gadd45a Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description growth arrest and DNA-damage-inducible, alpha|This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 1647)
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Genes

33 genes co-occuring with the biological term gadd45a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AURKA aurora kinase A
BTG2 BTG family, member 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCNB1 cyclin B1
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ESR2 estrogen receptor 2 (ER beta)
FLT1 fms-related tyrosine kinase 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HMGB1 high mobility group box 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
MAPK8 mitogen-activated protein kinase 8
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NAMPT nicotinamide phosphoribosyltransferase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PER2 period circadian clock 2
RB1 retinoblastoma 1
RUNX1 runt-related transcription factor 1
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TARID TCF21 antisense RNA inducing promoter demethylation
TDG thymine-DNA glycosylase
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TXN thioredoxin