fulvestrant-6925 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the fulvestrant-6925 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHI1 Abelson helper integration site 1
AK1 adenylate kinase 1
ANKRD26 ankyrin repeat domain 26
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ASIC2 acid sensing (proton gated) ion channel 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAAT bile acid CoA:amino acid N-acyltransferase
BTG2 BTG family, member 2
C11ORF1 chromosome 11 open reading frame 1
CASZ1 castor zinc finger 1
CCNG2 cyclin G2
CD52 CD52 molecule
CEP164 centrosomal protein 164kDa
CEP290 centrosomal protein 290kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN17 claudin 17
CLMN calmin (calponin-like, transmembrane)
CTC1 CTS telomere maintenance complex component 1
CXCR4 chemokine (C-X-C motif) receptor 4
DALRD3 DALR anticodon binding domain containing 3
DCAF11 DDB1 and CUL4 associated factor 11
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPDC5 DEP domain containing 5
DFNA5 deafness, autosomal dominant 5
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTNA dystrobrevin, alpha
EMID1 EMI domain containing 1
EPAS1 endothelial PAS domain protein 1
EPOR erythropoietin receptor
FCF1 FCF1 rRNA-processing protein
FGGY FGGY carbohydrate kinase domain containing
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS7 growth arrest-specific 7
GLI3 GLI family zinc finger 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTPBP4 GTP binding protein 4
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H3I histone cluster 1, H3i
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DOA major histocompatibility complex, class II, DO alpha
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1RN interleukin 1 receptor antagonist
INPP5K inositol polyphosphate-5-phosphatase K
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF25-AS1 KIF25 antisense RNA 1
KRT33A keratin 33A, type I
LMF2 lipase maturation factor 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MFN2 mitofusin 2
MRC2 mannose receptor, C type 2
MTRF1L mitochondrial translational release factor 1-like
MYBPC3 myosin binding protein C, cardiac
PDE4DIP phosphodiesterase 4D interacting protein
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCH1 phospholipase C, eta 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAB11B RAB11B, member RAS oncogene family
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RARG retinoic acid receptor, gamma
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBFA ribosome binding factor A (putative)
RGS10 regulator of G-protein signaling 10
RGS12 regulator of G-protein signaling 12
RRAGB Ras-related GTP binding B
RTEL1 regulator of telomere elongation helicase 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIX2 SIX homeobox 2
SMG7-AS1 SMG7 antisense RNA 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRCAP Snf2-related CREBBP activator protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STIM1 stromal interaction molecule 1
SYN2 synapsin II
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TECPR2 tectonin beta-propeller repeat containing 2
TGFB2 transforming growth factor, beta 2
TLE2 transducin-like enhancer of split 2
TMCC2 transmembrane and coiled-coil domain family 2
TMEM63A transmembrane protein 63A
TRAK1 trafficking protein, kinesin binding 1
TSC22D4 TSC22 domain family, member 4
UTRN utrophin
VAMP5 vesicle-associated membrane protein 5
WSB1 WD repeat and SOCS box containing 1
WSCD1 WSC domain containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
AARSD1 alanyl-tRNA synthetase domain containing 1
AHCTF1 AT hook containing transcription factor 1
ARHGAP11A Rho GTPase activating protein 11A
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BRIX1 BRX1, biogenesis of ribosomes
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C17ORF62 chromosome 17 open reading frame 62
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHMP7 charged multivesicular body protein 7
CLDND1 claudin domain containing 1
CRY1 cryptochrome circadian clock 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAAM1 dishevelled associated activator of morphogenesis 1
DCLRE1A DNA cross-link repair 1A
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
EGR3 early growth response 3
FAM208B family with sequence similarity 208, member B
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOXC1 forkhead box C1
GCC2 GRIP and coiled-coil domain containing 2
GCHFR GTP cyclohydrolase I feedback regulator
GEMIN4 gem (nuclear organelle) associated protein 4
GJA1 gap junction protein, alpha 1, 43kDa
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRWD1 glutamate-rich WD repeat containing 1
HPS6 Hermansky-Pudlak syndrome 6
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGFBP4 insulin-like growth factor binding protein 4
INF2 inverted formin, FH2 and WH2 domain containing
JRKL JRK-like
KLF10 Kruppel-like factor 10
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAGOHB mago-nashi homolog B (Drosophila)
METTL1 methyltransferase like 1
MICB MHC class I polypeptide-related sequence B
MKS1 Meckel syndrome, type 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NT5C2 5'-nucleotidase, cytosolic II
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
PDZK1 PDZ domain containing 1
PEX26 peroxisomal biogenesis factor 26
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POMZP3 POM121 and ZP3 fusion
POTEKP POTE ankyrin domain family, member K, pseudogene
PPAN peter pan homolog (Drosophila)
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PRAF2 PRA1 domain family, member 2
PRSS23 protease, serine, 23
PTCD1 pentatricopeptide repeat domain 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PUS1 pseudouridylate synthase 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RPL23AP7 ribosomal protein L23a pseudogene 7
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC38A10 solute carrier family 38, member 10
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLMO2 slowmo homolog 2 (Drosophila)
SMAD7 SMAD family member 7
SMYD5 SMYD family member 5
SOAT1 sterol O-acyltransferase 1
SPAG1 sperm associated antigen 1
STC2 stanniocalcin 2
TASP1 taspase, threonine aspartase, 1
TGIF2 TGFB-induced factor homeobox 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TXNRD3 thioredoxin reductase 3
UBIAD1 UbiA prenyltransferase domain containing 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR43 WD repeat domain 43
WRN Werner syndrome, RecQ helicase-like
ZC3H3 zinc finger CCCH-type containing 3
ZNF239 zinc finger protein 239
ZNF253 zinc finger protein 253
ZNF587 zinc finger protein 587
ZNF692 zinc finger protein 692