gabexate-7357 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the gabexate-7357 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP1 ArfGAP with dual PH domains 1
AMBP alpha-1-microglobulin/bikunin precursor
ANP32A-IT1 ANP32A intronic transcript 1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF7IP activating transcription factor 7 interacting protein
ATXN2L ataxin 2-like
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CADM4 cell adhesion molecule 4
CASS4 Cas scaffolding protein family member 4
CDC25C cell division cycle 25C
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYR61 cysteine-rich, angiogenic inducer, 61
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPYSL4 dihydropyrimidinase-like 4
DUSP2 dual specificity phosphatase 2
DVL2 dishevelled segment polarity protein 2
EDN2 endothelin 2
EDNRB endothelin receptor type B
EGFL7 EGF-like-domain, multiple 7
ETV7 ets variant 7
FAM13C family with sequence similarity 13, member C
FAM169A family with sequence similarity 169, member A
FAM65A family with sequence similarity 65, member A
FBXO2 F-box protein 2
FGF2 fibroblast growth factor 2 (basic)
FGFR4 fibroblast growth factor receptor 4
FLJ22184
GNAS GNAS complex locus
GRK5 G protein-coupled receptor kinase 5
GRM8 glutamate receptor, metabotropic 8
HIST1H2AL histone cluster 1, H2al
HOMER3 homer scaffolding protein 3
HPS1 Hermansky-Pudlak syndrome 1
HYAL4 hyaluronoglucosaminidase 4
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ING4 inhibitor of growth family, member 4
ITPK1 inositol-tetrakisphosphate 1-kinase
KIF25 kinesin family member 25
KMT2A lysine (K)-specific methyltransferase 2A
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LGALS2 lectin, galactoside-binding, soluble, 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHX6 LIM homeobox 6
LRP2 low density lipoprotein receptor-related protein 2
LRP5L low density lipoprotein receptor-related protein 5-like
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCF2L MCF.2 cell line derived transforming sequence-like
MED16 mediator complex subunit 16
MINK1 misshapen-like kinase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRX1 NLR family member X1
OASL 2'-5'-oligoadenylate synthetase-like
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PARVB parvin, beta
PDE11A phosphodiesterase 11A
PITX2 paired-like homeodomain 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLIN2 perilipin 2
POFUT1 protein O-fucosyltransferase 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRF1 perforin 1 (pore forming protein)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RBP4 retinol binding protein 4, plasma
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RLN1 relaxin 1
RNF208 ring finger protein 208
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPTBN1 spectrin, beta, non-erythrocytic 1
STIM1 stromal interaction molecule 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR8 toll-like receptor 8
TMPRSS2 transmembrane protease, serine 2
TNK1 tyrosine kinase, non-receptor, 1
TRBC1 T cell receptor beta constant 1
TRIB2 tribbles pseudokinase 2
TSPY1 testis specific protein, Y-linked 1
VPRBP Vpr (HIV-1) binding protein
WDFY3 WD repeat and FYVE domain containing 3
XK X-linked Kx blood group
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF710 zinc finger protein 710
ZNF783 zinc finger family member 783
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAP2 ArfGAP with dual PH domains 2
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
AFF4 AF4/FMR2 family, member 4
ANKZF1 ankyrin repeat and zinc finger domain containing 1
BAG4 BCL2-associated athanogene 4
CDKN2AIP CDKN2A interacting protein
CDON cell adhesion associated, oncogene regulated
CENPT centromere protein T
CHML choroideremia-like (Rab escort protein 2)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYBG3 beta-gamma crystallin domain containing 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DMC1 DNA meiotic recombinase 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ETAA1 Ewing tumor-associated antigen 1
FAM160B2 family with sequence similarity 160, member B2
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11710 uncharacterized protein FLJ11710
GDAP1 ganglioside induced differentiation associated protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL1 guanine nucleotide binding protein-like 1
GPATCH2L G patch domain containing 2-like
GPC3 glypican 3
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H2BC histone cluster 1, H2bc
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HOXC13 homeobox C13
HP1BP3 heterochromatin protein 1, binding protein 3
IFI6 interferon, alpha-inducible protein 6
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INSIG2 insulin induced gene 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIF13B kinesin family member 13B
KLF3 Kruppel-like factor 3 (basic)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIG4 ligase IV, DNA, ATP-dependent
LYPD1 LY6/PLAUR domain containing 1
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MCOLN3 mucolipin 3
MFSD11 major facilitator superfamily domain containing 11
MIS18BP1 MIS18 binding protein 1
MOSPD3 motile sperm domain containing 3
NDRG4 NDRG family member 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L3 nuclear factor, erythroid 2-like 3
NIPAL2 NIPA-like domain containing 2
NLK nemo-like kinase
NRSN2 neurensin 2
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP16 poly (ADP-ribose) polymerase family, member 16
PARPBP PARP1 binding protein
PCDHA9 protocadherin alpha 9
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PODXL2 podocalyxin-like 2
RAB23 RAB23, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RNF25 ring finger protein 25
RPGR retinitis pigmentosa GTPase regulator
SCYL2 SCY1-like 2 (S. cerevisiae)
SDC3 syndecan 3
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC46A3 solute carrier family 46, member 3
SP1 Sp1 transcription factor
SPIDR scaffolding protein involved in DNA repair
SSFA2 sperm specific antigen 2
SYTL2 synaptotagmin-like 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D17 TBC1 domain family, member 17
THBS3 thrombospondin 3
TMEM2 transmembrane protein 2
TOLLIP toll interacting protein
TPST1 tyrosylprotein sulfotransferase 1
UPP1 uridine phosphorylase 1
WDR76 WD repeat domain 76
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227
ZNF280D zinc finger protein 280D
ZNF35 zinc finger protein 35
ZNF573 zinc finger protein 573
ZNF586 zinc finger protein 586
ZNF767P zinc finger family member 767, pseudogene