fulvestrant-6965 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fulvestrant-6965 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACVR2B activin A receptor, type IIB
AGRP agouti related neuropeptide
AK1 adenylate kinase 1
ALDOB aldolase B, fructose-bisphosphate
BCAS1 breast carcinoma amplified sequence 1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BTBD7 BTB (POZ) domain containing 7
BTN2A2 butyrophilin, subfamily 2, member A2
C1ORF21 chromosome 1 open reading frame 21
C2ORF54 chromosome 2 open reading frame 54
C9ORF9 chromosome 9 open reading frame 9
CALML3 calmodulin-like 3
CCNG2 cyclin G2
CDKN2A cyclin-dependent kinase inhibitor 2A
CLMN calmin (calponin-like, transmembrane)
COL8A2 collagen, type VIII, alpha 2
COL9A3 collagen, type IX, alpha 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DOCK6 dedicator of cytokinesis 6
DRD2 dopamine receptor D2
FAM110B family with sequence similarity 110, member B
FLJ11292
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HOXC10 homeobox C10
HSPA1L heat shock 70kDa protein 1-like
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IL12RB1 interleukin 12 receptor, beta 1
IL4R interleukin 4 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA1456 KIAA1456
KLHL28 kelch-like family member 28
LONP2 lon peptidase 2, peroxisomal
LPAR4 lysophosphatidic acid receptor 4
MAP4 microtubule-associated protein 4
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MBD1 methyl-CpG binding domain protein 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MXD4 MAX dimerization protein 4
MYO9B myosin IXB
NAG18 NAG18 mRNA
NF2 neurofibromin 2 (merlin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRAP nebulin-related anchoring protein
NXPH4 neurexophilin 4
PCDH7 protocadherin 7
PDAP1 PDGFA associated protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PSD4 pleckstrin and Sec7 domain containing 4
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11B RAB11B, member RAS oncogene family
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASAL2 RAS protein activator like 2
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SIDT2 SID1 transmembrane family, member 2
SIK1 salt-inducible kinase 1
SIVA1 SIVA1, apoptosis-inducing factor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMR3A submaxillary gland androgen regulated protein 3A
SNED1 sushi, nidogen and EGF-like domains 1
SNORA21 small nucleolar RNA, H/ACA box 21
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STK11 serine/threonine kinase 11
STON1 stonin 1
STX1A syntaxin 1A (brain)
TFIP11 tuftelin interacting protein 11
TK2 thymidine kinase 2, mitochondrial
TLE2 transducin-like enhancer of split 2
TMPRSS2 transmembrane protease, serine 2
TNK1 tyrosine kinase, non-receptor, 1
TPM1 tropomyosin 1 (alpha)
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTC28 tetratricopeptide repeat domain 28
TUBA3C tubulin, alpha 3c
UBOX5 U-box domain containing 5
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VPS9D1 VPS9 domain containing 1
YTHDC1 YTH domain containing 1
ZNF287 zinc finger protein 287
ZNF571 zinc finger protein 571
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADCK3 aarF domain containing kinase 3
ADGRA3 adhesion G protein-coupled receptor A3
AEN apoptosis enhancing nuclease
AMPD2 adenosine monophosphate deaminase 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARMC6 armadillo repeat containing 6
ASB13 ankyrin repeat and SOCS box containing 13
BAK1 BCL2-antagonist/killer 1
BBS10 Bardet-Biedl syndrome 10
BCOR BCL6 corepressor
C10ORF2 chromosome 10 open reading frame 2
C12ORF29 chromosome 12 open reading frame 29
C2ORF44 chromosome 2 open reading frame 44
C9ORF91 chromosome 9 open reading frame 91
CAMTA2 calmodulin binding transcription activator 2
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CEP85 centrosomal protein 85kDa
CISH cytokine inducible SH2-containing protein
COL4A5 collagen, type IV, alpha 5
CXCL12 chemokine (C-X-C motif) ligand 12
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
EGR3 early growth response 3
FHL2 four and a half LIM domains 2
FIG4 FIG4 phosphoinositide 5-phosphatase
FJX1 four jointed box 1 (Drosophila)
FKBP10 FK506 binding protein 10, 65 kDa
GALT galactose-1-phosphate uridylyltransferase
GDAP1 ganglioside induced differentiation associated protein 1
GJA1 gap junction protein, alpha 1, 43kDa
H2AFY2 H2A histone family, member Y2
HAUS6 HAUS augmin-like complex, subunit 6
HMHA1 histocompatibility (minor) HA-1
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IPO13 importin 13
JADE1 jade family PHD finger 1
KCTD20 potassium channel tetramerization domain containing 20
KPTN kaptin (actin binding protein)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRP5 low density lipoprotein receptor-related protein 5
LZTR1 leucine-zipper-like transcription regulator 1
MEIS1 Meis homeobox 1
MFSD12 major facilitator superfamily domain containing 12
MICB MHC class I polypeptide-related sequence B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM2 neural cell adhesion molecule 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP2 NOP2 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NUBPL nucleotide binding protein-like
OPN3 opsin 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PISD phosphatidylserine decarboxylase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PUS1 pseudouridylate synthase 1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBL1 retinoblastoma-like 1
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RRP1 ribosomal RNA processing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SETMAR SET domain and mariner transposase fusion gene
SGK1 serum/glucocorticoid regulated kinase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC16A6 solute carrier family 16, member 6
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
STAG3 stromal antigen 3
STC2 stanniocalcin 2
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TGDS TDP-glucose 4,6-dehydratase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TPBG trophoblast glycoprotein
TSKU tsukushi, small leucine rich proteoglycan
VAV1 vav 1 guanine nucleotide exchange factor
XBP1 X-box binding protein 1
ZFAND3 zinc finger, AN1-type domain 3
ZNF675 zinc finger protein 675
ZNF813 zinc finger protein 813