| Dataset | GO Cellular Component Annotations 2015 |
| Category | structural or functional annotations |
| Type | cellular component |
| Description | A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0070765 |
| Similar Terms | |
| Downloads & Tools |
3 proteins localized to the gamma-secretase complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.
