furin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description furin (paired basic amino acid cleaving enzyme)|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5045)
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Genes

75 genes co-occuring with the biological term furin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADGRB1 adhesion G protein-coupled receptor B1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
AXL AXL receptor tyrosine kinase
BCL2 B-cell CLL/lymphoma 2
BMP10 bone morphogenetic protein 10
BMP2 bone morphogenetic protein 2
CD109 CD109 molecule
CSK c-src tyrosine kinase
CXCL10 chemokine (C-X-C motif) ligand 10
CYSLTR1 cysteinyl leukotriene receptor 1
FAM20C family with sequence similarity 20, member C
FGF23 fibroblast growth factor 23
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FURIN furin (paired basic amino acid cleaving enzyme)
GDF2 growth differentiation factor 2
GDF5 growth differentiation factor 5
GORASP2 golgi reassembly stacking protein 2, 55kDa
GSN gelsolin
HAMP hepcidin antimicrobial peptide
HFE hemochromatosis
HFE2 hemochromatosis type 2 (juvenile)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IGF1R insulin-like growth factor 1 receptor
INHA inhibin, alpha
INHBB inhibin, beta B
ITM2B integral membrane protein 2B
KDR kinase insert domain receptor
KISS1 KiSS-1 metastasis-suppressor
MAPK14 mitogen-activated protein kinase 14
MERTK MER proto-oncogene, tyrosine kinase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MSTN myostatin
MT3 metallothionein 3
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NOTCH3 notch 3
NPPC natriuretic peptide C
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PIKFYVE phosphoinositide kinase, FYVE finger containing
PPARA peroxisome proliferator-activated receptor alpha
PRDX1 peroxiredoxin 1
PRKG1 protein kinase, cGMP-dependent, type I
PROCR protein C receptor, endothelial
RAB3D RAB3D, member RAS oncogene family
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SOD3 superoxide dismutase 3, extracellular
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
TF transferrin
TFR2 transferrin receptor 2
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
VEGFC vascular endothelial growth factor C