gabapentin-2731 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the gabapentin-2731 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD8 abhydrolase domain containing 8
ARHGAP35 Rho GTPase activating protein 35
ARSA arylsulfatase A
ASB4 ankyrin repeat and SOCS box containing 4
ATP9A ATPase, class II, type 9A
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
C14ORF105 chromosome 14 open reading frame 105
C21ORF2 chromosome 21 open reading frame 2
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCDC85B coiled-coil domain containing 85B
CD177 CD177 molecule
CDH16 cadherin 16, KSP-cadherin
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLTA clathrin, light chain A
COL5A2 collagen, type V, alpha 2
COL7A1 collagen, type VII, alpha 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCAF15 DDB1 and CUL4 associated factor 15
DIO3 deiodinase, iodothyronine, type III
DOLK dolichol kinase
EPS8L3 EPS8-like 3
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FBXL7 F-box and leucine-rich repeat protein 7
FOSL2 FOS-like antigen 2
FOXC1 forkhead box C1
GABARAPL1 GABA(A) receptor-associated protein like 1
GFER growth factor, augmenter of liver regeneration
GJA8 gap junction protein, alpha 8, 50kDa
GLI3 GLI family zinc finger 3
GPR19 G protein-coupled receptor 19
GSTTP1 glutathione S-transferase theta pseudogene 1
GYG2 glycogenin 2
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIST1H2AK histone cluster 1, H2ak
HSF2BP heat shock transcription factor 2 binding protein
IGFBP6 insulin-like growth factor binding protein 6
IL3RA interleukin 3 receptor, alpha (low affinity)
KCNIP1 Kv channel interacting protein 1
KCTD17 potassium channel tetramerization domain containing 17
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
LEPR leptin receptor
LHB luteinizing hormone beta polypeptide
LRRC31 leucine rich repeat containing 31
MARC1 mitochondrial amidoxime reducing component 1
MAU2 MAU2 sister chromatid cohesion factor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPS12 mitochondrial ribosomal protein S12
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
MYH14 myosin, heavy chain 14, non-muscle
NEK11 NIMA-related kinase 11
NRF1 nuclear respiratory factor 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXN nucleoredoxin
OVOL2 ovo-like zinc finger 2
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PADI4 peptidyl arginine deiminase, type IV
PBX1 pre-B-cell leukemia homeobox 1
PRKCQ protein kinase C, theta
PTPRF protein tyrosine phosphatase, receptor type, F
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A30 solute carrier family 25, member 30
SLMO1 slowmo homolog 1 (Drosophila)
SP140 SP140 nuclear body protein
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNDIG1 synapse differentiation inducing 1
TBX5 T-box 5
TCF3 transcription factor 3
TF transferrin
TFDP3 transcription factor Dp family, member 3
TGFBR3 transforming growth factor, beta receptor III
TLX3 T-cell leukemia homeobox 3
TMPRSS6 transmembrane protease, serine 6
TRAPPC9 trafficking protein particle complex 9
TYMP thymidine phosphorylase
UBOX5 U-box domain containing 5
VPS9D1 VPS9 domain containing 1
YIPF2 Yip1 domain family, member 2
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADGRE3 adhesion G protein-coupled receptor E3
AMDHD2 amidohydrolase domain containing 2
ANKH ANKH inorganic pyrophosphate transport regulator
APOC4 apolipoprotein C-IV
ARMCX4 armadillo repeat containing, X-linked 4
BBS7 Bardet-Biedl syndrome 7
BMP15 bone morphogenetic protein 15
BTF3P12 basic transcription factor 3 pseudogene 12
C3ORF18 chromosome 3 open reading frame 18
CAMKMT calmodulin-lysine N-methyltransferase
CBR3 carbonyl reductase 3
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP45 cilia and flagella associated protein 45
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLDN7 claudin 7
CORT cortistatin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRYGC crystallin, gamma C
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DPYS dihydropyrimidinase
DTX2 deltex 2, E3 ubiquitin ligase
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM120C family with sequence similarity 120C
FAM131A family with sequence similarity 131, member A
FLT4 fms-related tyrosine kinase 4
FOXD1 forkhead box D1
GPR75 G protein-coupled receptor 75
GRIP2 glutamate receptor interacting protein 2
GRPR gastrin-releasing peptide receptor
GSTT1 glutathione S-transferase theta 1
HDAC7 histone deacetylase 7
HIST1H2AI histone cluster 1, H2ai
HIST1H3B histone cluster 1, H3b
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
ICAM5 intercellular adhesion molecule 5, telencephalin
IDI2-AS1 IDI2 antisense RNA 1
IFT81 intraflagellar transport 81
IL12RB1 interleukin 12 receptor, beta 1
IL2 interleukin 2
ITGA10 integrin, alpha 10
KLF1 Kruppel-like factor 1 (erythroid)
KLHL36 kelch-like family member 36
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC100287590 uncharacterized LOC100287590
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MEP1B meprin A, beta
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTSS1L metastasis suppressor 1-like
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYH15 myosin, heavy chain 15
NAG18 NAG18 mRNA
NNAT neuronatin
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARG poly (ADP-ribose) glycohydrolase
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PIPOX pipecolic acid oxidase
PLA2G15 phospholipase A2, group XV
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCAN3 RCAN family member 3
REM1 RAS (RAD and GEM)-like GTP-binding 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STARD5 StAR-related lipid transfer (START) domain containing 5
STX17 syntaxin 17
STX1A syntaxin 1A (brain)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUSD5 sushi domain containing 5
TAS2R10 taste receptor, type 2, member 10
TBL1Y transducin (beta)-like 1, Y-linked
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEAD3 TEA domain family member 3
TGFBR1 transforming growth factor, beta receptor 1
THRAP3 thyroid hormone receptor associated protein 3
TIMP2 TIMP metallopeptidase inhibitor 2
TMC5 transmembrane channel-like 5
TMEM184B transmembrane protein 184B
TWSG1 twisted gastrulation BMP signaling modulator 1
USP6NL USP6 N-terminal like