gabapentin-5875 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the gabapentin-5875 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADRA1D adrenoceptor alpha 1D
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANXA10 annexin A10
APC adenomatous polyposis coli
APOL2 apolipoprotein L, 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP26 Rho GTPase activating protein 26
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATG10 autophagy related 10
BAIAP3 BAI1-associated protein 3
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACTIN cactin, spliceosome C complex subunit
CEMIP cell migration inducing protein, hyaluronan binding
CEP295 centrosomal protein 295kDa
CISH cytokine inducible SH2-containing protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREBBP CREB binding protein
DBF4B DBF4 zinc finger B
DCN decorin
DDN dendrin
DMBT1 deleted in malignant brain tumors 1
DNAAF1 dynein, axonemal, assembly factor 1
ENO3 enolase 3 (beta, muscle)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHB2 EPH receptor B2
FASLG Fas ligand (TNF superfamily, member 6)
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
HPS1 Hermansky-Pudlak syndrome 1
HPS4 Hermansky-Pudlak syndrome 4
IDUA iduronidase, alpha-L-
IL11 interleukin 11
INSR insulin receptor
IQCK IQ motif containing K
IRX4 iroquois homeobox 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
LAMP1 lysosomal-associated membrane protein 1
LECT1 leukocyte cell derived chemotaxin 1
LIPE lipase, hormone-sensitive
LMF2 lipase maturation factor 2
LRMP lymphoid-restricted membrane protein
LRP6 low density lipoprotein receptor-related protein 6
LRRK1 leucine-rich repeat kinase 1
MAPK11 mitogen-activated protein kinase 11
MAU2 MAU2 sister chromatid cohesion factor
MEGF8 multiple EGF-like-domains 8
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTMR8 myotubularin related protein 8
MYF5 myogenic factor 5
MYL10 myosin, light chain 10, regulatory
NEB nebulin
NF2 neurofibromin 2 (merlin)
PASK PAS domain containing serine/threonine kinase
PBOV1 prostate and breast cancer overexpressed 1
PCDH17 protocadherin 17
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITX1 paired-like homeodomain 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB3 plexin B3
PRDM9 PR domain containing 9
PRKCA protein kinase C, alpha
PRLR prolactin receptor
PRSS8 protease, serine, 8
PSKH1 protein serine kinase H1
RAB26 RAB26, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPP25 ribonuclease P/MRP 25kDa subunit
SAA4 serum amyloid A4, constitutive
SIX3 SIX homeobox 3
SMOX spermine oxidase
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYN3 synapsin III
TACC1 transforming, acidic coiled-coil containing protein 1
TAS2R10 taste receptor, type 2, member 10
TBL2 transducin (beta)-like 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TK2 thymidine kinase 2, mitochondrial
TM2D1 TM2 domain containing 1
TTC38 tetratricopeptide repeat domain 38
UBOX5 U-box domain containing 5
USP19 ubiquitin specific peptidase 19
WNK1 WNK lysine deficient protein kinase 1
YY1 YY1 transcription factor
ZBTB20 zinc finger and BTB domain containing 20
ZNF500 zinc finger protein 500
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
AHDC1 AT hook, DNA binding motif, containing 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMIGO2 adhesion molecule with Ig-like domain 2
AMT aminomethyltransferase
ANKRD36 ankyrin repeat domain 36
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATG2B autophagy related 2B
AUH AU RNA binding protein/enoyl-CoA hydratase
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF80 chromosome 11 open reading frame 80
C16ORF62 chromosome 16 open reading frame 62
C17ORF70 chromosome 17 open reading frame 70
C1ORF159 chromosome 1 open reading frame 159
CAPN15 calpain 15
CCDC106 coiled-coil domain containing 106
CCDC94 coiled-coil domain containing 94
CCNA1 cyclin A1
CCS copper chaperone for superoxide dismutase
CDADC1 cytidine and dCMP deaminase domain containing 1
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLDN14 claudin 14
CLIP4 CAP-GLY domain containing linker protein family, member 4
COMMD10 COMM domain containing 10
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRELD1 cysteine-rich with EGF-like domains 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGKD diacylglycerol kinase, delta 130kDa
DHRS11 dehydrogenase/reductase (SDR family) member 11
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGF epidermal growth factor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERCC2 excision repair cross-complementation group 2
ESM1 endothelial cell-specific molecule 1
EXOC5 exocyst complex component 5
FAM222B family with sequence similarity 222, member B
FANCF Fanconi anemia, complementation group F
FGF13 fibroblast growth factor 13
GPATCH2 G patch domain containing 2
HDAC9 histone deacetylase 9
HLX H2.0-like homeobox
HOOK1 hook microtubule-tethering protein 1
HOXC10 homeobox C10
IFT54 intraflagellar transport 54
ILK integrin-linked kinase
IRAK4 interleukin-1 receptor-associated kinase 4
KLHL26 kelch-like family member 26
LOC730101 uncharacterized LOC730101
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGEF1 melanoma antigen family F1
MOXD1 monooxygenase, DBH-like 1
MUM1 melanoma associated antigen (mutated) 1
NAG18 NAG18 mRNA
NCS1 neuronal calcium sensor 1
NCSTN nicastrin
NDE1 nudE neurodevelopment protein 1
NRBP1 nuclear receptor binding protein 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PCCB propionyl CoA carboxylase, beta polypeptide
PECR peroxisomal trans-2-enoyl-CoA reductase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAC1 placenta-specific 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPT2 palmitoyl-protein thioesterase 2
RGCC regulator of cell cycle
RNF122 ring finger protein 122
SALL2 spalt-like transcription factor 2
SCAI suppressor of cancer cell invasion
SCAMP5 secretory carrier membrane protein 5
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3BGR SH3 domain binding glutamate-rich protein
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC12A8 solute carrier family 12, member 8
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SND1-IT1 SND1 intronic transcript 1
SOD3 superoxide dismutase 3, extracellular
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAGLN3 transgelin 3
TLN1 talin 1
TMC7 transmembrane channel-like 7
TMEM156 transmembrane protein 156
TPST2 tyrosylprotein sulfotransferase 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
ZNF571 zinc finger protein 571
ZNF668 zinc finger protein 668
ZSCAN26 zinc finger and SCAN domain containing 26