fulvestrant-7539 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fulvestrant-7539 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHCYL2 adenosylhomocysteinase-like 2
AKAP13 A kinase (PRKA) anchor protein 13
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA10 annexin A10
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BBS7 Bardet-Biedl syndrome 7
CD68 CD68 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDV3 CDV3 homolog (mouse)
CNOT8 CCR4-NOT transcription complex, subunit 8
COL5A1 collagen, type V, alpha 1
CREB3L1 cAMP responsive element binding protein 3-like 1
DENND3 DENN/MADD domain containing 3
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DNAL4 dynein, axonemal, light chain 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL4 ELOVL fatty acid elongase 4
ELOVL5 ELOVL fatty acid elongase 5
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM155A family with sequence similarity 155, member A
FAM214B family with sequence similarity 214, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FKBP8 FK506 binding protein 8, 38kDa
FXYD3 FXYD domain containing ion transport regulator 3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCAT glycine C-acetyltransferase
GOLGA2 golgin A2
GRAMD4 GRAM domain containing 4
GRSF1 G-rich RNA sequence binding factor 1
GUF1 GUF1 GTPase homolog (S. cerevisiae)
H2AFX H2A histone family, member X
HIST1H2AJ histone cluster 1, H2aj
HOMER3 homer scaffolding protein 3
IFI6 interferon, alpha-inducible protein 6
IREB2 iron-responsive element binding protein 2
KRIT1 KRIT1, ankyrin repeat containing
LMF1 lipase maturation factor 1
LRP3 low density lipoprotein receptor-related protein 3
MAPT microtubule-associated protein tau
MED1 mediator complex subunit 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MNX1 motor neuron and pancreas homeobox 1
MYLK myosin light chain kinase
NABP1 nucleic acid binding protein 1
NPC1 Niemann-Pick disease, type C1
OSR2 odd-skipped related transciption factor 2
PBLD phenazine biosynthesis-like protein domain containing
PDGFB platelet-derived growth factor beta polypeptide
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIBF1 progesterone immunomodulatory binding factor 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCD1 phospholipase C, delta 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11B RAB11B, member RAS oncogene family
RAD51B RAD51 paralog B
RARG retinoic acid receptor, gamma
RBL2 retinoblastoma-like 2
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPS9 ribosomal protein S9
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCAPER S-phase cyclin A-associated protein in the ER
SEC24D SEC24 family member D
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
ST20 suppressor of tumorigenicity 20
STK19 serine/threonine kinase 19
TANK TRAF family member-associated NFKB activator
TBC1D30 TBC1 domain family, member 30
TPM2 tropomyosin 2 (beta)
TTF2 transcription termination factor, RNA polymerase II
TUBA3C tubulin, alpha 3c
UBOX5 U-box domain containing 5
USP19 ubiquitin specific peptidase 19
USP20 ubiquitin specific peptidase 20
USP48 ubiquitin specific peptidase 48
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZBTB3 zinc finger and BTB domain containing 3
ZNF442 zinc finger protein 442
ZNF468 zinc finger protein 468
ZNF84 zinc finger protein 84

decreased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ADAP2 ArfGAP with dual PH domains 2
AGO4 argonaute RISC catalytic component 4
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARMC6 armadillo repeat containing 6
BFSP1 beaded filament structural protein 1, filensin
BTBD18 BTB (POZ) domain containing 18
C11ORF80 chromosome 11 open reading frame 80
C1S complement component 1, s subcomponent
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CEP41 centrosomal protein 41kDa
CHRM5 cholinergic receptor, muscarinic 5
CLDN17 claudin 17
CLDN7 claudin 7
CLDN9 claudin 9
CNTLN centlein, centrosomal protein
COBL cordon-bleu WH2 repeat protein
CRYGC crystallin, gamma C
CXCL3 chemokine (C-X-C motif) ligand 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKB diacylglycerol kinase, beta 90kDa
DLK2 delta-like 2 homolog (Drosophila)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC8 excision repair cross-complementation group 8
ETV6 ets variant 6
FAM120C family with sequence similarity 120C
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FRMD8 FERM domain containing 8
GLB1L galactosidase, beta 1-like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC11 histone deacetylase 11
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HMOX1 heme oxygenase 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSF2BP heat shock transcription factor 2 binding protein
ID2B inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein (pseudogene)
IGFLR1 IGF-like family receptor 1
IL22RA1 interleukin 22 receptor, alpha 1
INO80D INO80 complex subunit D
IQSEC2 IQ motif and Sec7 domain 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
LMTK2 lemur tyrosine kinase 2
LRRC17 leucine rich repeat containing 17
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MOCS3 molybdenum cofactor synthesis 3
MOXD1 monooxygenase, DBH-like 1
MUC3A mucin 3A, cell surface associated
NME5 NME/NM23 family member 5
NRTN neurturin
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OCLM oculomedin
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PDE12 phosphodiesterase 12
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PRB3 proline-rich protein BstNI subfamily 3
PTPRU protein tyrosine phosphatase, receptor type, U
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCL1 RNA terminal phosphate cyclase-like 1
RIN1 Ras and Rab interactor 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SCN10A sodium channel, voltage gated, type X alpha subunit
SETD6 SET domain containing 6
SLC30A4 solute carrier family 30 (zinc transporter), member 4
SLC46A3 solute carrier family 46, member 3
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPIDR scaffolding protein involved in DNA repair
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAB2 stabilin 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCTN2 tectonic family member 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM59L transmembrane protein 59-like
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNNT2 troponin T type 2 (cardiac)
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN31 tetraspanin 31
UGT8 UDP glycosyltransferase 8
WDR33 WD repeat domain 33
ZNF219 zinc finger protein 219
ZNF35 zinc finger protein 35
ZNF391 zinc finger protein 391
ZNF667 zinc finger protein 667
ZNF668 zinc finger protein 668
ZNF74 zinc finger protein 74
ZNF747 zinc finger protein 747