geldanamycin-1228 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the geldanamycin-1228 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGR2 anterior gradient 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C4 aldo-keto reductase family 1, member C4
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP35 Rho GTPase activating protein 35
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BAG3 BCL2-associated athanogene 3
CA5B carbonic anhydrase VB, mitochondrial
CACYBP calcyclin binding protein
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP164 centrosomal protein 164kDa
CFAP69 cilia and flagella associated protein 69
CHMP6 charged multivesicular body protein 6
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL7A1 collagen, type VII, alpha 1
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIDO1 death inducer-obliterator 1
DMBT1 deleted in malignant brain tumors 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
EDRF1 erythroid differentiation regulatory factor 1
EGF epidermal growth factor
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESRRG estrogen-related receptor gamma
FKBP4 FK506 binding protein 4, 59kDa
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABARAPL1 GABA(A) receptor-associated protein like 1
GGT1 gamma-glutamyltransferase 1
GPM6A glycoprotein M6A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AJ histone cluster 1, H2aj
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IL7R interleukin 7 receptor
KSR1 kinase suppressor of ras 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPDZ multiple PDZ domain protein
N4BP2L1 NEDD4 binding protein 2-like 1
NACA nascent polypeptide-associated complex alpha subunit
NAP1L2 nucleosome assembly protein 1-like 2
NCAPH2 non-SMC condensin II complex, subunit H2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NPR3 natriuretic peptide receptor 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA4 protein disulfide isomerase family A, member 4
PDZD2 PDZ domain containing 2
PENK proenkephalin
PGAP1 post-GPI attachment to proteins 1
PHF7 PHD finger protein 7
PTGES2 prostaglandin E synthase 2
PTHLH parathyroid hormone-like hormone
RETN resistin
RGS14 regulator of G-protein signaling 14
RGS4 regulator of G-protein signaling 4
RTEL1 regulator of telomere elongation helicase 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERHL2 serine hydrolase-like 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SORBS1 sorbin and SH3 domain containing 1
STIP1 stress-induced phosphoprotein 1
SZT2 seizure threshold 2 homolog (mouse)
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM50B transmembrane protein 50B
TMPRSS15 transmembrane protease, serine 15
TRABD TraB domain containing
TRIM2 tripartite motif containing 2
TUBGCP3 tubulin, gamma complex associated protein 3
WDR33 WD repeat domain 33
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF277 zinc finger protein 277
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AEN apoptosis enhancing nuclease
AHDC1 AT hook, DNA binding motif, containing 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD36B ankyrin repeat domain 36B
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARMC6 armadillo repeat containing 6
BMP4 bone morphogenetic protein 4
C10ORF88 chromosome 10 open reading frame 88
C16ORF59 chromosome 16 open reading frame 59
C1ORF105 chromosome 1 open reading frame 105
C4ORF19 chromosome 4 open reading frame 19
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CARD8 caspase recruitment domain family, member 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPT centromere protein T
CFAP44 cilia and flagella associated protein 44
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COBL cordon-bleu WH2 repeat protein
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTSF cathepsin F
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEPTOR DEP domain containing MTOR-interacting protein
DPY19L2P2 DPY19L2 pseudogene 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EFNA3 ephrin-A3
ELP6 elongator acetyltransferase complex subunit 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ESRP2 epithelial splicing regulatory protein 2
EXO1 exonuclease 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM102A family with sequence similarity 102, member A
FAM53C family with sequence similarity 53, member C
FANCE Fanconi anemia, complementation group E
FHOD1 formin homology 2 domain containing 1
GBX2 gastrulation brain homeobox 2
GMEB1 glucocorticoid modulatory element binding protein 1
GPR19 G protein-coupled receptor 19
GRAMD3 GRAM domain containing 3
HOXC13 homeobox C13
HPS6 Hermansky-Pudlak syndrome 6
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IER2 immediate early response 2
IL17RA interleukin 17 receptor A
IL32 interleukin 32
ISYNA1 inositol-3-phosphate synthase 1
JUNB jun B proto-oncogene
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KDM3A lysine (K)-specific demethylase 3A
KIZ kizuna centrosomal protein
LMBR1L limb development membrane protein 1-like
MFSD12 major facilitator superfamily domain containing 12
MMP9 matrix metallopeptidase 9
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTERF4 mitochondrial transcription termination factor 4
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NOL12 nucleolar protein 12
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRTN neurturin
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAQR6 progestin and adipoQ receptor family member VI
PCSK7 proprotein convertase subtilisin/kexin type 7
PELP1 proline, glutamate and leucine rich protein 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PRKCD protein kinase C, delta
PRR14L proline rich 14-like
PRR15L proline rich 15-like
PSKH1 protein serine kinase H1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RGS20 regulator of G-protein signaling 20
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD1B SET domain containing 1B
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPATA2L spermatogenesis associated 2-like
SPEG SPEG complex locus
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TERF2 telomeric repeat binding factor 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM40 transmembrane protein 40
TNRC6B trinucleotide repeat containing 6B
TRNAU1AP tRNA selenocysteine 1 associated protein 1
USP18 ubiquitin specific peptidase 18
USP27X ubiquitin specific peptidase 27, X-linked
VEGFA vascular endothelial growth factor A
ZNF143 zinc finger protein 143
ZNF282 zinc finger protein 282
ZNF324 zinc finger protein 324