geldanamycin-1653 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the geldanamycin-1653 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADCY7 adenylate cyclase 7
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARG2 arginase 2
ARHGAP35 Rho GTPase activating protein 35
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATF2 activating transcription factor 2
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BAG2 BCL2-associated athanogene 2
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CACYBP calcyclin binding protein
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD58 CD58 molecule
CENPC centromere protein C
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHRM3 cholinergic receptor, muscarinic 3
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DDIT4 DNA-damage-inducible transcript 4
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
FAM46C family with sequence similarity 46, member C
FGFR2 fibroblast growth factor receptor 2
GLRX glutaredoxin (thioltransferase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOMER3 homer scaffolding protein 3
HOXA5 homeobox A5
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IRS2 insulin receptor substrate 2
LINC00094 long intergenic non-protein coding RNA 94
LPIN1 lipin 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
METTL16 methyltransferase like 16
MFN2 mitofusin 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
N4BP2L2 NEDD4 binding protein 2-like 2
NAP1L2 nucleosome assembly protein 1-like 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSBPL1A oxysterol binding protein-like 1A
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA4 protein disulfide isomerase family A, member 4
PDLIM7 PDZ and LIM domain 7 (enigma)
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PMP22 peripheral myelin protein 22
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRKCI protein kinase C, iota
PROS1 protein S (alpha)
PSG9 pregnancy specific beta-1-glycoprotein 9
RFPL2 ret finger protein-like 2
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRC2 arginine/serine-rich coiled-coil 2
SAFB2 scaffold attachment factor B2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SIK1 salt-inducible kinase 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAP23 synaptosomal-associated protein, 23kDa
SOX9 SRY (sex determining region Y)-box 9
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STARD13 StAR-related lipid transfer (START) domain containing 13
STIP1 stress-induced phosphoprotein 1
STYK1 serine/threonine/tyrosine kinase 1
TES testin LIM domain protein
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TSC22D4 TSC22 domain family, member 4
TUBGCP3 tubulin, gamma complex associated protein 3
ULBP2 UL16 binding protein 2
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNRD1-AS1 ZNRD1 antisense RNA 1

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
AMPD2 adenosine monophosphate deaminase 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD3A ATPase family, AAA domain containing 3A
BIK BCL2-interacting killer (apoptosis-inducing)
BRPF1 bromodomain and PHD finger containing, 1
CAMTA1 calmodulin binding transcription activator 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBX4 chromobox homolog 4
CCDC15 coiled-coil domain containing 15
CCNE2 cyclin E2
CD3EAP CD3e molecule, epsilon associated protein
CDT1 chromatin licensing and DNA replication factor 1
CLASRP CLK4-associating serine/arginine rich protein
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COA7 cytochrome c oxidase assembly factor 7 (putative)
CORO2A coronin, actin binding protein, 2A
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTPS1 CTP synthase 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGR3 early growth response 3
ERCC8 excision repair cross-complementation group 8
FAM102A family with sequence similarity 102, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GUSBP3 glucuronidase, beta pseudogene 3
HOXC11 homeobox C11
HOXC13 homeobox C13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
INHBB inhibin, beta B
IPO13 importin 13
IRAK4 interleukin-1 receptor-associated kinase 4
ITPKB inositol-trisphosphate 3-kinase B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF10 Kruppel-like factor 10
LAS1L LAS1-like (S. cerevisiae)
LIAS lipoic acid synthetase
LOC642236 FSHD region gene 1 pseudogene
MAST3 microtubule associated serine/threonine kinase 3
METTL2B methyltransferase like 2B
MITF microphthalmia-associated transcription factor
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIP7 NIP7, nucleolar pre-rRNA processing protein
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NXT1 nuclear transport factor 2-like export factor 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PARD6A par-6 family cell polarity regulator alpha
PCF11 PCF11 cleavage and polyadenylation factor subunit
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKCD protein kinase C, delta
PTPRU protein tyrosine phosphatase, receptor type, U
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM14 RNA binding motif protein 14
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS16 regulator of G-protein signaling 16
RIBC2 RIB43A domain with coiled-coils 2
RIPK4 receptor-interacting serine-threonine kinase 4
SCO2 SCO2 cytochrome c oxidase assembly protein
SETD8 SET domain containing (lysine methyltransferase) 8
SETMAR SET domain and mariner transposase fusion gene
SH2B2 SH2B adaptor protein 2
SIDT1 SID1 transmembrane family, member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SPATA2L spermatogenesis associated 2-like
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
SYTL2 synaptotagmin-like 2
TEAD3 TEA domain family member 3
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPCN1 two pore segment channel 1
TRAPPC12 trafficking protein particle complex 12
TTC4 tetratricopeptide repeat domain 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBQLN4 ubiquilin 4
ZNF232 zinc finger protein 232
ZNF239 zinc finger protein 239
ZNF282 zinc finger protein 282
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652
ZNF787 zinc finger protein 787
ZXDC ZXD family zinc finger C