fulvestrant-6872 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the fulvestrant-6872 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
APP amyloid beta (A4) precursor protein
ARL15 ADP-ribosylation factor-like 15
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF6B activating transcription factor 6 beta
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP11A ATPase, class VI, type 11A
AURKA aurora kinase A
BBS9 Bardet-Biedl syndrome 9
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BTBD7 BTB (POZ) domain containing 7
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C22ORF46 chromosome 22 open reading frame 46
CAMKMT calmodulin-lysine N-methyltransferase
CCPG1 cell cycle progression 1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CRY2 cryptochrome circadian clock 2
CTBS chitobiase, di-N-acetyl-
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EHD2 EH-domain containing 2
FAIM2 Fas apoptotic inhibitory molecule 2
FAM149B1 family with sequence similarity 149, member B1
FAM188A family with sequence similarity 188, member A
FBXL8 F-box and leucine-rich repeat protein 8
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FRAS1 Fraser extracellular matrix complex subunit 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUD2 glutamate dehydrogenase 2
GMPR guanosine monophosphate reductase
GPER1 G protein-coupled estrogen receptor 1
HDAC7 histone deacetylase 7
HSPA1L heat shock 70kDa protein 1-like
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFT74 intraflagellar transport 74
IL11 interleukin 11
IL1R1 interleukin 1 receptor, type I
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCC IQ motif containing C
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNK12 potassium channel, two pore domain subfamily K, member 12
LEPR leptin receptor
LIMK1 LIM domain kinase 1
LMNA lamin A/C
LYN LYN proto-oncogene, Src family tyrosine kinase
MAL mal, T-cell differentiation protein
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MRPS12 mitochondrial ribosomal protein S12
MST1 macrophage stimulating 1
MTERF4 mitochondrial transcription termination factor 4
MUC3A mucin 3A, cell surface associated
MXD4 MAX dimerization protein 4
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NKX3-2 NK3 homeobox 2
NOP16 NOP16 nucleolar protein
NRF1 nuclear respiratory factor 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLXNA3 plexin A3
PPAP2B phosphatidic acid phosphatase type 2B
PSG4 pregnancy specific beta-1-glycoprotein 4
PTCRA pre T-cell antigen receptor alpha
RABGAP1L RAB GTPase activating protein 1-like
RBM34 RNA binding motif protein 34
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPL23AP32 ribosomal protein L23a pseudogene 32
RTN2 reticulon 2
SH3BP2 SH3-domain binding protein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPON2 spondin 2, extracellular matrix protein
SSPN sarcospan
STON1 stonin 1
STX7 syntaxin 7
TCP10L t-complex 10-like
TCTN2 tectonic family member 2
TMEM63A transmembrane protein 63A
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53I11 tumor protein p53 inducible protein 11
TSC2 tuberous sclerosis 2
TSPYL2 TSPY-like 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WDTC1 WD and tetratricopeptide repeats 1
YPEL1 yippee-like 1 (Drosophila)
ZBED4 zinc finger, BED-type containing 4
ZMYM6 zinc finger, MYM-type 6
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM15 ADAM metallopeptidase domain 15
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
ARC activity-regulated cytoskeleton-associated protein
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATAD5 ATPase family, AAA domain containing 5
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAX BCL2-associated X protein
BCL9 B-cell CLL/lymphoma 9
C11ORF30 chromosome 11 open reading frame 30
C17ORF80 chromosome 17 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C8ORF44 chromosome 8 open reading frame 44
CEP72 centrosomal protein 72kDa
CIDEC cell death-inducing DFFA-like effector c
CLGN calmegin
CNR2 cannabinoid receptor 2 (macrophage)
COPZ2 coatomer protein complex, subunit zeta 2
CORT cortistatin
CUZD1 CUB and zona pellucida-like domains 1
CXCL12 chemokine (C-X-C motif) ligand 12
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DGAT1 diacylglycerol O-acyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EGR3 early growth response 3
ELP6 elongator acetyltransferase complex subunit 6
FAM86C1 family with sequence similarity 86, member C1
FJX1 four jointed box 1 (Drosophila)
FLJ11710 uncharacterized protein FLJ11710
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAMT guanidinoacetate N-methyltransferase
GATA4 GATA binding protein 4
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
INCENP inner centromere protein antigens 135/155kDa
ITGA10 integrin, alpha 10
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLHL21 kelch-like family member 21
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MED15 mediator complex subunit 15
METTL8 methyltransferase like 8
MPPED2 metallophosphoesterase domain containing 2
MUC6 mucin 6, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NRSN2 neurensin 2
ONECUT2 one cut homeobox 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PSENEN presenilin enhancer gamma secretase subunit
QPCTL glutaminyl-peptide cyclotransferase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB23 RAB23, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHOBTB1 Rho-related BTB domain containing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPAG7 sperm associated antigen 7
STC2 stanniocalcin 2
STK16 serine/threonine kinase 16
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TEX14 testis expressed 14
TMPRSS3 transmembrane protease, serine 3
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRIM21 tripartite motif containing 21
TRIM25 tripartite motif containing 25
TSKU tsukushi, small leucine rich proteoglycan
ZBTB44 zinc finger and BTB domain containing 44
ZFP69B ZFP69 zinc finger protein B
ZNF365 zinc finger protein 365
ZNF665 zinc finger protein 665
ZNF701 zinc finger protein 701