gabexate-4220 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the gabexate-4220 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALPI alkaline phosphatase, intestinal
ALPPL2 alkaline phosphatase, placental-like 2
ANGPT2 angiopoietin 2
ANKMY1 ankyrin repeat and MYND domain containing 1
ARMC9 armadillo repeat containing 9
BGN biglycan
BRD7P3 bromodomain containing 7 pseudogene 3
C20ORF195 chromosome 20 open reading frame 195
CABP1 calcium binding protein 1
CCR4 chemokine (C-C motif) receptor 4
CD72 CD72 molecule
CD96 CD96 molecule
CHRM2 cholinergic receptor, muscarinic 2
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLEC10A C-type lectin domain family 10, member A
CLIC2 chloride intracellular channel 2
CNGB3 cyclic nucleotide gated channel beta 3
CNTD2 cyclin N-terminal domain containing 2
CPN1 carboxypeptidase N, polypeptide 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRH corticotropin releasing hormone
CSF1 colony stimulating factor 1 (macrophage)
CTNS cystinosin, lysosomal cystine transporter
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDDM3B epididymal protein 3B
EMILIN1 elastin microfibril interfacer 1
EPHA3 EPH receptor A3
ERICH1 glutamate-rich 1
ESPN espin
EYA2 EYA transcriptional coactivator and phosphatase 2
FCAR Fc fragment of IgA receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FILIP1L filamin A interacting protein 1-like
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FXYD2 FXYD domain containing ion transport regulator 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GDF10 growth differentiation factor 10
GH1 growth hormone 1
GNMT glycine N-methyltransferase
GPR37L1 G protein-coupled receptor 37 like 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
H2AFX H2A histone family, member X
HDC histidine decarboxylase
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HYAL1 hyaluronoglucosaminidase 1
IFNA2 interferon, alpha 2
IGLV1-44 immunoglobulin lambda variable 1-44
IL5RA interleukin 5 receptor, alpha
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KLF9 Kruppel-like factor 9
KLHL35 kelch-like family member 35
LOC145678 uncharacterized LOC145678
LOC284244 uncharacterized LOC284244
LST1 leukocyte specific transcript 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCPH1 microcephalin 1
MSLN mesothelin
NAGLU N-acetylglucosaminidase, alpha
NGF nerve growth factor (beta polypeptide)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPPC natriuretic peptide C
NRG2 neuregulin 2
NUDC nudC nuclear distribution protein
OR51E2 olfactory receptor, family 51, subfamily E, member 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAX8 paired box 8
PMFBP1 polyamine modulated factor 1 binding protein 1
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRG protein tyrosine phosphatase, receptor type, G
PTTG2 pituitary tumor-transforming 2
PYY peptide YY
RAB36 RAB36, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RBMY2FP RNA binding motif protein, Y-linked, family 2, member F pseudogene
RIC3 RIC3 acetylcholine receptor chaperone
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMD4B sterile alpha motif domain containing 4B
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMG7-AS1 SMG7 antisense RNA 1
SPAG11A sperm associated antigen 11A
SRPX2 sushi-repeat containing protein, X-linked 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAPT1 transmembrane anterior posterior transformation 1
TRAPPC9 trafficking protein particle complex 9
TRAT1 T cell receptor associated transmembrane adaptor 1
TRO trophinin
TSNAXIP1 translin-associated factor X interacting protein 1
UBASH3A ubiquitin associated and SH3 domain containing A
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
ZNF135 zinc finger protein 135

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADAM23 ADAM metallopeptidase domain 23
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGMAT agmatine ureohydrolase (agmatinase)
ALS2CL ALS2 C-terminal like
AMDHD2 amidohydrolase domain containing 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGAP10 Rho GTPase activating protein 10
ARL14 ADP-ribosylation factor-like 14
ATAD5 ATPase family, AAA domain containing 5
BAG4 BCL2-associated athanogene 4
BEND5 BEN domain containing 5
C22ORF29 chromosome 22 open reading frame 29
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
CCS copper chaperone for superoxide dismutase
CDK3 cyclin-dependent kinase 3
CFAP69 cilia and flagella associated protein 69
CLDN11 claudin 11
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTNAP3B contactin associated protein-like 3B
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DLK2 delta-like 2 homolog (Drosophila)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EBF2 early B-cell factor 2
EXOC6B exocyst complex component 6B
FANCE Fanconi anemia, complementation group E
FAT4 FAT atypical cadherin 4
FCF1 FCF1 rRNA-processing protein
FLT4 fms-related tyrosine kinase 4
GLDC glycine dehydrogenase (decarboxylating)
GMEB1 glucocorticoid modulatory element binding protein 1
GMPR guanosine monophosphate reductase
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H4E histone cluster 1, H4e
HOXA6 homeobox A6
IL17RA interleukin 17 receptor A
INCENP inner centromere protein antigens 135/155kDa
IPO8 importin 8
KIAA1462 KIAA1462
KLF3 Kruppel-like factor 3 (basic)
KPTN kaptin (actin binding protein)
LMTK1 lemur tail kinase 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGC12488
MOB3B MOB kinase activator 3B
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPS18C mitochondrial ribosomal protein S18C
MYLIP myosin regulatory light chain interacting protein
NDP Norrie disease (pseudoglioma)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NLGN1 neuroligin 1
NOL12 nucleolar protein 12
NSUN6 NOP2/Sun domain family, member 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PARD6A par-6 family cell polarity regulator alpha
PCDHGB5 protocadherin gamma subfamily B, 5
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE12 phosphodiesterase 12
PDE8B phosphodiesterase 8B
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLBD1 phospholipase B domain containing 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRB3 proline-rich protein BstNI subfamily 3
RIN1 Ras and Rab interactor 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SALL2 spalt-like transcription factor 2
SAYSD1 SAYSVFN motif domain containing 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35F6 solute carrier family 35, member F6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYTL2 synaptotagmin-like 2
TAGLN3 transgelin 3
TGFBI transforming growth factor, beta-induced, 68kDa
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TRIM66 tripartite motif containing 66
TWISTNB TWIST neighbor
TXLNG taxilin gamma
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC13B unc-13 homolog B (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
YY2 YY2 transcription factor
ZNF137P zinc finger protein 137, pseudogene
ZNF227 zinc finger protein 227
ZNF239 zinc finger protein 239
ZNF391 zinc finger protein 391
ZNF711 zinc finger protein 711
ZNF767P zinc finger family member 767, pseudogene