gap junction Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. (Gene Ontology, GO_0005921)
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Genes

185 proteins co-occuring with the gap junction cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GJA1 gap junction protein, alpha 1, 43kDa 5.21117
GJC1 gap junction protein, gamma 1, 45kDa 3.06909
GJD2 gap junction protein, delta 2, 36kDa 3.06172
GJB2 gap junction protein, beta 2, 26kDa 3.05025
GJB1 gap junction protein, beta 1, 32kDa 3.04302
GJA5 gap junction protein, alpha 5, 40kDa 2.78173
GJA4 gap junction protein, alpha 4, 37kDa 2.67354
GJB6 gap junction protein, beta 6, 30kDa 2.31052
PANX1 pannexin 1 2.09765
GJA3 gap junction protein, alpha 3, 46kDa 1.97203
GJB3 gap junction protein, beta 3, 31kDa 1.80106
GJA8 gap junction protein, alpha 8, 50kDa 1.80039
PANX2 pannexin 2 1.76755
GJC2 gap junction protein, gamma 2, 47kDa 1.67933
PANX3 pannexin 3 1.54178
GJB5 gap junction protein, beta 5, 31.1kDa 1.48645
GJC3 gap junction protein, gamma 3, 30.2kDa 1.46495
MIP major intrinsic protein of lens fiber 1.36692
GJB4 gap junction protein, beta 4, 30.3kDa 1.35375
TJP1 tight junction protein 1 1.22308
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.1245
GJD3 gap junction protein, delta 3, 31.9kDa 1.10715
PKP2 plakophilin 2 0.914376
FBXO2 F-box protein 2 0.868126
C6ORF62 chromosome 6 open reading frame 62 0.837351
C15ORF32 chromosome 15 open reading frame 32 0.837351
C7ORF60 chromosome 7 open reading frame 60 0.837351
SCN5A sodium channel, voltage gated, type V alpha subunit 0.796062
GJA9 gap junction protein, alpha 9, 59kDa 0.788275
OCLN occludin 0.783241
PVALB parvalbumin 0.736014
DSP desmoplakin 0.728389
GJB7 gap junction protein, beta 7, 25kDa 0.713682
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.712351
JUP junction plakoglobin 0.692078
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.674196
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.623504
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 0.61968
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.605706
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.574244
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.573828
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.573828
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.543176
RNF182 ring finger protein 182 0.535772
FGF2 fibroblast growth factor 2 (basic) 0.520206
CRYGA crystallin, gamma A 0.519798
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.519389
PRKCA protein kinase C, alpha 0.501881
TEAD4 TEA domain family member 4 0.486904
GUCY2C guanylate cyclase 2C 0.468001
INS insulin 0.466399
OTOR otoraplin 0.464397
SOX17 SRY (sex determining region Y)-box 17 0.463598
NOS3 nitric oxide synthase 3 (endothelial cell) 0.461199
NPR1 natriuretic peptide receptor 1 0.459203
KNG1 kininogen 1 0.458803
FAAH fatty acid amide hydrolase 0.457606
NPPC natriuretic peptide C 0.449245
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.425531
FGF1 fibroblast growth factor 1 (acidic) 0.424745
GCM1 glial cells missing homolog 1 (Drosophila) 0.423174
MAP2K7 mitogen-activated protein kinase kinase 7 0.422782
TJP2 tight junction protein 2 0.420036
CHRM1 cholinergic receptor, muscarinic 1 0.417685
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.412992
GJD4 gap junction protein, delta 4, 40.1kDa 0.409479
ARMCX1 armadillo repeat containing, X-linked 1 0.404415
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.400916
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.397423
TBX2 T-box 2 0.393936
HRAS Harvey rat sarcoma viral oncogene homolog 0.387751
EDNRA endothelin receptor type A 0.385436
STX8 syntaxin 8 0.385051
CTTNBP2NL CTTNBP2 N-terminal like 0.382739
TBX5 T-box 5 0.382354
SETD6 SET domain containing 6 0.381969
GLS2 glutaminase 2 (liver, mitochondrial) 0.381584
GDF5 growth differentiation factor 5 0.378122
TNF tumor necrosis factor 0.376202
OTOS otospiralin 0.364713
JUN jun proto-oncogene 0.360896
ACE angiotensin I converting enzyme 0.356324
REN renin 0.355944
MOG myelin oligodendrocyte glycoprotein 0.354422
CLDN1 claudin 1 0.353282
AREG amphiregulin 0.352901
MPZ myelin protein zero 0.352142
GFAP glial fibrillary acidic protein 0.350243
CLDN7 claudin 7 0.348725
CNR1 cannabinoid receptor 1 (brain) 0.343421
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.342285
GLS glutaminase 0.341907
LIM2 lens intrinsic membrane protein 2, 19kDa 0.339639
ALPP alkaline phosphatase, placental 0.338506
EPS8L1 EPS8-like 1 0.332095
ADCY2 adenylate cyclase 2 (brain) 0.327956
FOS FBJ murine osteosarcoma viral oncogene homolog 0.321201
TMEM59 transmembrane protein 59 0.320077
ALPPL2 alkaline phosphatase, placental-like 2 0.318953
MGAM maltase-glucoamylase 0.318953
ALPL alkaline phosphatase, liver/bone/kidney 0.318579
NEUROD1 neuronal differentiation 1 0.314465
SOST sclerostin 0.313344
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.310358
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.301054
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.295489
OXTR oxytocin receptor 0.292897
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.292157
MIR130B microRNA 130b 0.289569
EDNRB endothelin receptor type B 0.286614
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.285138
CLDN14 claudin 14 0.284769
CALCA calcitonin-related polypeptide alpha 0.280349
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.278509
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.278509
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.271533
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.269335
MAPK14 mitogen-activated protein kinase 14 0.268969
OPN4 opsin 4 0.266408
TGFB1 transforming growth factor, beta 1 0.259837
TNNT1 troponin T type 1 (skeletal, slow) 0.259473
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.258381
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 0.257652
SP8 Sp8 transcription factor 0.25547
GUCA2A guanylate cyclase activator 2A (guanylin) 0.251839
CRYBB2 crystallin, beta B2 0.251839
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.248216
DNAH8 dynein, axonemal, heavy chain 8 0.246046
IGF1 insulin-like growth factor 1 (somatomedin C) 0.246046
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.245685
POMC proopiomelanocortin 0.238119
EDN1 endothelin 1 0.236324
CAV1 caveolin 1, caveolae protein, 22kDa 0.235966
CSK c-src tyrosine kinase 0.235249
CSN2 casein beta 0.232386
CALB2 calbindin 2 0.226331
ALB albumin 0.225976
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.221025
PMP22 peripheral myelin protein 22 0.218914
BMP4 bone morphogenetic protein 4 0.21681
TH tyrosine hydroxylase 0.21228
DSC2 desmocollin 2 0.210549
IRX6 iroquois homeobox 6 0.207451
GCG glucagon 0.207451
OCM oncomodulin 0.205399
SHKBP1 SH3KBP1 binding protein 1 0.202346
NOV nephroblastoma overexpressed 0.199325
MPDZ multiple PDZ domain protein 0.196669
OCM2 oncomodulin 2 0.1921
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.190814
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 0.190175
FAT3 FAT atypical cadherin 3 0.187646
FOXC2 forkhead box C2 0.183328
PTH parathyroid hormone 0.181524
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.181227
TBX18 T-box 18 0.180339
TNNI3 troponin I type 3 (cardiac) 0.178588
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.178299
C19ORF26 chromosome 19 open reading frame 26 0.177724
FGF9 fibroblast growth factor 9 0.175745
NKX2-5 NK2 homeobox 5 0.175188
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.174911
CLMP CXADR-like membrane protein 0.174635
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.173814
NALCN sodium leak channel, non selective 0.171673
IL1B interleukin 1, beta 0.170888
PLXNB2 plexin B2 0.170114
ADRA1D adrenoceptor alpha 1D 0.169859
ASTN1 astrotactin 1 0.168598
VCL vinculin 0.168101
NPS neuropeptide S 0.167856
TCF12 transcription factor 12 0.167366
GATA4 GATA binding protein 4 0.166167
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.166167
PTCH1 patched 1 0.163865
SMOC2 SPARC related modular calcium binding 2 0.1632
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.16298
ARID4A AT rich interactive domain 4A (RBP1-like) 0.16233
DBT dihydrolipoamide branched chain transacylase E2 0.160863
NES nestin 0.160658
CYR61 cysteine-rich, angiogenic inducer, 61 0.159856
TMC6 transmembrane channel-like 6 0.159462
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.158129
MIR15B microRNA 15b 0.156863
FN1 fibronectin 1 0.156513