ganglioneuroblastoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.|A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, and nodular.|A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea (MeSH).|A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular. (Experimental Factor Ontology, EFO_0000502)
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Genes

61 genes co-occuring with the disease ganglioneuroblastoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.87929
VIP vasoactive intestinal peptide 1.6525
ENO2 enolase 2 (gamma, neuronal) 1.32541
NTS neurotensin 1.2909
NUMBL numb homolog (Drosophila)-like 1.21695
DOCK6 dedicator of cytokinesis 6 1.1312
GNS glucosamine (N-acetyl)-6-sulfatase 1.12783
GALP galanin-like peptide 1.12066
SYP synaptophysin 0.923387
PRLH prolactin releasing hormone 0.852811
PHOX2B paired-like homeobox 2b 0.824948
SST somatostatin 0.736649
NOTO notochord homeobox 0.688692
CHGA chromogranin A 0.674315
SKI SKI proto-oncogene 0.667152
WASF3 WAS protein family, member 3 0.621792
ENO3 enolase 3 (beta, muscle) 0.615529
FABP7 fatty acid binding protein 7, brain 0.597961
NPY neuropeptide Y 0.576161
ENO1 enolase 1, (alpha) 0.563335
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.536183
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.499997
HLA-DOB major histocompatibility complex, class II, DO beta 0.465416
POMC proopiomelanocortin 0.460129
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.454847
KDM1A lysine (K)-specific demethylase 1A 0.446935
CTH cystathionine gamma-lyase 0.443923
PRIMA1 proline rich membrane anchor 1 0.421016
ALK anaplastic lymphoma receptor tyrosine kinase 0.391141
TH tyrosine hydroxylase 0.385936
NMT1 N-myristoyltransferase 1 0.382223
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.364085
DAP death-associated protein 0.349349
FGF8 fibroblast growth factor 8 (androgen-induced) 0.34384
FTL ferritin, light polypeptide 0.342739
FTH1 ferritin, heavy polypeptide 1 0.342739
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.320454
UTS2 urotensin 2 0.309928
NF1 neurofibromin 1 0.307757
CD82 CD82 molecule 0.307395
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.295492
NGF nerve growth factor (beta polypeptide) 0.291898
CXCR5 chemokine (C-X-C motif) receptor 5 0.266203
CD177 CD177 molecule 0.264077
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.251718
KRT20 keratin 20, type I 0.23945
RBP3 retinol binding protein 3, interstitial 0.232836
HTRA1 HtrA serine peptidase 1 0.231448
PCNA proliferating cell nuclear antigen 0.211597
HCRT hypocretin (orexin) neuropeptide precursor 0.211597
CD58 CD58 molecule 0.207912
CXCL13 chemokine (C-X-C motif) ligand 13 0.19742
MAEA macrophage erythroblast attacher 0.184128
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.173701
PDLIM7 PDZ and LIM domain 7 (enigma) 0.173571
EDNRB endothelin receptor type B 0.171036
MGMT O-6-methylguanine-DNA methyltransferase 0.170789
CD9 CD9 molecule 0.162908
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.159658
BDNF brain-derived neurotrophic factor 0.158605
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.157357