fulvestrant-523 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the fulvestrant-523 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AAMDC adipogenesis associated, Mth938 domain containing
ACSL6 acyl-CoA synthetase long-chain family member 6
ADAM22 ADAM metallopeptidase domain 22
AEN apoptosis enhancing nuclease
AGMAT agmatine ureohydrolase (agmatinase)
AGTR2 angiotensin II receptor, type 2
AKIP1 A kinase (PRKA) interacting protein 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARMC4 armadillo repeat containing 4
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB2 arrestin, beta 2
ASIP agouti signaling protein
ATG12 autophagy related 12
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BIN1 bridging integrator 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
C6 complement component 6
CAMK1G calcium/calmodulin-dependent protein kinase IG
CASR calcium-sensing receptor
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD82 CD82 molecule
CFAP70 cilia and flagella associated protein 70
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLEC1A C-type lectin domain family 1, member A
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CRYAB crystallin, alpha B
CTTN cortactin
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DISC1 disrupted in schizophrenia 1
DPY19L1 dpy-19-like 1 (C. elegans)
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EML2 echinoderm microtubule associated protein like 2
EPS8L3 EPS8-like 3
EXPH5 exophilin 5
FAM107A family with sequence similarity 107, member A
FECH ferrochelatase
FOXO1 forkhead box O1
FRAS1 Fraser extracellular matrix complex subunit 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FXYD7 FXYD domain containing ion transport regulator 7
GLRA2 glycine receptor, alpha 2
GLS glutaminase
GMPPB GDP-mannose pyrophosphorylase B
GNRH2 gonadotropin-releasing hormone 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY2 H2A histone family, member Y2
HNF1B HNF1 homeobox B
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTT huntingtin
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KIFAP3 kinesin-associated protein 3
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
L1CAM L1 cell adhesion molecule
LECT1 leukocyte cell derived chemotaxin 1
LENEP lens epithelial protein
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MED18 mediator complex subunit 18
MINK1 misshapen-like kinase 1
MT1HL1 metallothionein 1H-like 1
MVK mevalonate kinase
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYT1 myelin transcription factor 1
NDRG2 NDRG family member 2
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NUP214 nucleoporin 214kDa
OLFM1 olfactomedin 1
PCOLCE procollagen C-endopeptidase enhancer
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RHOH ras homolog family member H
RPS16 ribosomal protein S16
RUNDC3A RUN domain containing 3A
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD3 SMAD family member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SP110 SP110 nuclear body protein
SSX3 synovial sarcoma, X breakpoint 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TMF1 TATA element modulatory factor 1
TSC22D3 TSC22 domain family, member 3
TUBA3C tubulin, alpha 3c
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VWA1 von Willebrand factor A domain containing 1
YIPF4 Yip1 domain family, member 4
ZNF576 zinc finger protein 576

decreased expression

Symbol Name
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADGRE5 adhesion G protein-coupled receptor E5
AIDA axin interactor, dorsalization associated
ALPK1 alpha-kinase 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL7B B-cell CLL/lymphoma 7B
BIN3 bridging integrator 3
C12ORF29 chromosome 12 open reading frame 29
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA11 carbonic anhydrase XI
CCDC176 coiled-coil domain containing 176
CHEK2 checkpoint kinase 2
CLDN15 claudin 15
COA7 cytochrome c oxidase assembly factor 7 (putative)
CTF1 cardiotrophin 1
CUL9 cullin 9
DCP1A decapping mRNA 1A
DENND1B DENN/MADD domain containing 1B
DENND4B DENN/MADD domain containing 4B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DMXL1 Dmx-like 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP2 dual specificity phosphatase 2
E4F1 E4F transcription factor 1
EDC4 enhancer of mRNA decapping 4
EFNA3 ephrin-A3
EGR3 early growth response 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPS8 epidermal growth factor receptor pathway substrate 8
EPX eosinophil peroxidase
ERCC4 excision repair cross-complementation group 4
FAM188A family with sequence similarity 188, member A
FAM192A family with sequence similarity 192, member A
FIP1L1 factor interacting with PAPOLA and CPSF1
FJX1 four jointed box 1 (Drosophila)
FSD1 fibronectin type III and SPRY domain containing 1
FYCO1 FYVE and coiled-coil domain containing 1
GAB2 GRB2-associated binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GMIP GEM interacting protein
GSTCD glutathione S-transferase, C-terminal domain containing
HIRA histone cell cycle regulator
HIRIP3 HIRA interacting protein 3
IFNA14 interferon, alpha 14
IL17RA interleukin 17 receptor A
IL7R interleukin 7 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JMJD4 jumonji domain containing 4
JOSD1 Josephin domain containing 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KLK8 kallikrein-related peptidase 8
LMTK1 lemur tail kinase 1
LONP1 lon peptidase 1, mitochondrial
LUC7L LUC7-like (S. cerevisiae)
LUZP4 leucine zipper protein 4
MALL mal, T-cell differentiation protein-like
MARC1 mitochondrial amidoxime reducing component 1
MLXIPL MLX interacting protein-like
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPY1R neuropeptide Y receptor Y1
NRGN neurogranin (protein kinase C substrate, RC3)
NUP93 nucleoporin 93kDa
PARM1 prostate androgen-regulated mucin-like protein 1
PAX9 paired box 9
PCSK7 proprotein convertase subtilisin/kexin type 7
PFAS phosphoribosylformylglycinamidine synthase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCE protein kinase C, epsilon
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RECQL4 RecQ protein-like 4
S100A2 S100 calcium binding protein A2
SLC10A3 solute carrier family 10, member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPTBN2 spectrin, beta, non-erythrocytic 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOE1 target of EGR1, member 1 (nuclear)
TP53BP1 tumor protein p53 binding protein 1
TRAF2 TNF receptor-associated factor 2
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP20 ubiquitin specific peptidase 20
USP39 ubiquitin specific peptidase 39
WDR18 WD repeat domain 18
WDR44 WD repeat domain 44
ZBED1 zinc finger, BED-type containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF668 zinc finger protein 668