gdnf Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description glial cell derived neurotrophic factor|This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 2668)
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Genes

43 genes co-occuring with the biological term gdnf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BDNF brain-derived neurotrophic factor
CLDN5 claudin 5
DPYSL2 dihydropyrimidinase-like 2
EDN3 endothelin 3
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
GAS1 growth arrest-specific 1
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
INHBA inhibin, beta A
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
NCAM1 neural cell adhesion molecule 1
NGF nerve growth factor (beta polypeptide)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRTN neurturin
NTF3 neurotrophin 3
NTF4 neurotrophin 4
PROK1 prokineticin 1
PROKR1 prokineticin receptor 1
PROKR2 prokineticin receptor 2
PSPN persephin
RET ret proto-oncogene
S100B S100 calcium binding protein B
SDC3 syndecan 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
TH tyrosine hydroxylase
TRIM28 tripartite motif containing 28
VEGFA vascular endothelial growth factor A
VGF VGF nerve growth factor inducible
ZEB2 zinc finger E-box binding homeobox 2
ZNF256 zinc finger protein 256