fulvestrant-5931 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fulvestrant-5931 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADRBK2 adrenergic, beta, receptor kinase 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARNT aryl hydrocarbon receptor nuclear translocator
ASB7 ankyrin repeat and SOCS box containing 7
BATF3 basic leucine zipper transcription factor, ATF-like 3
C1QTNF1 C1q and tumor necrosis factor related protein 1
CCPG1 cell cycle progression 1
CDC25C cell division cycle 25C
CDH7 cadherin 7, type 2
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDRT1 CMT1A duplicated region transcript 1
CEP164 centrosomal protein 164kDa
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CNGA1 cyclic nucleotide gated channel alpha 1
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
CRYGD crystallin, gamma D
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DLK2 delta-like 2 homolog (Drosophila)
DNAH3 dynein, axonemal, heavy chain 3
DNAL4 dynein, axonemal, light chain 4
DOCK6 dedicator of cytokinesis 6
EDNRA endothelin receptor type A
EFNB1 ephrin-B1
ELAC2 elaC ribonuclease Z 2
EN2 engrailed homeobox 2
ESR2 estrogen receptor 2 (ER beta)
F11R F11 receptor
FBN2 fibrillin 2
FLT1 fms-related tyrosine kinase 1
FRS3 fibroblast growth factor receptor substrate 3
GALK2 galactokinase 2
GPATCH4 G patch domain containing 4
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GRTP1 growth hormone regulated TBC protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H3G histone cluster 1, H3g
HOXA6 homeobox A6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IL12RB1 interleukin 12 receptor, beta 1
ITGB5 integrin, beta 5
KCTD13 potassium channel tetramerization domain containing 13
LEF1 lymphoid enhancer-binding factor 1
LPAR3 lysophosphatidic acid receptor 3
LPCAT4 lysophosphatidylcholine acyltransferase 4
LTBP4 latent transforming growth factor beta binding protein 4
MAPT microtubule-associated protein tau
MST1 macrophage stimulating 1
MUC3B mucin 3B, cell surface associated
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYL5 myosin, light chain 5, regulatory
MYO1B myosin IB
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFX1 nuclear transcription factor, X-box binding 1
NGF nerve growth factor (beta polypeptide)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARVA parvin, alpha
PCDHGB5 protocadherin gamma subfamily B, 5
PFDN4 prefoldin subunit 4
PHF1 PHD finger protein 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POTEKP POTE ankyrin domain family, member K, pseudogene
POU3F4 POU class 3 homeobox 4
PPARD peroxisome proliferator-activated receptor delta
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRU protein tyrosine phosphatase, receptor type, U
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RPAIN RPA interacting protein
S100A3 S100 calcium binding protein A3
SAP30 Sin3A-associated protein, 30kDa
SCML2 sex comb on midleg-like 2 (Drosophila)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH2D3C SH2 domain containing 3C
SLAMF7 SLAM family member 7
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMIM8 small integral membrane protein 8
SPEG SPEG complex locus
STX2 syntaxin 2
SYNGR1 synaptogyrin 1
TCF3 transcription factor 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM8B transmembrane protein 8B
TMPRSS2 transmembrane protease, serine 2
TUBB2B tubulin, beta 2B class IIb
URI1 URI1, prefoldin-like chaperone
VGLL3 vestigial-like family member 3
YY1 YY1 transcription factor
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF710 zinc finger protein 710
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADAM15 ADAM metallopeptidase domain 15
AFF4 AF4/FMR2 family, member 4
AMPH amphiphysin
ANXA10 annexin A10
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARMC6 armadillo repeat containing 6
ARMCX4 armadillo repeat containing, X-linked 4
ARPIN actin-related protein 2/3 complex inhibitor
AURKC aurora kinase C
C14ORF79 chromosome 14 open reading frame 79
C5ORF45 chromosome 5 open reading frame 45
C8A complement component 8, alpha polypeptide
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADPS2 Ca++-dependent secretion activator 2
CCDC57 coiled-coil domain containing 57
CD1C CD1c molecule
CD70 CD70 molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CES3 carboxylesterase 3
CHRDL1 chordin-like 1
CLDND1 claudin domain containing 1
CNR2 cannabinoid receptor 2 (macrophage)
CPNE7 copine VII
CYB5R2 cytochrome b5 reductase 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
DSCAM Down syndrome cell adhesion molecule
EPPK1 epiplakin 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GDE1 glycerophosphodiester phosphodiesterase 1
GLS2 glutaminase 2 (liver, mitochondrial)
GMCL1 germ cell-less, spermatogenesis associated 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA2P5 golgin A2 pseudogene 5
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRM4 glutamate receptor, metabotropic 4
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HHAT hedgehog acyltransferase
HIST1H2AL histone cluster 1, H2al
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA3 homeobox A3
HOXB2 homeobox B2
HPS6 Hermansky-Pudlak syndrome 6
HYI hydroxypyruvate isomerase (putative)
IBSP integrin-binding sialoprotein
IL11RA interleukin 11 receptor, alpha
IL33 interleukin 33
IQCC IQ motif containing C
IREB2 iron-responsive element binding protein 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT4 keratin 4, type II
LPAR4 lysophosphatidic acid receptor 4
MAGIX MAGI family member, X-linked
METTL16 methyltransferase like 16
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MIR622 microRNA 622
NBEAL2 neurobeachin-like 2
NME5 NME/NM23 family member 5
NRTN neurturin
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OCLN occludin
ONECUT2 one cut homeobox 2
OSMR oncostatin M receptor
PAQR6 progestin and adipoQ receptor family member VI
PARPBP PARP1 binding protein
PRR14L proline rich 14-like
PRR15L proline rich 15-like
PRR7 proline rich 7 (synaptic)
RARS arginyl-tRNA synthetase
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REC8 REC8 meiotic recombination protein
REM1 RAS (RAD and GEM)-like GTP-binding 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAYSD1 SAYSVFN motif domain containing 1
SETD8 SET domain containing (lysine methyltransferase) 8
SIRAL2 SIR2 antiphage like 2
SIX1 SIX homeobox 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMAD7 SMAD family member 7
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNRPN small nuclear ribonucleoprotein polypeptide N
STK4 serine/threonine kinase 4
TFDP3 transcription factor Dp family, member 3
TGM1 transglutaminase 1
TLR4 toll-like receptor 4
TXK TXK tyrosine kinase
UNC119 unc-119 homolog (C. elegans)
ZNF214 zinc finger protein 214
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675
ZNF711 zinc finger protein 711
ZNF749 zinc finger protein 749
ZNF778 zinc finger protein 778