fulvestrant-5926 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the fulvestrant-5926 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADCK2 aarF domain containing kinase 2
AGBL2 ATP/GTP binding protein-like 2
AJAP1 adherens junctions associated protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALOX5 arachidonate 5-lipoxygenase
APLP2 amyloid beta (A4) precursor-like protein 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASIC1 acid sensing (proton gated) ion channel 1
ATP10B ATPase, class V, type 10B
ATXN2L ataxin 2-like
AUTS2 autism susceptibility candidate 2
BIN1 bridging integrator 1
BMP2K BMP2 inducible kinase
BMP6 bone morphogenetic protein 6
BST2 bone marrow stromal cell antigen 2
CD82 CD82 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLGN calmegin
CREB1 cAMP responsive element binding protein 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCTN1 dynactin 1
DIO2 deiodinase, iodothyronine, type II
ELP6 elongator acetyltransferase complex subunit 6
ERAP1 endoplasmic reticulum aminopeptidase 1
ETV6 ets variant 6
FAM110B family with sequence similarity 110, member B
FBLN1 fibulin 1
FBRS fibrosin
FGFR1 fibroblast growth factor receptor 1
FOXO4 forkhead box O4
FRMD4B FERM domain containing 4B
GLRA1 glycine receptor, alpha 1
GPATCH3 G patch domain containing 3
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
HIST1H2BJ histone cluster 1, H2bj
HLA-DMA major histocompatibility complex, class II, DM alpha
HP haptoglobin
HPX hemopexin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK7 mitogen-activated protein kinase 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAX MYC associated factor X
MIER2 mesoderm induction early response 1, family member 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPL MPL proto-oncogene, thrombopoietin receptor
MST1L macrophage stimulating 1-like
MTM1 myotubularin 1
MXD4 MAX dimerization protein 4
NEB nebulin
NLGN1 neuroligin 1
NPR2 natriuretic peptide receptor 2
NPY2R neuropeptide Y receptor Y2
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDE4C phosphodiesterase 4C, cAMP-specific
PKP1 plakophilin 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEC plectin
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PURA purine-rich element binding protein A
RAB27B RAB27B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RANBP1 RAN binding protein 1
RARA retinoic acid receptor, alpha
RELN reelin
RIMS3 regulating synaptic membrane exocytosis 3
RNF43 ring finger protein 43
SAFB scaffold attachment factor B
SCN10A sodium channel, voltage gated, type X alpha subunit
SCYL2 SCY1-like 2 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRPR signal recognition particle receptor (docking protein)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TAPBP TAP binding protein (tapasin)
TARP TCR gamma alternate reading frame protein
TMEM63A transmembrane protein 63A
TMPRSS2 transmembrane protease, serine 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC2 tuberous sclerosis 2
UBQLN4 ubiquilin 4
ULBP2 UL16 binding protein 2
UPK3B uroplakin 3B
WDR25 WD repeat domain 25
WDTC1 WD and tetratricopeptide repeats 1
ZNF606 zinc finger protein 606
ZNF750 zinc finger protein 750
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATAD5 ATPase family, AAA domain containing 5
AVPR1B arginine vasopressin receptor 1B
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDON cell adhesion associated, oncogene regulated
CES3 carboxylesterase 3
CFAP69 cilia and flagella associated protein 69
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CISH cytokine inducible SH2-containing protein
CNN2 calponin 2
CNTN5 contactin 5
COL16A1 collagen, type XVI, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPA4 carboxypeptidase A4
CRYBB2P1 crystallin, beta B2 pseudogene 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL12 chemokine (C-X-C motif) ligand 12
DES desmin
DNALI1 dynein, axonemal, light intermediate chain 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EGR3 early growth response 3
F11 coagulation factor XI
FAM86C1 family with sequence similarity 86, member C1
FBXL7 F-box and leucine-rich repeat protein 7
FHL2 four and a half LIM domains 2
FLJ11710 uncharacterized protein FLJ11710
FRK fyn-related Src family tyrosine kinase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GATA4 GATA binding protein 4
GIF gastric intrinsic factor (vitamin B synthesis)
GJA8 gap junction protein, alpha 8, 50kDa
GLDC glycine dehydrogenase (decarboxylating)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HAMP hepcidin antimicrobial peptide
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HHAT hedgehog acyltransferase
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXA4 homeobox A4
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IER3 immediate early response 3
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNK10 potassium channel, two pore domain subfamily K, member 10
LHX6 LIM homeobox 6
LIMS2 LIM and senescent cell antigen-like domains 2
LINC01587 long intergenic non-protein coding RNA 1587
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L3 nuclear factor, erythroid 2-like 3
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCBP3 poly(rC) binding protein 3
PCDHB13 protocadherin beta 13
PCDHGA8 protocadherin gamma subfamily A, 8
PGR progesterone receptor
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMEL premelanosome protein
PNPLA3 patatin-like phospholipase domain containing 3
POLM polymerase (DNA directed), mu
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PSG4 pregnancy specific beta-1-glycoprotein 4
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
ROM1 retinal outer segment membrane protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A4 solute carrier family 16, member 4
SLC41A3 solute carrier family 41, member 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STC2 stanniocalcin 2
TAS2R3 taste receptor, type 2, member 3
TBC1D2 TBC1 domain family, member 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM115 transmembrane protein 115
TMEM120B transmembrane protein 120B
TMEM53 transmembrane protein 53
TSKU tsukushi, small leucine rich proteoglycan
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA4B tubulin, alpha 4b
WNT1 wingless-type MMTV integration site family, member 1
ZFHX4 zinc finger homeobox 4
ZNF358 zinc finger protein 358
ZNF551 zinc finger protein 551
ZNF747 zinc finger protein 747
ZSWIM1 zinc finger, SWIM-type containing 1