fulvestrant-6955 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the fulvestrant-6955 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AK1 adenylate kinase 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARL4C ADP-ribosylation factor-like 4C
ARNT aryl hydrocarbon receptor nuclear translocator
ARPIN actin-related protein 2/3 complex inhibitor
ASPH aspartate beta-hydroxylase
ATF6B activating transcription factor 6 beta
ATN1 atrophin 1
BMP2K BMP2 inducible kinase
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
C11ORF63 chromosome 11 open reading frame 63
C1QTNF3 C1q and tumor necrosis factor related protein 3
C7ORF43 chromosome 7 open reading frame 43
CACFD1 calcium channel flower domain containing 1
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CCNG2 cyclin G2
CHD3 chromodomain helicase DNA binding protein 3
CLSTN2 calsyntenin 2
CRTC1 CREB regulated transcription coactivator 1
CSF1 colony stimulating factor 1 (macrophage)
CYLD cylindromatosis (turban tumor syndrome)
DCTN1 dynactin 1
DOK5 docking protein 5
EDN3 endothelin 3
EFNA1 ephrin-A1
EHD2 EH-domain containing 2
EML2 echinoderm microtubule associated protein like 2
EPHA3 EPH receptor A3
EPOR erythropoietin receptor
FAM63A family with sequence similarity 63, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
GALK2 galactokinase 2
GM2A GM2 ganglioside activator
GPC4 glypican 4
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXC8 homeobox C8
HPS1 Hermansky-Pudlak syndrome 1
IFT140 intraflagellar transport 140
IL1R1 interleukin 1 receptor, type I
IQSEC2 IQ motif and Sec7 domain 2
KIAA0513 KIAA0513
KLF5 Kruppel-like factor 5 (intestinal)
LINC00597 long intergenic non-protein coding RNA 597
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A2 mannosidase, alpha, class 1A, member 2
MLX MLX, MAX dimerization protein
MXD4 MAX dimerization protein 4
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NDE1 nudE neurodevelopment protein 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOL12 nucleolar protein 12
NOTCH2 notch 2
NRF1 nuclear respiratory factor 1
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OSBP2 oxysterol binding protein 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB12 protocadherin beta 12
PCDHB13 protocadherin beta 13
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM5 PDZ and LIM domain 5
PLEC plectin
PPAP2B phosphatidic acid phosphatase type 2B
PRDM2 PR domain containing 2, with ZNF domain
PROX1 prospero homeobox 1
PSEN2 presenilin 2
QKI QKI, KH domain containing, RNA binding
RAD23B RAD23 homolog B (S. cerevisiae)
RHBDD3 rhomboid domain containing 3
RPGR retinitis pigmentosa GTPase regulator
RUNX1 runt-related transcription factor 1
RUSC2 RUN and SH3 domain containing 2
SAPCD1 suppressor APC domain containing 1
SCHIP1 schwannomin interacting protein 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOCS1 suppressor of cytokine signaling 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TK2 thymidine kinase 2, mitochondrial
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM36 tripartite motif containing 36
UBE3B ubiquitin protein ligase E3B
UEVLD UEV and lactate/malate dehyrogenase domains
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTS2 urotensin 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAV1 vav 1 guanine nucleotide exchange factor
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
AHDC1 AT hook, DNA binding motif, containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASB9 ankyrin repeat and SOCS box containing 9
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C16ORF59 chromosome 16 open reading frame 59
C4ORF19 chromosome 4 open reading frame 19
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC25 coiled-coil domain containing 25
CCDC88C coiled-coil domain containing 88C
CCND1 cyclin D1
CENPJ centromere protein J
COA7 cytochrome c oxidase assembly factor 7 (putative)
CRBN cereblon
CXCL12 chemokine (C-X-C motif) ligand 12
DDA1 DET1 and DDB1 associated 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEPTOR DEP domain containing MTOR-interacting protein
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAL4 dynein, axonemal, light chain 4
DSCAM Down syndrome cell adhesion molecule
EFCAB2 EF-hand calcium binding domain 2
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM102A family with sequence similarity 102, member A
FAM160B2 family with sequence similarity 160, member B2
FAM188A family with sequence similarity 188, member A
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOXC1 forkhead box C1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR19 G protein-coupled receptor 19
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GTPBP3 GTP binding protein 3 (mitochondrial)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H2AJ histone cluster 1, H2aj
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFT88 intraflagellar transport 88
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IRAK4 interleukin-1 receptor-associated kinase 4
JADE1 jade family PHD finger 1
KIAA0125 KIAA0125
KRI1 KRI1 homolog (S. cerevisiae)
LRRC49 leucine rich repeat containing 49
LYRM9 LYR motif containing 9
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAMLD1 mastermind-like domain containing 1
MPPED2 metallophosphoesterase domain containing 2
MTRF1 mitochondrial translational release factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
ORC1 origin recognition complex, subunit 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PYCRL pyrroline-5-carboxylate reductase-like
RAB23 RAB23, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCL1 RNA terminal phosphate cyclase-like 1
RNF31 ring finger protein 31
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCYL2 SCY1-like 2 (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIAH2 siah E3 ubiquitin protein ligase 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMYD5 SMYD family member 5
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBL3 transducin (beta)-like 3
TGDS TDP-glucose 4,6-dehydratase
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM254 transmembrane protein 254
TPBG trophoblast glycoprotein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP18 ubiquitin specific peptidase 18
WDR43 WD repeat domain 43
XBP1 X-box binding protein 1
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF180 zinc finger protein 180
ZNF239 zinc finger protein 239
ZSCAN9 zinc finger and SCAN domain containing 9