fulvestrant-5235 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fulvestrant-5235 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACOT11 acyl-CoA thioesterase 11
ADAM2 ADAM metallopeptidase domain 2
ADGRG1 adhesion G protein-coupled receptor G1
AFF1 AF4/FMR2 family, member 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APC adenomatous polyposis coli
APOC1 apolipoprotein C-I
APOLD1 apolipoprotein L domain containing 1
ARMC4 armadillo repeat containing 4
ASPH aspartate beta-hydroxylase
BAX BCL2-associated X protein
BCAS1 breast carcinoma amplified sequence 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BIN1 bridging integrator 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTG2 BTG family, member 2
C4BPA complement component 4 binding protein, alpha
CCDC64 coiled-coil domain containing 64
CCNG2 cyclin G2
CD48 CD48 molecule
CD52 CD52 molecule
CLGN calmegin
CTIF CBP80/20-dependent translation initiation factor
CTNS cystinosin, lysosomal cystine transporter
DOCK10 dedicator of cytokinesis 10
EGFL7 EGF-like-domain, multiple 7
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERC2-IT1 ERC2 intronic transcript 1
EXOC7 exocyst complex component 7
FKBP10 FK506 binding protein 10, 65 kDa
FLJ22184
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPER1 G protein-coupled estrogen receptor 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HCAR3 hydroxycarboxylic acid receptor 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIFC1 kinesin family member C1
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
LPPR2 lipid phosphate phosphatase-related protein type 2
MBD2 methyl-CpG binding domain protein 2
MET MET proto-oncogene, receptor tyrosine kinase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXD4 MAX dimerization protein 4
NIPAL2 NIPA-like domain containing 2
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ONECUT1 one cut homeobox 1
PBX2 pre-B-cell leukemia homeobox 2
PCDH7 protocadherin 7
PCDHGA10 protocadherin gamma subfamily A, 10
PHC3 polyhomeotic homolog 3 (Drosophila)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCG1 phospholipase C, gamma 1
PLIN2 perilipin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTK6 protein tyrosine kinase 6
PXN paxillin
RAB6A RAB6A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG7 SMG7 nonsense mediated mRNA decay factor
SOS2 son of sevenless homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUGP1 SURP and G patch domain containing 1
TGFB2 transforming growth factor, beta 2
THAP3 THAP domain containing, apoptosis associated protein 3
TMEM53 transmembrane protein 53
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM15 tripartite motif containing 15
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN7 tetraspanin 7
TTC9 tetratricopeptide repeat domain 9
TUBA3C tubulin, alpha 3c
VAMP5 vesicle-associated membrane protein 5
WSB1 WD repeat and SOCS box containing 1
XDH xanthine dehydrogenase
ZBTB6 zinc finger and BTB domain containing 6
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ACTL8 actin-like 8
ACTN4 actinin, alpha 4
AEN apoptosis enhancing nuclease
AKAP12 A kinase (PRKA) anchor protein 12
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASB13 ankyrin repeat and SOCS box containing 13
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C10ORF2 chromosome 10 open reading frame 2
C17ORF80 chromosome 17 open reading frame 80
C1ORF109 chromosome 1 open reading frame 109
CA11 carbonic anhydrase XI
CA12 carbonic anhydrase XII
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCNT1 cyclin T1
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CENPO centromere protein O
CHST10 carbohydrate sulfotransferase 10
COA7 cytochrome c oxidase assembly factor 7 (putative)
CUEDC1 CUE domain containing 1
CXCL12 chemokine (C-X-C motif) ligand 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DVL1 dishevelled segment polarity protein 1
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
FAM186A family with sequence similarity 186, member A
FHL2 four and a half LIM domains 2
FOXC1 forkhead box C1
GAB2 GRB2-associated binding protein 2
GATA4 GATA binding protein 4
GCHFR GTP cyclohydrolase I feedback regulator
GJA1 gap junction protein, alpha 1, 43kDa
GSTM2 glutathione S-transferase mu 2 (muscle)
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
ISYNA1 inositol-3-phosphate synthase 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JRKL JRK-like
KAT2A K(lysine) acetyltransferase 2A
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLF10 Kruppel-like factor 10
KPTN kaptin (actin binding protein)
KRI1 KRI1 homolog (S. cerevisiae)
LAMB3 laminin, beta 3
LHX6 LIM homeobox 6
LRP5L low density lipoprotein receptor-related protein 5-like
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MATK megakaryocyte-associated tyrosine kinase
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL8 methyltransferase like 8
MPPED2 metallophosphoesterase domain containing 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOP2 NOP2 nucleolar protein
NPY1R neuropeptide Y receptor Y1
NRGN neurogranin (protein kinase C substrate, RC3)
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PDZK1 PDZ domain containing 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAI14 retinoic acid induced 14
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBBP8 retinoblastoma binding protein 8
RBL1 retinoblastoma-like 1
RGS19 regulator of G-protein signaling 19
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOBTB1 Rho-related BTB domain containing 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RNF123 ring finger protein 123
RPL23AP32 ribosomal protein L23a pseudogene 32
RRP1 ribosomal RNA processing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC12A9 solute carrier family 12, member 9
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
STARD13 StAR-related lipid transfer (START) domain containing 13
STC2 stanniocalcin 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBC1D17 TBC1 domain family, member 17
THRAP3 thyroid hormone receptor associated protein 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM120B transmembrane protein 120B
TMPRSS3 transmembrane protease, serine 3
TSKU tsukushi, small leucine rich proteoglycan
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB22 zinc finger and BTB domain containing 22
ZNF239 zinc finger protein 239
ZNRD1-AS1 ZNRD1 antisense RNA 1