gapdh Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description glyceraldehyde-3-phosphate dehydrogenase|This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 2597)
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Genes

45 genes co-occuring with the biological term gapdh in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIRE autoimmune regulator
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APP amyloid beta (A4) precursor protein
CDK1 cyclin-dependent kinase 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREBBP CREB binding protein
CRYAB crystallin, alpha B
CSF1 colony stimulating factor 1 (macrophage)
CTGF connective tissue growth factor
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
EDN1 endothelin 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
ENO1 enolase 1, (alpha)
FKBP6 FK506 binding protein 6, 36kDa
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPA4 heat shock 70kDa protein 4
HTT huntingtin
MIR644A microRNA 644a
MST1 macrophage stimulating 1
MUC3A mucin 3A, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MZF1 myeloid zinc finger 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NONO non-POU domain containing, octamer-binding
PABPC1 poly(A) binding protein, cytoplasmic 1
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
RPL13A ribosomal protein L13a
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SP1 Sp1 transcription factor
SRSF1 serine/arginine-rich splicing factor 1
TERC telomerase RNA component
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TPI1 triosephosphate isomerase 1
TPPP tubulin polymerization promoting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C