytokine inducible SH2-containing protein
CLCN5 chloride channel, voltage-sensitive 5
COMMD10 COMM domain containing 10
CTPS1 CTP synthase 1
CUEDC1 CUE domain containing 1
CXCL12 chemokine (C-X-C motif) ligand 12
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EGR3 early growth response 3
EVPL envoplakin
EXOC5 exocyst complex component 5
FAM155B family with sequence similarity 155, member B
FBRS fibrosin
FHL2 four and a half LIM domains 2
FOXC1 forkhead box C1
GJA1 gap junction protein, alpha 1, 43kDa
HDAC4 histone deacetylase 4
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
KAT2A K(lysine) acetyltransferase 2A
KDM5C lysine (K)-specific demethylase 5C
KIAA0125 KIAA0125
KIF16B kinesin family member 16B
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
KPNA4 karyopherin alpha 4 (importin alpha 3)
KREMEN2 kringle containing transmembrane protein 2
LMAN1 lectin, mannose-binding, 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MICB MHC class I polypeptide-related sequence B
MPPED2 metallophosphoesterase domain containing 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1E myosin IE
NKRF NFKB repressing factor
NMRK1 nicotinamide riboside kinase 1
NPY1R neuropeptide Y receptor Y1
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
PC pyruvate carboxylase
PCDHA6 protocadherin alpha 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZK1 PDZ domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB1 Rho-related BTB domain containing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDCCAG3 serologically defined colon cancer antigen 3
SGK1 serum/glucocorticoid regulated kinase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT6 sirtuin 6
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD7 SMAD family member 7
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPHK1 sphingosine kinase 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMPRSS3 transmembrane protease, serine 3
TSKU tsukushi, small leucine rich proteoglycan
WDR3 WD repeat domain 3
XK X-linked Kx blood group
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF227 zinc finger protein 227
ZNF770 zinc finger protein 770